Asymmetric Two‐Center Catalysis

Abstract

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Chiral ion pairs in catalysis: lithium salts of chiral metallocomplex anions as catalysts for asymmetric C–C bond formation

“…[3][4][5] A few examples exist of asymmetric reactions catalyzed by salts of alkali metal cations with chiral counteranions. [6][7][8][9] reported the synthesis of bimetallic rare earth-alkali metal BINOL complexes and their successful application in catalytic asymmetric Michael additions and aldol reactions. 6 A mono-lithium BINOL salt in organic solvent was used in the asymmetric trimethylsilylcyanation of aldehydes by Kagan and Holmes.…”

“…[6][7][8][9] reported the synthesis of bimetallic rare earth-alkali metal BINOL complexes and their successful application in catalytic asymmetric Michael additions and aldol reactions. 6 A mono-lithium BINOL salt in organic solvent was used in the asymmetric trimethylsilylcyanation of aldehydes by Kagan and Holmes. 7a Ishihara et al studied the same reaction in water as a cosolvent 7b and described the enantioselective cyanosilylation of ketones in the presence of chiral lithium salts of phosphoric acids.…”