Asymmetric Dimethylarginine and Its Relation as a Biomarker in Nephrologic Diseases

Sitar, Mustafa Erinç

doi:10.4137/bmi.s38434

Cited by 14 publications

(13 citation statements)

References 71 publications

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“…The more severe the kidney damage higher the value of Uacr and ADMA levels. [19][20][21] In patients with DM an increased of ADMA levels can occur but in this study, the majority of subjects in the DM group of non-DN (81.5%) had normal ADMA levels. Normal ADMA levels can be caused by the use of antioxidant drugs, estrogen, aspirin and vitamin A but the mechanism is unclear.…”

Section: Resultscontrasting

confidence: 53%

Differences of Asymmetric Dimethyl Arginine Level in Patients With Diabetic Nephropathy and Non-Diabetic Nephropathy

Wisudawati

Rita

Lismayanti

et al. 2018

Indonesian J. Clin. Pathol. Med. Lab.

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Endothelial dysfunction occurs early in Diabetic Nephropathy (DN), characterized by elevated Asymmetric Dimethylarginine (ADMA) levels. Increased ADMA levels may inhibit endothelial Nitric Oxide Synthase (eNOS) production which are required for Nitric Oxide (NO) formation. Decreased NO levels can increase peripheral resistance and exacerbate the endothelial dysfunction. By knowing the difference of ADMA levels in DN and non-DN patients can help the follow-up and management for the progression of endothelial dysfunction. The purpose of this research was to know the difference of ADMA levels in DN and non-DN by a cross-sectional observational analytical method in 53 diabetes mellitus patients at the Dr. Hasan Sadikin Hospital Bandung (December 2016-July 2017). Urine samples were examined to calculate urinary creatinine albumin ratio (uACR) and serum for ADMA levels. Asymetric dimethylarginin was examined by micro ELISA. Most of the subjects were males (60.38%) with the highest age in the range of 55-64 years (45.28%). Increased ADMA levels were found in 100% of DN and 18.5% of non-DN. Median ADMA levels were found in DN 1.01(0.73-2.25) µmol/L and non-DN 0.57(0.27-1.17) µmol/L, showing a significant difference of ADMA levels (p<0.001). High ADMA levels showed endothelial dysfunction in DN. Serum ADMA levels in DN patients were higher than in non-DN.

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Section: Resultscontrasting

confidence: 53%

Differences of Asymmetric Dimethyl Arginine Level in Patients With Diabetic Nephropathy and Non-Diabetic Nephropathy

Wisudawati

Rita

Lismayanti

et al. 2018

Indonesian J. Clin. Pathol. Med. Lab.

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“…ADMA, a naturally occurring molecule, which is found in all human cells and plasma, can diffuse between cells (easy entry-exit), hence, it can be found in tissues and cells, besides being in circulation [25] . ADMA is an endogenous eNOS inhibitor whose accumulation leads to eNOS uncoupling, subsequent reduction in NO production and endothelial dysfunction [26] . Additionally, ADMA is not only a biomarker, but also a mediator of OS.…”

Section: Discussionmentioning

confidence: 99%

Forskolin attenuates doxorubicin-induced accumulation of asymmetric dimethylarginine and s-adenosylhomocysteine via methyltransferase activity in leukemic monocytes

Ramachandran

Loganathan

Cheeran

et al. 2018

Leukemia Research Reports

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Doxorubicin (DOX) is an antitumor drug, associated with cardiomyopathy. Strategies to address DOX-cardiomyopathy are scarce. Here, we identify the effect of forskolin (FSK) on DOX-induced-asymmetric-dimethylarginine (ADMA) accumulation in monocytoid cells. DOX-challenge led to i) augmented cytotoxicity, reactive-oxygen-species (ROS) production and methyltransferase-enzyme-activity identified as ADMA and s-adenosylhomocysteine (SAH) accumulation (SAH-A). However, except cytotoxicity, other DOX effects were decreased by metformin and FSK. FSK, did not alter the DOX-induced cytotoxic effect, but, decreased SAH-A by >50% and a combination of three drugs restored physiological methyltransferase-enzyme-activity. Together, protective effect of FSK against DOX-induced SAH-A is associated with mitigated methyltransferase-activity, a one-of-a-kind report.

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“…The literature comprises numerous studies investigating the relation of ADMA, which is a NO inhibitor, with ED and atherosclerosis. Experimental studies have demonstrated the relationship between the chronic ADMA increase and development of atherosclerosis and nephropathy . In addition, elevated ADMA concentrations were found to be associated with cardiovascular diseases and all‐cause mortality in ESRD and non‐diabetic CKD patients .…”

Section: Discussionmentioning

confidence: 99%

Relation of Serum ADMA, Apelin‐13 and LOX‐1 Levels with Inflammatory and Echocardiographic Parameters in Hemodialysis Patients

Doğan

Yeti̇m

et al. 2017

Ther Apher Dial

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Cardiovascular diseases are the leading causes of mortality in patients with chronic kidney disease. Nitric oxide has a critical role in both endothelial dysfunction and the atherosclerosis process. We aimed to investigate the relationships between serum asymmetric dimethyl arginine (ADMA), LOX-1, and Apelin-13 levels, which are known to act over nitric oxide with endothelial dysfunction and cardiac morphology as well as with each other in hemodialysis patients. The study comprised a total of 120 patients (53 females and 67 males) receiving hemodialysis three times a week for at least 6 months and an age-gender matched control group (55 females and 58 males). Serum ADMA, LOX-1, and Apelin-13 levels were measured using the ELISA technique. Echocardiography, 24-h blood pressure monitoring by the Holter and carotid artery intima-media thickness (CIMT) measurement was performed on all of the included subjects. The associations between serum ADMA, LOX-1, and Apelin-13 levels with CIMT, echocardiographic parameters [left ventricular mass (LVM) and left ventricular mass index (LVMI)], and inflammatory markers [high sensitive C-reactive protein (hsCRP) and neutrophil lymphocyte ratio (NLR)] were evaluated by correlation analysis. Serum ADMA, Apelin-13, and LOX-1 levels were significantly higher in the hemodialysis group than the controls (P < 0.001, P < 0.001, and P < 0.001, respectively). CIMT, hsCRP, and NLR levels were also significantly higher in the hemodialysis group (P < 0.05, P < 0.001, P < 0.001, respectively). Significant correlations were observed among the serum ADMA, Apelin-13, and LOX-1 levels. Moreover, notably positive correlations were found between these three biochemical markers and LVM, LVMI, hsCRP, and CIMT. Serum ADMA, Apelin-13, and LOX-1 levels can be indicators not only for the inflammatory process but also for the pathogenesis of cardiovascular diseases in hemodialysis patients.

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Asymmetric Dimethylarginine and Its Relation as a Biomarker in Nephrologic Diseases

Cited by 14 publications

References 71 publications

Differences of Asymmetric Dimethyl Arginine Level in Patients With Diabetic Nephropathy and Non-Diabetic Nephropathy

Differences of Asymmetric Dimethyl Arginine Level in Patients With Diabetic Nephropathy and Non-Diabetic Nephropathy

Forskolin attenuates doxorubicin-induced accumulation of asymmetric dimethylarginine and s-adenosylhomocysteine via methyltransferase activity in leukemic monocytes

Relation of Serum ADMA, Apelin‐13 and LOX‐1 Levels with Inflammatory and Echocardiographic Parameters in Hemodialysis Patients

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