In this article, we present the results of astronomical seeing measurements conducted at the Maidanak observatory and the influence of meteorological parameters on astronomical seeing. A differential image motion monitor (DIMM) was used to measure astronomical seeing. Astronomical seeing observations were made between 2018–2022, mainly in the summer and autumn months. A total of 266 night observations were conducted between 2018 and 2022. For the whole time frame, the median seeing value was 0.69 arc seconds. With a median value of 0.65″, 2019 is the year with the best seeing, and 2021 has the worst seeing (0.71″). Analysis of long-term variations of the amount of clear time revealed a small trend of decrease in the amount. The correlation between the meteorological parameters and seeing was analyzed. It was determined that the meteorological parameters with the greatest impact on the seeing are wind speed and nighttime temperature variation. The correlation coefficient was equal to 13% and 21% for both quantities. It was found that wind direction and temperature have a relatively weak correlation with astronomical seeing.