Asymmetric membrane in membrane capsules: A means for achieving delayed and osmotic flow of cefadroxil

Philip, Anil K.; Pathak, Kamla; Shakya, Pragati

doi:10.1016/j.ejpb.2007.12.011

Cited by 33 publications

(13 citation statements)

References 13 publications

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“…A similar effect had been repeated from earlier studies that emerged from our laboratory for ketoprofen, flurbiprofen, and cefadroxil. (26)(27)(28). In group II, formulation F6 showed maximum drug release (53.52%) while F5 displayed minimum drug release of 44.57% at the 12th hour.…”

Section: Discussionmentioning

confidence: 96%

Solubility-Modulated Asymmetric Membrane Tablets of Triprolidine Hydrochloride: Statistical Optimization and Evaluation

2011

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Abstract. The aim of the present study was to develop asymmetric membrane (AM) tablets for controlled delivery of highly water-soluble antihistaminic drug triprolidine hydrochloride. The solubility of triprolidine hydrochloride was modulated through the incorporation of coated sodium chloride crystals encapsulated with asymmetric membrane coating polymer, cellulose acetate butyrate. Formulation of AM tablets was based on a 2 3 factorial design to study the effect of formulation variables, namely, polymer concentration, level of pore former, and amount of osmogen on the in vitro release. Core tablets prepared by wet granulation and coated with asymmetric membrane by a dip coating method were evaluated. Statistical analysis was done with the Design Expert Software 8.0.2 (USA), and the polynomial equation generated by Pareto charts was used for validation of the experimental design. The interaction chart and response surface plots deduced the simultaneous effect of independent variables on in vitro drug release. The in vitro drug release was inversely proportional and directly related to the level(s) of polymer and pore former in the membrane, respectively. The level of osmogen not only increased the osmotic pressure but also controlled the drug release due to a common ion effect. The drug release of the optimized formulation (F6) followed zero-order kinetics, which would be capable of reducing the administration, and was stable over 3 months. SEM photographs revealed asymmetry in membrane structure.KEY WORDS: asymmetric membrane; coated sodium chloride; cellulose acetate butyrate; solubility modulation; 2 3 factorial design.

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Section: Discussionmentioning

confidence: 96%

Solubility-Modulated Asymmetric Membrane Tablets of Triprolidine Hydrochloride: Statistical Optimization and Evaluation

2011

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“…The situation is further complicated by the varied approaches that have been used for achieving colon targeting. The most commonly used strategies to formulate colon-specific drug delivery systems include timed release systems, prodrugs, pH sensitive polymer coating and colonic microflora activated delivery systems (Gulati et al, 2012;Rubinstein, 1995;Yang et al, 2002;Muraoka et al, 1998;Philip et al, 2008). Among these, the microflora activated delivery systems have been found to be quite promising.…”

Section: Introductionmentioning

confidence: 97%

“…The methods that have been reported for evaluation of colon targeted delivery systems include triggering by enzymes (Philip et al, 2008;Fetzner et al, 2004;Macfarlane et al, 1989;Maculotti et al, 2009;Maestrelli et al, 2008;Liu et al, 2012;Semde et al, 2000a,b Omar et al, 2007Jain et al, 2007a,b et al, 2010), rat caecal contents (Rubinstein et al, 1993;Jain et al, 2007a,b;Watanabe et al, 1998;Takemura et al, 2000;Tiwari et al, 2011;Shukla et al, 2012Shukla et al, , 2011Krishnaiah et al, 2001;Shyale et al, 2005;Ravi et al, 2008;Varshosaz et al, 2010;Singhal et al, 2011;Wei et al, 2007;Seal and Mathers, 2001), human faecal slurries (Salunkhe and Kulkarni, 2008;Siew et al, 2000Siew et al, , 2004McConnel et al, 2007;Karrout et al, 2009;Krenzlin et al, 2011), and multi stage compound culture system (Yang, 2008;Kotla et al, 2014;Schacht et al, 1996). Despite a large number of research reports on microbially triggered delivery systems for colon delivery, no such product is commercially available.…”

Section: Introductionmentioning

confidence: 99%

A novel dissolution method for evaluation of polysaccharide based colon specific delivery systems: A suitable alternative to animal sacrifice

Singh

Yadav

Prudhviraj

et al. 2015

European Journal of Pharmaceutical Sciences

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“…The capsules were observed visually for release of any colored dye. [17,18] Preparation and comparative evaluation of plain and asymmetric membrane films of CAB Plain films of CAB in the concentration of 12% w/v were prepared with varying concentrations of PG such as 10%, 15% and 20% v/v in ethanol and acetone. The polymer solution was then casted on three different petri dishes and dried at room temperature for 8 h. Asymmetric membrane films of CAB-12 were prepared with above concentrations and cast.…”

Section: Osmotic Release Studymentioning

confidence: 99%

Development of asymmetric membrane capsules of metformin hydrochloride for oral osmotic controlled drug delivery

Srinivasan¹,

Deveswaran²,

Veerbadraiah³

et al. 2014

Asian J Pharm

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A symmetric membrane capsules are one of the novel osmotic delivery devices which offer the delivery of a wide range of drugs in a controlled manner. In the present work, we developed a semi-automatic process by fabricating a hydraulic assisted mechanical robotic arm for the manufacturing of asymmetric membrane capsules and the process was validated in comparison with the manual procedure of manufacturing. The capsule walls were made by dip coating phase inversion process using cellulose acetate butyrate as polymer and propylene glycol as plasticizer/pore forming agent. The comparative examination of physical parameters in manual and semi-automatic process confirmed the consistency, reproducibility and efficiency of the semi-automatic process over manual procedure. The resulting asymmetric membrane wall was evaluated by scanning electron microscopy studies revealed the thin dense region supported on a thicker porous region. Fourier transform infrared studies showed phase inversion of the asymmetric membrane as compared to plain membrane. Osmotic release study and in vitro behavior was studied for controlled delivery of metformin hydrochloride as a model drug. In vitro release studies of the formulations showed that drug release was dependent on the concentration of pore forming agent, level of osmogents and independent of the media pH and agitation. The effect of the process variables on the drug release was optimized using 2 3 full factorial design and the release kinetics of the optimized formulation confirmed zero order kinetics with a controlled drug delivery of 13 h and the mechanism of drug release was found to be super case II transport.

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Asymmetric membrane in membrane capsules: A means for achieving delayed and osmotic flow of cefadroxil

Cited by 33 publications

References 13 publications

Solubility-Modulated Asymmetric Membrane Tablets of Triprolidine Hydrochloride: Statistical Optimization and Evaluation

Solubility-Modulated Asymmetric Membrane Tablets of Triprolidine Hydrochloride: Statistical Optimization and Evaluation

A novel dissolution method for evaluation of polysaccharide based colon specific delivery systems: A suitable alternative to animal sacrifice

Development of asymmetric membrane capsules of metformin hydrochloride for oral osmotic controlled drug delivery

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