Asymmetry and Vitalism

Japp, Francis R.

doi:10.1038/058616b0

Cited by 24 publications

(18 citation statements)

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“…So far, various possibilities have been proposed to explain the emergency of the initial chiral bias in biomolecules [101,[147][148][149]. However, these results are controversial [19,150].…”

Section: Discussionmentioning

confidence: 99%

Symmetry Breaking in Self-Assembled Nanoassemblies

Sang

Liu

2019

Symmetry

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The origin of biological homochirality, e.g., life selects the L-amino acids and D-sugar as molecular component, still remains a big mystery. It is suggested that mirror symmetry breaking plays an important role. Recent researches show that symmetry breaking can also occur at a supramolecular level, where the non-covalent bond was crucial. In these systems, equal or unequal amount of the enantiomeric nanoassemblies could be formed from achiral molecules. In this paper, we presented a brief overview regarding the symmetry breaking from dispersed system to gels, solids, and at interfaces. Then we discuss the rational manipulation of supramolecular chirality on how to induce and control the homochirality in the self-assembly system. Those physical control methods, such as Viedma ripening, hydrodynamic macro- and micro-vortex, superchiral light, and the combination of these technologies, are specifically discussed. It is hoped that the symmetry breaking at a supramolecular level could provide useful insights into the understanding of natural homochirality and further designing as well as controlling of functional chiral materials.

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Section: Discussionmentioning

confidence: 99%

Symmetry Breaking in Self-Assembled Nanoassemblies

Sang

Liu

2019

Symmetry

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“…The first mystery of homochirality is notified in organic molecules in life [6,7]. All amino acids in proteins are left-handed, and sugars in DNA and RNA are right-handed.…”

Section: Introductionmentioning

confidence: 99%

“…The phenomena have been attracting attentions due to a possible relevance with the origin of homochirality in life [6][7][8], and also due to potential application to pharmaceutics for enantiomeric purification.…”

Section: Introductionmentioning

confidence: 99%

Grinding-induced homochirality in crystal growth

Saitō

Hyuga

2011

Journal of Crystal Growth

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“…1,2) To understand the possible origin of this onehandedness or homochirality in life, Frank proposed a model rate equation with nonlinear reaction terms. 3) In a research field of organic chemistry, Soai and his group found, for the first time, a system which shows the amplification of enantiomeric excess (ee) in the production of chiral molecules from achiral substrates.…”

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confidence: 99%

Crystal Chirality Selected by Mutual Antagonism

Saitō

Hyuga

2010

J. Phys. Soc. Jpn.

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To explore the mechanism of chiral symmetry breaking in a process of crystal growth under grinding, we propose a simple irreversible growth model of a lattice-gas with four possible states on a site: occupied by an achiral molecule A, or by a chiral enantiomer R or S, or empty. After two A molecules on neighboring sites form a chiral dimer R 2 or S 2 , clusters grow by incorporating A's at cluster periphery, irreversibly. Only the grinding recycles products R or S back to A. It is then demonstrated in kinetic Monte Carlo (KMC) simulations that chirality selection takes place in the presence of the grinding. The cause for this realization is attributed to mutual antagonistic inhibition: that is, clusters of opposite enantiomeric types are brought into contact through stirring, and they block crystallization sites on cluster peripheries each other. The density evolution obtained by time integration of the rate equations with this antagonistic inhibition fits well with results of KMC simulations.

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Asymmetry and Vitalism

Cited by 24 publications

References 0 publications

Symmetry Breaking in Self-Assembled Nanoassemblies

Symmetry Breaking in Self-Assembled Nanoassemblies

Grinding-induced homochirality in crystal growth

Crystal Chirality Selected by Mutual Antagonism

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