Astrogorgiadiol and astrogorgin, inhibitors of cell division in fertilized starfish eggs, from a gorgonian astrogorgia sp.

A new 9,11-secosterol with a 1,4-quinone from a Korean marine sponge Ircinia sp.

“…Likewise, 13,14-secosteroids have been isolated from terrestrial plants (Bhandari et al 2006;Kirson et al 1976;Qiu et al 2008) and some of which have been demonstrated to possess anti-inflammatory activities (Qiu et al 2008). 9,11-Secosterols, the third group of secosteroids, are very rare in terrestrial organisms, and are instead of found primarily in marine invertebrates, mainly corals (Huang et al 2012;Cheng et al 2011;Chen et al 2011a, b;Ioannou et al 2009;Minh et al 2007;Epifanio et al 2007;Su et al 2006;Anta et al 2002;Aknin et al 1998;Morris et al 1998;He et al 1995;Lopp et al 1994;Koljak et al 1993;Ochi et al 1991;Fusetani et al 1989;Bonini et al 1983) and sponges (Van Altena et al 1999;De Rosa et al 1999;Rueda et al 1998;Lu and Faulkner 1997;Reddy et al 1997;Adinolfi et al 1994;Li et al 1994;Migliuolo et al 1992, Migliuolo et al 1991Capon and Faulkner 1985). In addition, 9,11-secosterols have been reported to display diverse bioactivities including cytotoxicity against cancer cell lines (Huang et al 2012;Cheng et al 2011;Chen et al 2011a, b;Su et al 2006;Morris et al 1998;Rueda et al 1998), anti-proliferative effects Inho Yang and Hyukjae Choi have contributed equally to this work.…”

“…against cancer cells (Ioannou et al 2009;He et al 1995;Lopp et al 1994;Koljak et al 1993), stimulation of bone formation (Minh et al 2007), fish feeding deterrence for coral and coral-associated algae (Epifanio et al 2007), protein kinase C inhibition (He et al 1995), anti-inflammatory activity (Huang et al 2012;He et al 1995), brine shrimp toxicity (Ochi et al 1991;De Rosa et al 1999), inhibition of starfish embryo cell division (Fusetani et al 1989), antifungal activity (Li et al 1994), and ichthyotoxicity (Capon and Faulkner 1985).…”

Natural Product Chemistry of Gorgonian Corals of the Family Plexauridae Distributed in the Indo-Pacific Ocean

“…A novel 9,10-secosterol, astrogorgiadiol ( 1 ), and a new eunicellin-based diterpenoid, astrogorgin ( 2 ), along with a known eunicellin, ophirin ( 3 ), were isolated from the gorgonian Astrogorgia sp., collected at Okino-shima Island off Shikoku, Japan [2] (Table 1). The structures of new metabolites 1 and 2 were established by spectroscopic methods and by comparison of the spectral data with those of related analogs.…”

Secondary Metabolites from the South China Sea Invertebrates: Chemistry and Biological Activity

“…Four diterpenoids belonging to the eunicellane class, ophirin (753), calicophirin B (754), and two analogues (755, 756) were isolated from the mantle organism of arminids Dermatobranchus ornatus which had not been previously studied [312]. Ophirin (753) and calicophirin B (754) inhibited the growth of the silkworm Bombyx mori L. [313] and the cell division in the eggs of the starfish (Asterina pectinifera) [314]. These compounds are also moderately cytotoxic and toxic to the brine shrimp [315].…”