Asymmetric multicomponent copper catalyzed synthesis of chiral propargylamines

Novel Silver(I) Ion Selective PVC Membrane Electrode Based on the Schiff Base (N2E,N2'E)-N2,N2'-Bis(Thiophen-2-ylmethylene)-1,1'-Binaphthyl-2,2'-Diamine

“…-bis(thiophen-2-ylmethylene)-1,1'-binaphthyl-2,2'-diamine tested as a carrier of silver ions was synthesized according to a similar procedure described previously. 21 The precipitate was collected from ether by filtration. The product was recrystallized from ethanol and dried under reduced pressure at 40 o C; 90% yield, as shown in Figure 1.…”

Recent Developments in Asymmetric Alkynylation of Imines

“…However, methyl propiolate and trimethylsilylacetylene reacted with low yields and ee's. The same catalytic system was applied by these authors to a three-component version of the reaction [52]. Ligand 125, derivative of 2-hydroxybenzaldehyde, gave the best results in this case providing compound 83 (R 1 = R 2 = Ph) in quantitative yield and 75% ee (lower than in the twocomponent reaction, 81% ee).…”

Green Copper Catalysis in Enantioselective Domino Reactions

“…This process provided the corresponding alkynylamines 95 with moderate to excellent yields (56-99%) and good to very high enantioselectivities (77-99% ee), as shown in Scheme 30. The same year, Benaglia et al studied the enantioselective three-component reaction of phenylacetylene with primary amines and aldehydes catalyzed by copper complexes of BINOL-derived bis-imines, providing moderate enantioselectivities (≤75% ee) [38]. [39].…”