2022
DOI: 10.1364/ol.455938
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Asymmetry robust centroid localization in confocal microscopy

Abstract: We present a centroid algorithm with asymmetry-robust error compensation for the peak position localization of asymmetrical axial response signals in confocal microscopy. Compared with the state-of-the-art algorithms, which are usually developed for symmetrical signals, our asymmetry robust centroid algorithm is found to have much smaller localization bias and higher precision for an asymmetrical confocal signal in numerical simulations and experiments.

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Cited by 5 publications
(2 citation statements)
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“…Therefore, these methods are robust and accurate, but complex and inefficient. The other algorithm is the centroid algorithm (CA), including the traditional centroid algorithm [16] and various improvements [17][18][19]. CA operates directly on the raw SPD data without fitting, offering significant efficiency.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, these methods are robust and accurate, but complex and inefficient. The other algorithm is the centroid algorithm (CA), including the traditional centroid algorithm [16] and various improvements [17][18][19]. CA operates directly on the raw SPD data without fitting, offering significant efficiency.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, signal filtering can lead to a loss of information. A further algorithm that handles asymmetrical depth response signals based on the centroid method is introduced by Chen et al (2022). However, this algorithm can be insufficient in determining the exact peak location and thus probably may lead to systematic deviations in height determination, for example, in the case of layer thickness measurements, where signals from different interfaces may be more or less asymmetric (see Section 3.4).…”
Section: Introductionmentioning
confidence: 99%