Asymmetrical effects of vagus nerves on functional parameters of rat heart in postnatal ontogeny

Ситдиков, Ф. Г.; Gil'mutdinova, R. I.; Minnakhmetov, R. R.; Зефиров, Т. Л.

doi:10.1007/bf02682086

Cited by 12 publications

(7 citation statements)

References 2 publications

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“…It is logical, therefore, to speculate that the rat model or its age, or both, might not be appropriate for this study. Age-related peculiarities of cardiac function are related to the development of sympathethic and parasympathetic innervation of the heart [30]. A study investigated the age-dependent heart rate after bilateral vagotomy: in 2-week-old rats, bilateral vagotomy reduced the heart rate; the same effect was observed in 3-mo-old rats.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-induced heart rate decrease: role of the vagus nerve

Coiado

Buiochi

O’Brien

2015

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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The goal of this study is to investigate the role of the vagus nerve (VN) in the ultrasound (US)-induced negative chronotropic effect (deceased heart rate). One of the functions of the VN is to mediate lowering of the heart rate. A previous study showed a decrease of ~20% in the heart rate but the mechanism of the effect was not investigated. Sprague Dawley rats (n = 20) were exposed transthoracically to ultrasonic pulses at an approximate duty factor of 1% with sequentially 2.0, 2.5, and 3.0 MPa peak rarefactional pressure amplitudes (PRPAs). The ultrasonic exposure parameters herein were chosen to match those of the previous study to have confidence that an ultrasound-induced negative chronotropic effect would occur. For each of the three PRPA sequences, the pulse repetition frequency (PRF) started slightly greater than the rat’s heart rate and then was decreased sequentially in 1-Hz steps every 10 s (i.e., 6, 5, and 4 Hz for a total duration of 30 s). The experiments were organized in a standard (2 × 2) factorial design with VN (cut versus intact) as one factor and US (on versus off) as another factor. VN (intact/cut) and US (on/off) groups were divided into four groups each consisting of 5 animals: 1) VN intact-US off, 2) VN intact-US on, 3) VN cut-US off, and 4) VN cut-US on. Two-way analysis of variance for repeated measures was used to compare heart rate, cardiac output, systolic volume, ejection fraction, end-diastolic volume, end-systolic volume, respiratory rate, and arterial pressure before and after ultrasound stimulation. In this study, the heart rate decreased ~4% for the non-vagotomy and vagotomy groups. The ultrasound effect was significant for heart rate (p = 0.02) and cardiac output (p = 0.005) at 3 min post US exposure; the vagotomy effect was not significant. For heart rate, the Bonferroni test showed no differences between the four groups. The vagotomy group showed similar ultrasound-induced cardiac effects compared with the non-vagotomy group, suggesting that the vagus nerve is not influenced by the ultrasound exposure procedures. The US application caused a negative chronotropic effect of the rat heart without affecting the hemodynamic conditions. The results at this point are suggestive for an alternative cardiac pacing capability.

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Section: Discussionmentioning

confidence: 99%

Ultrasound-induced heart rate decrease: role of the vagus nerve

Coiado

Buiochi

O’Brien

2015

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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“…Electrodes are then wrapped around the vagus nerve and subcutaneously connected to the battery generator, which delivers intermittentpulsed electrical signals to the vagus nerve. The left vagus nerve is chosen, since it has limited effects on cardiac physiology (57). The stimulation parameters, including the intensity, frequency and timing of stimulation can be programmed remotely by a telemetric wand (58,59).…”

Section: Vagus Nerve Stimulationmentioning

confidence: 99%

Treatment Resistant Depression— Advances in Somatic Therapies

Kennedy

Giacobbe

2007

Annals of Clinical Psychiatry

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“…Most studies were devoted to estimate the effect of sympathectomy on HR [3,4]. Little is known about the response of HR and stroke volume (SV) in sympathectomized animals to various factors [1,9,10].Here we studied changes in SV and HR in intact (IR) and sympathectomized rats (SR) during consecutive and simultaneous bilateral stimulation of the vagus nerves before or after vagotomy and propranolol administration. …”

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confidence: 98%

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confidence: 99%

Parasympathetic cardiac effects in sympathectomized rats

et al. 2007

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In adult sympathectomized rats the right and left vagus nerves exhibited asymmetric effects on heart rate and strength of cardiac contractions. After vagotomy, the heart rate and stroke volume remained high in sympathectomized rats, but returned to normal in intact animals. The sympathetic nervous system plays a role in postvagotomic tachycardia. Sympathectomized rats were characterized by higher reactivity of cardiac beta-adrenoceptors to propranolol compared to intact animals.

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Asymmetrical effects of vagus nerves on functional parameters of rat heart in postnatal ontogeny

Cited by 12 publications

References 2 publications

Ultrasound-induced heart rate decrease: role of the vagus nerve

Ultrasound-induced heart rate decrease: role of the vagus nerve

Treatment Resistant Depression— Advances in Somatic Therapies

Parasympathetic cardiac effects in sympathectomized rats

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