Asymmetrical visual-spatial attentional performance in ADHD: Evidence for a right hemispheric deficit

Carter, Cameron S.; Krener, Penelope; Chaderjian, Marc; Northcutt, Cherise; Wolfe, Virginia

doi:10.1016/0006-3223(94)00217-q

Cited by 120 publications

(88 citation statements)

References 20 publications

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“…[36][37][38] Crucially, children with ADHD are also reported to show a relative inattention to the left side of space, similar to hemi-neglect, suggesting disruption of right hemispheric attentional mechanisms. 39 In this study, we clearly find impaired activation in the right parietal cortex associated with mental rotation/spatial working memory in children with ADHD-CT. This is consistent with our previous study of adolescents with ADHD-CT 3 and with the recent study of Booth et al 20 showing impaired right parietal activation during a visual selective attention task in children with ADHD.…”

Section: Discussionsupporting

confidence: 49%

“…This is also consistent with studies of event-related potentials (ERPs) which have shown reduced amplitudes to attentional orienting cues over posterior brain regions, consistent with dysfunction of the posterior parietal attentional system. [21][22][23] We therefore suggest that right parietal dysfunction in ADHD-CT is development-stage independent, observed both in adolescents 3 and children, and contributes to known clinical and behavioural deficits such as impairments in the control of attention 39 and spatial working memory. 12 The frontal areas of activation in both ADHD-CT and healthy children were considerably less than those in both ADHD-CT and healthy adolescents, Listed are peak voxels (P uncorrected < 0.005) that are located within significant activation clusters (P corrected < 0.05).…”

Section: Discussionmentioning

confidence: 82%

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Right parietal dysfunction in children with attention deficit hyperactivity disorder, combined type: a functional MRI study

et al. 2007

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Attention deficit hyperactivity disorder, combined type (ADHD-CT) is associated with spatial working memory deficits. These deficits are known to be subserved by dysfunction of neural circuits involving right prefrontal, striatal and parietal brain regions. This study determines whether decreased right prefrontal, striatal and parietal activation with a mental rotation task shown in adolescents with ADHD-CT is also evident in children with ADHD-CT. A crosssectional study of 12 pre-pubertal, right-handed, 8-12-year-old boys with ADHD-CT and 12 prepubertal, right-handed, performance IQ-matched, 8-12-year-old healthy boys, recruited from local primary schools, was completed. Participants underwent functional magnetic resonance imaging while performing a mental rotation task that requires spatial working memory. The two groups did not differ in their accuracy or response times for the mental rotation task. The ADHD-CT group showed significantly less activation in right parieto-occipital areas (cuneus and precuneus, BA 19), the right inferior parietal lobe (BA 40) and the right caudate nucleus. Our findings with a child cohort confirm previous reports of right striatal-parietal dysfunction in adolescents with ADHD-CT. This dysfunction suggests a widespread maturational deficit that may be developmental stage independent.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 82%

Right parietal dysfunction in children with attention deficit hyperactivity disorder, combined type: a functional MRI study

et al. 2007

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“…Also, the right hemispheric hypoarousal theory of ADHD has long suggested that inattention and impulsivity associated with ADHD is due to a lateralised disturbance in frontal lobe network function, mediated by the dysfunction of predominantly right hemispheric frontostriatal (Sheppard et al 1999) and frontoparietal tracts (Carter et al 1995). However, most prior studies lacked the statistical power to fractionate the ADHD phenotype further, and analyse the relationship between core symptoms of ADHD and these specific brain networks.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study

