Asymmetric reactions. XXXV. Absolute configurations of (S)-(+)-α-isopropylphenylacetic acid and (R)-(+)-1-phenyl-2-methylpropylamine

Exploring the Crystal Landscape of 3-Methyl-2-phenylbutyramide: Crystallization of Metastable Racemic Forms from the Stable Conglomerate

“…Calcd for C 11 H 15 NO: C, 74.54; H, 8.53; N, 7.90; Found: C, 74.29; H, 8.62; N, 7.98, mp: 105–107 °C. All spectroscopic details for 1 agreed with those previously reported . Crystals suitable for single crystal analysis were grown from ethanol and called Form I.…”

Asymmetric synthesis of N-protected amino acids by the addition of organolithium carboxyl synthons to ROPHy/SOPHy-derived aldoximes and ketoximesChiral oxime ethers in asymmetric synthesis. Part 6.1

“…The last dichloromethane organic layers were combined, dried (MgSO 4 ), filtered and evaporated in vacuo. The crude product was purified by column chromatography on silica gel, eluting with acetic acid-dichloromethane-light petroleum (1 : 1 : 8) to give the pure product as a colourless oil (40 (7), 114 (18), 108 (31).…”

“…2-Furyllithium was prepared in diethyl ether following a literature protocol. 30 (5), 268 (26), 266 (40), 264 (12), 188 (12), 168 (16), 150 (100), 133 (2), 108 (6), 96 (56), 91 (2).…”

“…(R )-(؉)-N-Acetyl-2-methyl-1-phenylpropylamine 4b. Obtained by the zinc mediated N-O bond cleavage and subsequent N-protection of hydroxylamine 3d as a colourless solid (38% over two steps, 98% ee); mp 135-136 ЊC (lit., 39 mp 120 ЊC; lit., 40 mp 119-120 ЊC); [α] 24 D ϩ105.5 (c 1.1, CHCl 3 ) (lit., 39 [α] 20 D ϩ135 (c 3.8, MeOH); lit., 40 [α] D ϩ72. (6), 141 (18), 108 (2), 106 (7), 94 (2), 77 (13), 72 (3).…”