Asymmetric Synthesis of Seven‐Membered Rings with More Than One Heteroatom

Enantioselective amine α-functionalization via palladium-catalysed C–H arylation of thioamides

“…1a) and auxiliaries for asymmetric transformations, with the stereochemistry at that position having a significant impact on the compound's bioactivity or ability to promote asymmetric induction. Forging a carbon–carbon bond asymmetrically at this position is a long-standing challenge in organometallic chemistry 1-4 . In his pioneering work, Beak reported the carbamate directed asymmetric α -lithiation of N -heterocycles using a chiral diamine, ( – )-sparteine, and subsequent trapping with electrophiles 5 .…”

Highly Selective Copper‐Catalyzed Asymmetric [3+2] Cycloaddition of Azomethine Ylides with Acyclic 1,3‐Dienes

“…[1] Consequently, the development of robust procedures that enable their preparation with full selectivity control is a major synthetic challenge [2] with great value in chemical biology research. [3] One of the most powerful approaches for the preparation of pyrrolidines is the 1,3-dipolar cycloaddition of azomethine ylides with activated olefins.…”

Selective C–C bond formation from rhodium-catalyzed C–H activation reaction of 2-arylpyridines with 3-aryl-2H-azirines

“…Controlling the chemo-, regio- and stereoselectivities of reactions is of central importance in general, but particularly so in organic chemistry. 1 And C–H bond activation reactions 2 are among the most desirable to carry out with high degrees of selectivity and significant research efforts were made in the past to couple C–H activation to C–C and C–N bond forming transformations. Alkyl and aryl azides featured prominently as valuable reagents in this endeavor and many C–N bond forming reagents based on C–H activation reactions have been developed ( Scheme 1 , eqn (1) ).…”