Sanefuji

Craig

Parlatini

et al. 2017

Cortex

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Two core symptoms characterize Attention Deficit Hyperactivity Disorder (ADHD) subtypes: inattentiveness and hyperactivity-impulsivity. While previous brain imaging research investigated ADHD as if it was a homogenous condition, its two core symptoms may originate from different brain mechanisms. We, therefore, hypothesized that the functional connectivity of cortico-striatal and attentional networks would be different between ADHD subtypes. We studied 165 children (mean age 10.93 years; age range, 7-17 year old) diagnosed as having ADHD based on their revised Conner's rating scale score and 170 typical developing individuals (mean age 11.46 years; age range, 7-17 year old) using resting state functional fMRI. Groups were matched for age, IQ and head motion during the MRI acquisition. We fractionated the ADHD group into predominantly inattentive, hyperactive-impulsive and combined subtypes based on their revised Conner's rating scale score. We then analyzed differences in resting state functional connectivity of the cortico-striatal and attentional networks between these subtypes. We found a double dissociation of functional connectivity in the cortico-striatal and ventral attentional networks, reflecting the subtypes of the ADHD participants. Particularly, the hyperactive-impulsive subtype was associated with increased connectivity in cortico-striatal network, whereas the inattentive subtype was associated with increased connectivity in the right ventral attention network. Our study demonstrated for the first time a right lateralized, double dissociation between specific networks associated with hyperactivity-impulsivity and inattentiveness in ADHD children, providing a biological M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 2 basis for exploring symptom dimensions and revealing potential targets for more personalized treatments.

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“…A number of studies have reported the presence of attentional asymmetries in ADHD using both clinical and experimental measures of attention (Voeller and Heilman, 1988;Carter et al, 1995;Nigg et al, 1997;McDonald et al, 1999;Sheppard et al, 1999). Failure to replicate these effects in some studies (Wood et al, 1999;Klimkeit et al, 2003), nevertheless, suggests neuropsychological heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

Association between Dopamine Transporter (DAT1) Genotype, Left-Sided Inattention, and an Enhanced Response to Methylphenidate in Attention-Deficit Hyperactivity Disorder

Bellgrove

Hawi

Kirley

et al. 2005

Neuropsychopharmacol

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A polymorphism of the dopamine transporter gene (DAT1, 10-repeat) is associated with attention-deficit hyperactivity disorder (ADHD) and has been linked to an enhanced response to methylphenidate (MPH). One aspect of the attention deficit in ADHD includes a subtle inattention to left space, resembling that seen after right cerebral hemisphere damage. Since left-sided inattention in ADHD may resolve when treated with MPH, we asked whether left-sided inattention in ADHD was related to DAT1 genotype and the therapeutic efficacy of MPH. A total of 43 ADHD children and their parents were genotyped for the DAT1 3 0 variable number of tandem repeats polymorphism. The children performed the Landmark Test, a well-validated measure yielding a spatial attentional asymmetry index (leftward to rightward attentional bias). Parents rated their child's response to MPH retrospectively using a three-point scale (no, mediocre or very good response). Additionally, parents used a symptom checklist to rate behavior while on and off medication. A within-family control design determined whether asymmetry indices predicted biased transmission of 10-repeat parental DAT1 alleles and/or response to MPH. It was found that left-sided inattention predicted transmission of the 10-repeat allele from parents to probands and was associated with the severity of ADHD symptomatology. Children rated as achieving a very good response to MPH displayed left-sided inattention, while those rated as achieving a poorer response did not. Our results suggest a subgroup of children with ADHD for whom the 10-repeat DAT1 allele is associated with left-sided inattention. MPH may be most efficacious in this group because it ameliorates a DAT1-mediated hypodopaminergic state.

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Asymmetrical visual-spatial attentional performance in ADHD: Evidence for a right hemispheric deficit

Cited by 120 publications

References 20 publications

Right parietal dysfunction in children with attention deficit hyperactivity disorder, combined type: a functional MRI study

Right parietal dysfunction in children with attention deficit hyperactivity disorder, combined type: a functional MRI study

Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study

Association between Dopamine Transporter (DAT1) Genotype, Left-Sided Inattention, and an Enhanced Response to Methylphenidate in Attention-Deficit Hyperactivity Disorder

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