Asymmetric resorbable‐based dental barrier membrane for periodontal guided tissue regeneration and guided bone regeneration: A review

Abstract

Guided tissue regeneration (GTR) and guided bone regeneration (GBR) are two common dental regenerative treatments targeted at reconstructing damaged periodontal tissue and bone caused by periodontitis. During GTR/GBR treatment, a barrier membrane is placed in the interface between the soft tissue and the periodontal defect to inhibit soft tissue ingrowth and creating a space for the infiltration of slowgrowing bone cells into the defect site. Recently, asymmetric resorbable-based barrier membrane has received a considerable attention as a new generation of GTR/GBR membrane. Despite numerous literatures about asymmetric-based membrane that had been published, there is lacks comprehensive review on asymmetric barrier membrane that particularly highlight the importance of membrane structure for periodontal regeneration. In this review, we systematically cover the latest development and advancement of various kinds of asymmetric barrier membranes used in periodontal GTR/GBR application. Herein, the ideal requirements for constructing a barrier membrane as well as the rationale behind the asymmetric design, are firstly presented. Various innovative methods used in fabricating asymmetric barrier membrane are being further discussed. Subsequently, the application and evaluation of various types of asymmetric barrier membrane used for GTR/GBR are compiled and extensively reviewed based on the recent literatures reported. Based on the existing gap in this field, the future research directions of asymmetric resorbable-based barrier membrane such as its combination potential with bone grafts, are also presented.

A comparative in vitro and in vivo study of porcine‐ and bovine‐derived non‐cross‐linked collagen membranes

“…Studies have shown that barrier membranes are crucial for proper bone regeneration during the GBR process, as they need to occlude the faster growing soft tissue to invade into the bone defect underneath, thus providing the appropriate space, time for the comparatively less slowly growing bone tissue to regenerate 4 . To achieve optimal bone regeneration, GBR membranes should possess good biocompatibility, proper mechanical characteristics for space maintenance, ideal resorption time to prevent epithelial cell migration into the bone defect and provide enough time for bone regeneration, and the ability to stimulate bone formation 5,6 …”

“…Absorbable membrane does not bring additional trauma to the patients. The key factors affecting the usage of absorbable membranes include absorbing rate, compatibility, rigidity, porosity, and so forth 5 . Synthetic absorbable polymers including members of aliphatic polyesters and their copolymers have been used as GBR membranes, including poly lactic acid and poly lactic‐co‐glycolic acid 11,12,13 .…”

Membrane Surface Modification via In Situ Grafting of GO/Pt Nanoparticles for Nitrate Removal with Anti-Biofouling Properties

“…Upon immersion of the casting solution in the coagulation bath, the interfacial surface is exposed to the coagulant. The exchange rate of solvent and coagulant is so high that the polymer precipitation and solidifying happen almost concurrently, which leads to the generation of a dense skin layer on the top surface [ 38 , 39 ]. On the other hand, the weak affinity of the PSF to water as the nonsolvent results in a shorter time of solvent exchange and a greater exchange rate caused by the larger finger-shape pores [ 40 ].…”

Modularized bioceramic scaffold/hydrogel membrane hierarchical architecture beneficial for periodontal tissue regeneration in dogs

“…Additionally, pore size is closely related to both the cell occlusive property and PDL/bone regeneration. Previous studies have demonstrated that macroporous design (pore size > 100 μm) is favorable to provide adequate space for osteogenesis cell ingrowth, which leads to greater bone regeneration compared to microporous membrane [40,41]. However, as for barrier functionality, it has been reported that membranes with pores size exceeding 100 μm may permit soft-tissue invasion [42].…”

“…2K). Moreover, it is well agreed that the barrier biomaterials should be biocompatible with the endogenous cells to support tissue healing process [40]. GelMA and Si-HPMC are both biodegradable and injectable hydrogel that is nontoxic, and have been widely studied for tissue engineering or drug delivery applications [49,50].…”