Asymmetric Synthesis of Cyanohydrins

Abstract

Catalysts and cyanide sources for asymmetric synthesis of cyanohydrins are reviewed with 175 references.

Enantioselective direct Michael addition of cyanohydrin ether derivatives to enones catalyzed by chiral bis(guanidino)iminophosphorane organosuperbase

“…1a ). 2 Indeed, successful examples of enantioselective variants have been reported using a variety of chiral metal catalysts 3 and a limited number of organocatalysts, 4 and these have led to the development of efficient methods for the construction of a tetrasubstituted cyanohydrin unit in an enantioenriched form. However, in principle, those methods deal with the formation of a single stereogenic center and not the construction of multiple stereogenic centers in the bond formation step or the formation of multifunctionalized carbon frameworks.…”