Asymmetric Organocatalysis with Chiral Covalent Organic Frameworks

Abstract

Inspired by Mother Nature, the use of chiral covalent organic frameworks as heterogeneous asymmetric organocatalysts has arisen over the last decade as a new method in enantioselective synthesis. In this Short Review, sophisticated design of these polymeric materials and their application in asymmetric organocatalysis will be discussed.

Stabilized Chiral Organic Material Containing BINAP Oxide Units as a Heterogeneous Asymmetric Organocatalyst for Allylation of Aldehydes

“…However, the limited stability of common catalysts and their difficult recyclability appear as some of their main limitations. Therefore, the quest for recyclable asymmetric organocatalytic systems is an important target in the field of heterogeneous catalysis. , Toward this goal, an emerging strategy consists of incorporating asymmetric organocatalytic building blocks on extended organic materials such as porous aromatic frameworks (PAFs), covalent organic frameworks (COFs), and other porous organic polymers (POPs) . Design of reticular materials offers many possibilities for the assembly of complex organic fragments into organized frameworks that display exceptional features, such as well-defined channels and tunability of chemical composition.…”

Porous Aromatic Frameworks Containing Binaphthyl-Dihydroazepine Units (Cbapafs) as Catalytic Supports for Asymmetric Reactions

“…In the recent decade, different porous materials (porous organic frameworks, POPs, covalent organic frameworks, COFs or metal organic frameworks, MOFs) with high porosity have been developed and used in fields, such as, gas adsorption and storage, separation, drug delivery, sensing, and catalysis [6][7][8]. The heterogenization of soluble chiral catalysts on these materials has become very interesting and the last advances in this field have been reported for different authors [9][10][11][12][13][14][15][16][17]. POPs are formed by stable covalent bonds and in particular when formed by only aromatic rings linked by single carbon-carbon bond are named porous aromatic framewoks (PAFs) and have been applied in different fields [18,19].…”