Asymptomatic Pyuria in Diabetic Women.

Abstract

The aim of the present study was to determine the prevalence of and the host factors for asymptomatic pyuria (ASP) in women with type 2 diabetes. The study included 179 type 2 diabetic women and consecutive 455 non-diabetic women attending as out-patients in 1996. Patients with symptoms of a urinary tract infection were excluded. ASP was defined as the presence of more than 10 leukocytes/high-power field in a random urine sample. Diabetic women more often had ASP than non-diabetic women (27.9 vs. 15.8%, P<0.001). The prevalence of ASP was significantly increased in patients with a duration of diabetes exceeding 15 years (0 approximately 4 years; 20.3%, 5 approximately 9 years; 24.3%, 10 approximately 14 years; 23.8%, and > or =15 years; 46.3%). No differences were evident in HbA(1C) between diabetic patients without ASP and those with ASP. Diabetic women with ASP more often had diabetic retinopathy, neuropathy, nephropathy, cerebrovascular disease, ischemic heart disease, and hyperlipidemia than those without ASP. However, no statistically significant differences were evident in the prevalence of hypertension, constipation, or dementia. As the degree of neuropathy increases, it is accompanied by an increasing prevalence of ASP (none, 21.4%; blunt tendon reflexes, 24.5%; symptomatic, 50.0%; and gangrene, 66.6%). The prevalence of ASP was significantly increased in the patients with proliferative diabetic retinopathy (none, 23.2%; background, 29.4%; pre-proliferative, 18.2%; and proliferative, 50.0%). As the degree of nephropathy increases, it is accompanied by an increasing prevalence of ASP (none, 20.0%; microalbuminuria, 31.9%; macroalbuminuria, 37.0%; and renal failure, 60.0%). Thus, the prevalence of ASP is increased in women with diabetes and increased with longer duration of diabetes but was not affected by glucose control. The incidence of ASP increases significantly as diabetic microangiopathy becomes severer.

Gauging the Risk Factors for Asymptomatic Bacteriuria in Type-2 Diabetic Women: A Case-Control Study

“…Next, we evaluated pyuria as a risk factor for ASBU. Pyuria is considered significant at more than 10 leukocytes per mm of urine [ 22 ]. Our study indicates no association between ASBU and pyuria.…”

“…Our study indicates no association between ASBU and pyuria. Only 14 cases had pyuria, and interestingly, 19 controls also reported pyuria [ 22 ]. The finding that pyuria is not significantly associated with ASBU implies the absence of inflammation in ASBU, which contrasts with symptomatic UTIs.…”

Correlation between Asymptomatic Leukocyturia and UrinaryN-Acetyl-β-d-glucosaminidase in Women

“…We have shown that the prevalence of asymptomatic leukocyturia (ASL) is higher in women with diabetes than in those without diabetes, and these diabetic complications, especially neuropathy, are factors contributing to the development of ASL in diabetic women. 4 In addition, we recently demonstrated a relationship between ASL and impairment of the parasympathetic nervous system in women. 5 On the other hand, N-acetyl-β-D-glucosaminidase (NAG) is a widely distributed lysosomal enzyme with a molecular weight of 130,000-140,000 Da, located predominantly in renal proximal tubules.…”