Asymmetrical cerebral perfusion demonstrated by noninvasive arterial spin-labeling perfusion imaging in a patient with corticobasal degeneration

Dashjamts, Tuvshinjargal; Yamada, Takashi; Hiwatashi, Akio; Yamashita, Koji; Abe, Koichiro; Ohyagi, Yasumasa; Kira, Jun‐ichi; Honda, Hiroshi

doi:10.1007/s11604-009-0382-8

Cited by 8 publications

(6 citation statements)

References 7 publications

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“…205 ASL studies in CBD have also shown reduced cerebral perfusion in the right hemisphere. 206 SPECT studies have demonstrated reductions in neurotransmitters in both CBD and PSP, with reduced dopaminergic transporter binding in the striatum and reduced acetylcholine transporter binding in the anterior cingulate and thalamus relative to HC. 207,208 FDG PET studies in CBD and PSP also showed cerebral hypometabolism, with reduced metabolism in cortical regions contralateral to the physically affected side in CBD and hypometabolism in the prefrontal cortex, caudate, thalamus, and mesencephalon in PSP.…”

Section: Frontotemporal Dementiamentioning

confidence: 99%

Neuroimaging Biomarkers of Neurodegenerative Diseases and Dementia

2013

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Neurodegenerative disorders leading to dementia are common diseases that affect many older and some young adults. Neuroimaging methods are important tools for assessing and monitoring pathological brain changes associated with progressive neurodegenerative conditions. In this review, the authors describe key findings from neuroimaging studies (magnetic resonance imaging and radionucleotide imaging) in neurodegenerative disorders, including Alzheimer’s disease (AD) and prodromal stages, familial and atypical AD syndromes, frontotemporal dementia, amyotrophic lateral sclerosis with and without dementia, Parkinson’s disease with and without dementia, dementia with Lewy bodies, Huntington’s disease, multiple sclerosis, HIV-associated neurocognitive disorder, and prion protein associated diseases (i.e., Creutzfeldt-Jakob disease). The authors focus on neuroimaging findings of in vivo pathology in these disorders, as well as the potential for neuroimaging to provide useful information for differential diagnosis of neurodegenerative disorders.

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Section: Frontotemporal Dementiamentioning

confidence: 99%

Neuroimaging Biomarkers of Neurodegenerative Diseases and Dementia

2013

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“…Subjects with various disorders of focal and global hypoperfusion have been evaluated with the ASL method, including cases of acute and chronic cerebral ischemia, seizure, hydrocephalus, vasculitis, aging, and drug‐induced conditions (7). ASL has also been demonstrated to measure regional CBF (rCBF) in neurodegenerative diseases such as mild cognitive impairment (MCI) (8), Alzheimer's disease (8, 9), frontotemporal dementia (10), amyotrophic lateral sclerosis (11), and corticobasal degeneration (12). However, to the best of our knowledge, ASL has not been used to measure rCBF in PD or PDD.…”

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confidence: 99%

Posterior hypoperfusion in parkinson's disease With and without dementia measured with arterial spin labeling MRI

Kamagata

Motoi

Hori

et al. 2011

Magnetic Resonance Imaging

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Purpose: To determine whether quantitative arterial spin labeling (ASL) can be used to evaluate regional cerebral blood flow in Parkinson's disease with dementia (PDD) and without dementia (PD).Materials and Methods: Thirty-five PD patients, 11 PDD patients, and 35 normal controls were scanned by using a quantitative ASL method with a 3 Tesla MRI unit. Regional cerebral blood flow was compared in the posterior cortex using region-of-interest analysis.Results: PD and PDD patients showed lower regional cerebral blood flow in the posterior cortex than normal controls (P ¼ 0.002 and P ¼ 0.001, respectively, analysis of variance with a Bonferroni post hoc test).Conclusion: This is the first study to detect hypoperfusion in the posterior cortex in PD and PDD patients using ASL perfusion MRI. Because ASL perfusion MRI is completely noninvasive and can, therefore, safely be used for repeated assessments, this method can be used to monitor treatment effects or disease progression in PD.

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“…Although most movement disorder perfusion analysis has been focused on the topic of PD or related syndromes, there has been sporadic reporting on other diseases, including Huntington's disease and corticobasal degeneration .…”

Section: Neuropsychiatric Applicationsmentioning

confidence: 99%

Clinical applications of arterial spin labeling

2013

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MR arterial spin labeling is primarily applied as a neuroimaging method to measure cerebral blood flow. As this technique becomes more widely available, a basic understanding of the clinical applications is necessary for optimal utilization in the setting of patient care. This review focuses on the use of arterial spin labeling imaging for the evaluation of cerebrovascular disease, brain tumors and neuropsychiatric illness.

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Asymmetrical cerebral perfusion demonstrated by noninvasive arterial spin-labeling perfusion imaging in a patient with corticobasal degeneration

Cited by 8 publications

References 7 publications

Neuroimaging Biomarkers of Neurodegenerative Diseases and Dementia

Neuroimaging Biomarkers of Neurodegenerative Diseases and Dementia

Posterior hypoperfusion in parkinson's disease With and without dementia measured with arterial spin labeling MRI

Clinical applications of arterial spin labeling

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