Astroglia Abnormalities in Post-stroke Mood Disorders

Singer, Tracey; Ding, Sarah; Ding, Shinghua

doi:10.1007/978-3-030-77375-5_6

Cited by 8 publications

(11 citation statements)

References 150 publications

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“… 7 ), and proliferating astrocytes are a likely origin for this. Also epilepsy or mood disorders following stroke or TBI have been linked to astroglia abnormalities 41 , 43 , as disease progression in Alzheimer’s disease 6 or chronic pain 42 . Indeed, proliferating astrocytes have specific molecular properties, as highlighted in previous preclinical mouse models 9 , 12 , 21 and here by GAL3 expression.…”

Section: Discussionmentioning

confidence: 99%

Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain

Sirko,

Schichor,

Della Vecchia

et al. 2023

Nat Med

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The glial environment influences neurological disease progression, yet much of our knowledge still relies on preclinical animal studies, especially regarding astrocyte heterogeneity. In murine models of traumatic brain injury, beneficial functions of proliferating reactive astrocytes on disease outcome have been unraveled, but little is known regarding if and when they are present in human brain pathology. Here we examined a broad spectrum of pathologies with and without intracerebral hemorrhage and found a striking correlation between lesions involving blood–brain barrier rupture and astrocyte proliferation that was further corroborated in an assay probing for neural stem cell potential. Most importantly, proteomic analysis unraveled a crucial signaling pathway regulating this astrocyte plasticity with GALECTIN3 as a novel marker for proliferating astrocytes and the GALECTIN3-binding protein LGALS3BP as a functional hub mediating astrocyte proliferation and neurosphere formation. Taken together, this work identifies a therapeutically relevant astrocyte response and their molecular regulators in different pathologies affecting the human cerebral cortex.

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Section: Discussionmentioning

confidence: 99%

Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain

Sirko,

Schichor,

Della Vecchia

et al. 2023

Nat Med

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“…Decreases in serotonin levels from baseline to after rehabilitation have been correlated with worsening in cognitive functions, as indicated by changes in the Rey's figure, and the Tower of London test [69]. The altered inflammatory response by astrocytes has also been proposed to explain depression and cognitive impairment after stroke [70]. It is also possible that disruption of connections in the cognitive and limbic systems [71] caused by the vascular accident could explain the relationship between post-stroke depression and cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Post-Stroke Depressive Symptoms on Cognitive Performance in Women and in Men: A 4 Month Prospective Study

Sobreiro

Terroni

Mattos

et al. 2023

Life

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Background: Depressive symptoms have been associated with cognitive impairment after stroke, and women may be specifically affected. Objective: The aim of this study was to investigate gender-specific characteristics in the relationship between changes in depression severity and changes in cognitive performance after stroke. Methods: We prospectively evaluated 73 patients without a previous history of depression in the first and fourth months after a first ischemic stroke. The severity of depressive symptoms was assessed using the 31-item version of the Hamilton Rating Scale for Depression, and executive function, attention, working memory, and verbal fluency were assessed using a neuropsychological battery. Results: We included 46 (63.0%) men and 27 (36.9%) women, with mean ages of 55.2 (SD ± 15.1) and 46.8 (SD ± 14.7) years, respectively. We found significant improvement in the digit span forward and Stroop dots from month 1 to month 4 post stroke for both men and women. Women, but not men, presented a correlation between changes in phonemic verbal fluency and changes in the 31-item version of the Hamilton Rating Scale for Depression scores. Improvement in depression was correlated with improvement in verbal fluency, and worsening in depression was correlated with worsening in verbal fluency. Conclusions: Our results suggest that women might be more vulnerable to the relationship between depressive symptoms and cognitive performance, and improvement of depression may be necessary for women’s improvement in phonemic verbal fluency from the first to the fourth month after a stroke. We did not adjust the results for multiple comparisons. Thus, our findings might be considered preliminary, and confirmatory studies, also focusing on specific characteristics of women that could explain these differences, are warranted.

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“…In major depressive disorder, a disease where substantial data from human post-mortem brain tissue illustrates involvement of astroglia in both disease onset and severity as well as in treatment-assisted recovery [158][159][160], astroglial atrophy has been observed without classic indications of reactivity [161,162]. Reductions in astroglial size and/or number have been noted in cortical and limbic regions in patients with mood disorders [163]. Likewise downregulation of classic astroglial functional markers have been noted in animal models of major depressive disorder, including aquaporins, connexins, glutamate transporters and glutamine synthetase [163].…”

Section: Astrocyte Heterogeneity In Disease Statesmentioning

confidence: 99%

“…Reductions in astroglial size and/or number have been noted in cortical and limbic regions in patients with mood disorders [163]. Likewise downregulation of classic astroglial functional markers have been noted in animal models of major depressive disorder, including aquaporins, connexins, glutamate transporters and glutamine synthetase [163]. Following traumatic brain injury, reductions in GAT-3 expression coincident with onset of reactive astrogliosis, disrupt cognitive function, supporting the notion that astrocyte activation interrupts functional astrocyte heterogeneity by conversion to a reactive state [118].…”

Section: Astrocyte Heterogeneity In Disease Statesmentioning

confidence: 99%

Astrocyte Heterogeneity in Regulation of Synaptic Activity

Kruyer

2022

Cells

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Our awareness of the number of synapse regulatory functions performed by astroglia is rapidly expanding, raising interesting questions regarding astrocyte heterogeneity and specialization across brain regions. Whether all astrocytes are poised to signal in a multitude of ways, or are instead tuned to surrounding synapses and how astroglial signaling is altered in psychiatric and cognitive disorders are fundamental questions for the field. In recent years, molecular and morphological characterization of astroglial types has broadened our ability to design studies to better analyze and manipulate specific functions of astroglia. Recent data emerging from these studies will be discussed in depth in this review. I also highlight remaining questions emerging from new techniques recently applied toward understanding the roles of astrocytes in synapse regulation in the adult brain.

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Astroglia Abnormalities in Post-stroke Mood Disorders

Cited by 8 publications

References 150 publications

Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain

Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain

The Impact of Post-Stroke Depressive Symptoms on Cognitive Performance in Women and in Men: A 4 Month Prospective Study

Astrocyte Heterogeneity in Regulation of Synaptic Activity

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