Asymptomatic fusiform aneurysm of the petrous carotid artery in a patient with von Recklinghausen's neurofibromatosis

Frank, Edmund; Brown, Ben Maurice; Wilson, David

doi:10.1016/0090-3019(89)90041-4

Cited by 43 publications

(15 citation statements)

References 15 publications

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“…15,19,46,47 An association between NF1 and intracranial aneurysms has also been suggested on the basis of a series of 23 case reports describing intracranial aneurysms in NF1 patients. 19,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] As a result of this proposed association, it has been suggested that patients with NF1 be screened for intracranial aneurysms. 33 In addition to NF1, other hereditary diseases have historically been associated with intracranial aneurysms.…”

Section: Discussionmentioning

confidence: 99%

“…The basis for this purported association is a series of 23 case reports describing intracranial aneurysms in NF1 patients. 19,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] The alleged increased prevalence of intracranial aneurysms in NF1 patients has led to the recommendation that NF1 patients should be screened for these lesions. 33 The purpose of the present study was to analyze our institution's clinical experience with NF1 patients and to review the literature for assessment of the perceived association between NF1 and intracranial aneurysms.…”

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confidence: 99%

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Lack of Evidence for an Association Between Neurofibromatosis Type I and Intracranial Aneurysms: Autopsy Study and Review of the Literature

Conway¹,

Hutchins²,

Tamargo³

2001

Stroke

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Background and Purpose-Neurofibromatosis type I (NF1) is an autosomal dominant, hereditary, neurocutaneous syndrome purported to be associated with intracranial aneurysms. To study the relationship between NF1 and intracranial aneurysms, we have analyzed all intracranial autopsies of NF1 patients performed at our institution from 1889 to 1999 and analyzed all intracranial aneurysm cases at our institution from 1990 to 1999 in an attempt to identify patients with NF1. In addition, we have reviewed published clinical series of NF1 patients. Methods-The autopsy database at our institution, which contains 50 000 cases from 1889 to 1999, was searched to identify NF1 patients, and the results of these autopsies were reviewed. The prevalence of intracranial aneurysms in these NF1 patients was compared with the prevalence of intracranial aneurysms in our hospital's autopsy population and with the published prevalence of intracranial aneurysms in the general population. To identify patients with intracranial aneurysms and NF1, our institution's intracranial aneurysm database was searched for patients with clinical manifestations of NF1. Published clinical series of NF1 patients were identified through searches of the literature. Results-None of the 25 autopsy patients with NF1 had an intracranial aneurysm. None of the 925 patients treated for intracranial aneurysms were affected by NF1. A review of the literature identified 8 comprehensive clinical studies, all of which failed to document any relationship between NF1 and intracranial aneurysms. Conclusions-The autopsy prevalence of no NF1 patients with intracranial aneurysms out of 25 is not different from the prevalence of intracranial aneurysms in the general autopsy population. In addition, no patients treated for intracranial aneurysms at this institution had NF1. These findings are supported by the observation that an association between NF1 and intracranial aneurysms has never been identified in 8 large clinical studies of NF1 patients. We conclude that there is a lack of evidence for any association between NF1 and intracranial aneurysms.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Lack of Evidence for an Association Between Neurofibromatosis Type I and Intracranial Aneurysms: Autopsy Study and Review of the Literature

Conway¹,

Hutchins²,

Tamargo³

2001

Stroke

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“…Unlike these other two heritable disorders, however, the association between NF1 and intracranial aneurysms has not been firmly established. Although numerous case reports and small series of patients with NF1 and intracranial aneurysms have been published [Bergouignan and Arne, 1951;Gibbons and Brookes, 1967;Momose and New, 1976;Leone et al, 1982;Debure et al, 1984;Chono et al, 1985;Kamiyama et al, 1985;Sobata et al, 1988;Frank et al, 1989;Gomori et al, 1991;Muhonen et al, 1991;Benatar, 1994;Poli et al, 1994;Uranishi et al, 1995;Schievink, 1997b;Oyama et al, 1998;Siqueira Neto et al, 1998;Zhao and Han, 1998;Sampei et al, 1999;Mitsui et al, 2001], recent reports have called this association into question and most large series of patients with NF1 do not note intracranial aneurysms as a manifestation of the disease [Conway et al, 2001]. The NFI Cardiovascular Task Force reviewed the literature and summarized that ''Intracranial aneurysms-may also occur in NFI patients but are less common (than intracranial arterial occlusive disease) and tend to be seen in older patients'' [Friedman et al, 2002].…”

Section: Introductionmentioning

confidence: 99%

Frequency of incidental intracranial aneurysms in neurofibromatosis type 1

2005

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Neurofibromatosis type 1 (NF1) is often mentioned among the heritable connective tissue disorders associated with intracranial aneurysms, but the association has not been firmly established. We therefore reviewed a contemporary series of hospitalized patients with NF1, many of whom underwent brain magnetic resonance imaging (MRI). We identified patients with NF1 who were hospitalized at Cedars-Sinai Medical Center, Los Angeles, California, between January 1, 1997 and December 31, 2001 through the hospital's centralized medical records system using DRG codes. The mean age of the 39 patients was 30.4 years, and 22 patients had undergone MRI of the brain for the evaluation of symptoms due to the presence of central or peripheral nervous system tumors. Incidental intracranial aneurysms were detected in 2 (5%) of the 39 patients. Limiting the patient population to the 22 patients who had undergone MRI examination, the detection rate was 9%. This was significantly (P < 0.005) higher than the aneurysm detection rate in a control population (0/526 [0%]) of patients hospitalized for primary or secondary brain tumors, all of whom had undergone MRI examination. Our study suggests that patients with NF1 are at an increased risk of developing intracranial aneurysms.

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“…Whereas renal artery stenosis with resultant hypertension is the most commonvascular abnormality in patients with NF1, intracranial arterial disease is relatively rare. Amongcerebral vascular disease, major arterial occlusion with moyamoyadisease (3) and intracranial arterial aneurysms have been reported (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Here we describe a case of NF1 manifesting lateral medullary infarction with fusiform aneurysm at the basilar artery.…”

Section: Introductionmentioning

confidence: 99%

Neurofibromatosis Type 1 with Basilar Artery Fusiform Aneurysm Manifesting Wallenberg's Syndrome.

et al. 2001

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A case of neurofibromatosis type 1 (NF1) manifesting Wallenberg's syndrome and fusiform aneurysm of the basilar artery is reported. The patient suddenly developed dysarthria, walking difficulty and sensory disturbance. Neurological examination suggested Wallenberg's syndrome and MRimaging confirmed an ischemic lesion at the left lateral medulla oblongata. Cerebral angiography revealed a fusiform aneurysm at the middle portion of the basilar artery. However, there was no occlusive change in either the posterior inferior cerebellar artery or the vertebral artery. The clinical and radiological features are discussed together with a review of NF1 cases with intracranial aneurysms in the literature. (Internal Medicine 40: 948-951, 2001)

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Asymptomatic fusiform aneurysm of the petrous carotid artery in a patient with von Recklinghausen's neurofibromatosis

Cited by 43 publications

References 15 publications

Lack of Evidence for an Association Between Neurofibromatosis Type I and Intracranial Aneurysms: Autopsy Study and Review of the Literature

Lack of Evidence for an Association Between Neurofibromatosis Type I and Intracranial Aneurysms: Autopsy Study and Review of the Literature

Frequency of incidental intracranial aneurysms in neurofibromatosis type 1

Neurofibromatosis Type 1 with Basilar Artery Fusiform Aneurysm Manifesting Wallenberg's Syndrome.

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