Asymmetric visual field loss and retrobulbar haemodynamics in primary open-angle glaucoma

Plange, Niklas; Kaup, M.; Arend, Oliver; Remky, Andreas

doi:10.1007/s00417-005-0227-9

Cited by 57 publications

(55 citation statements)

References 34 publications

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“…The rate of progression of VF defects also relates to blood flow, with more rapid progression correlating with a lower CRA velocity and a higher RI in the CRA [61,63]. In patients with asymmetric VF defects, the more severely affected eye has been shown to have reduced blood flow velocities in the PSV of the CRA and OA, and in the EDV of the CRA [64,67]. Furthermore, in patients with unilateral VF loss, the RI in the CRA of both eyes was higher than that in controls [64].…”

Section: Retrobulbar Blood Flowmentioning

confidence: 99%

Glaucoma and ocular blood flow: an anatomical perspective

Siesky

Harris²,

Amireskandari

et al. 2012

Expert Review of Ophthalmology

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Section: Retrobulbar Blood Flowmentioning

confidence: 99%

Glaucoma and ocular blood flow: an anatomical perspective

Siesky

Harris²,

Amireskandari

et al. 2012

Expert Review of Ophthalmology

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“…[7][8][9][10] Evidence for decreased optic nerve blood flow in relation to visual field damage has been reported in glaucoma patients. [11][12] Nevertheless, based on available data, this is the first study to evaluate the relationship between RBF velocities and the development of glaucoma based on structural changes of the ONH over a long time period.…”

Section: Methodsmentioning

confidence: 99%

Predictive Value of Retrobulbar Blood Flow Velocities in Glaucoma Suspects

Calvo

Ferreras

Polo

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To determine whether retrobulbar blood flow (RBF) velocities are predictive of conversion to glaucoma. METHODS.A total of 262 glaucoma suspects were prospectively selected. Participants had normal visual field, increased intraocular pressure, and glaucomatous optic disc appearance at baseline. Topographic analysis of the optic nerve head was performed using a confocal laser scanning ophthalmoscope and the blood flow velocity of retrobulbar vessels was measured by color Doppler imaging. Conversion to glaucoma was assessed according to the changes in the color-coded Moorfields Regression Analysis (MRA) classification of the confocal laser scanning system during a 48-month follow-up period. Survival curves and hazard ratios (HRs) for the association between RBF parameters and conversion to glaucoma were calculated.RESULTS. End-diastolic velocity and mean velocity in the ophthalmic artery were reduced in subjects that converted to glaucoma based on MRA (36 individuals, 13.7%), while resistivity (RI) and pulsatility indices were increased in the same vessel. Patients with RI values lower than 0.75 in the ophthalmic artery had a survival rate (MRA-converters versus nonconverters) of 93.9%, whereas individuals with RI values greater than 0.75 had a survival rate of 81.7% (HR ¼ 3.306; P ¼ 0.002).CONCLUSIONS. Abnormal RBF velocities measured by color Doppler ultrasound may be a risk factor for conversion to glaucoma. An RI value higher than 0.75 in the ophthalmic artery was associated with the development of glaucoma.

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“…[13][14][15][16][17][18][19] The blood flow velocities of retrobulbar vessels have been correlated to functional defects in glaucoma 20,21 and are associated with interocular differences in asymmetric visual field defects. 22 In addition, retrobulbar blood flow velocities are linked to perfusion deficits of the optic nerve head 13 and retina 23 in glaucoma. However, a considerable overlap of the flow velocities is present in all studies that compared NTG patients with controls.…”

Section: Introductionmentioning

confidence: 99%

Performance of colour Doppler imaging discriminating normal tension glaucoma from healthy eyes

Plange

Kaup

Weber

et al. 2007

Eye

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Purpose Previous studies have shown decreased retrobulbar blood flow in normal tension glaucoma (NTG) compared to healthy controls. This study evaluates the ability of colour Doppler imaging (CDI) to identify patients with NTG. Methods Sixty-two patients with untreated NTG (mean age 57714 years) and 40 agematched controls (mean age 5879 years) were included in a prospective cross-sectional institutional study. Peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive indices (RI ¼ (PSV-EDV)/PSV) of the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (PCAs) were measured by means of CDI. Using receiver operating characteristic (ROC) curves, sensitivity was determined at 90% specificity. Results Patients with NTG showed significantly decreased PSV (Po0.0001) and EDV (Po0.0001) of the CRA, significantly decreased EDV of the nasal (P ¼ 0.004) and temporal (P ¼ 0.002) PCA, and significantly increased RI of the temporal (P ¼ 0.003) PCAs compared to healthy controls. Sensitivity values at 90% specificity were calculated: PSV of the CRA, 30.6%; EDV of the CRA, 48.4%; EDV of the nasal PCA, 43.9%; EDV of the temporal PCA, 45.9%; and RI of the temporal PCA, 39.3%. Conclusions The power to identify NTG using CDI reaches 48% sensitivity at 90% specificity. Further longitudinal studies are needed to determine the prognostic value of CDI in glaucoma.

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Asymmetric visual field loss and retrobulbar haemodynamics in primary open-angle glaucoma

Abstract: Patients with asymmetric glaucomatous visual field loss exhibit asymmetric flow velocities of the CRA and OA. Patients with more severe damage display reduced flow velocities in retrobulbar vessels in POAG.

Cited by 57 publications

References 34 publications

Glaucoma and ocular blood flow: an anatomical perspective

Glaucoma and ocular blood flow: an anatomical perspective

Predictive Value of Retrobulbar Blood Flow Velocities in Glaucoma Suspects

Performance of colour Doppler imaging discriminating normal tension glaucoma from healthy eyes

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