Asymptomatic reactivation of SARS-CoV-2 in a child with neuroblastoma characterised by whole genome sequencing

Yadav, Satya Prakash; Thakkar, Dhwanee; Bhoyar, Rahul C.; Jain, Abhinav; Wadhwa, Teena; Imran, Mohamed; Jolly, Bani; Divakar, Mohit Kumar; Kapoor, Rohit; Rastogi, Neha; Sharma, Disha; Sehgal, Paras; Ranjan, Gyan; Sivasubbu, Sridhar; Sarma, Satyam

doi:10.1016/j.idcr.2020.e01018

Cited by 9 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All the previous findings make more likely the alternative explanation, namely reactivation, for the high sequence similarities between the specimens collected during the 2 episodes experienced by case R. The subtle differences (2 different SNPs and 16 identical SNPs) found for this case are similar to those described in a reactivation reported elsewhere [ 11 ]. The reactivation hypothesis implies that SARS-CoV-2 had remained undetected (or unsampled) in a reservoir between the 2 sequential episodes.…”

Section: Discussionsupporting

confidence: 80%

See 1 more Smart Citation

Proper Assignation of Reactivation in a COVID-19 Recurrence Initially Interpreted as a Reinfection

Pérez‐Lago

Martínez-Lozano

Díaz

et al. 2021

The Journal of Infectious Diseases

View full text Add to dashboard Cite

A 77-year-old-male (Case R) who had had a previous diagnosis of mild COVID-19 episode, was hospitalized 35 days later. On Day 23 post-admission, he developed a second COVID-19 episode, now severe, and finally died. Initially, Case R COVID-19 recurrence was interpreted as a reinfection due to the exposure to a SARS-CoV-2 RT-PCR-positive room-mate. However, whole-genome-sequencing indicated that case R recurrence corresponded to a reactivation of the strain involved in his first episode. Case R reactivation had major consequences, leading to a more severe episode, and causing a subsequent transmission to another two hospitalized patients, one of them with fatal outcome.

show abstract

Section: Discussionsupporting

confidence: 80%

“…Few studies have proposed reactivation as the explanation for COVID-19 recurrence [ 5 , 15 ], some involving immunosuppression. However, only 2 were supported with viral genome analyses [ 11 ] (D.A. Molina, unpublished).…”

Section: Discussionmentioning

confidence: 99%

Proper Assignation of Reactivation in a COVID-19 Recurrence Initially Interpreted as a Reinfection

Pérez‐Lago

Martínez-Lozano

Díaz

et al. 2021

The Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…In case reports and case series, a total of 276 cases between the age of three [ 27 ] and 93 [ 28 ] years were recorded as re-positive by PCR. About 101 cases had one or more comorbidities.…”

Section: Resultsmentioning

confidence: 99%

“…The duration between the two infection episodes varied between one [ 29 – 33 ] and 32 weeks [ 34 ]. Applying the Robert Koch Institute’s (RKI) definition for probability of reinfection [ 35 ], 217 non-previously confirmed reinfection cases were classified as possible reinfection and eight case as probable reinfection [ 27 , 36 – 41 ] as shown in S2 Table . Thirty-eight cases were not classified as either possible, probable or confirmed reinfections as not all case definition elements were reported as required by RKI criteria.…”

Section: Resultsmentioning

confidence: 99%

Recurrent SARS-CoV-2 infections and their potential risk to public health – a systematic review

et al. 2021

View full text Add to dashboard Cite

Objective To inform quarantine and contact-tracing policies concerning re-positive cases—cases testing positive among those recovered. Materials and methods We systematically reviewed and appraised relevant literature from PubMed and Embase for the extent of re-positive cases and their epidemiological characteristics. Results In 90 case reports/series, a total of 276 re-positive cases were found. Among confirmed reinfections, 50% occurred within 90 days from recovery. Four reports related onward transmission. In thirty-five observational studies, rate of re-positives ranged from zero to 50% with no onward transmissions reported. In eight reviews, pooled recurrence rate ranged from 12% to 17.7%. Probability of re-positive increased with several factors. Conclusion Recurrence of a positive SARS-CoV-2 test is commonly reported within the first weeks following recovery from a first infection.

show abstract

“…Genomic viral analysis has been applied to determine within-host SARS-CoV-2 evolution in patients with persistent infection ( 6 , 7 ) but has not been used in the same way to analyze coronavirus disease (COVID-19) recurrences involving the same strain. The scant available reports focus primarily on clinical descriptions ( 8 , 9 ), only some of which are supported by detailed genomic analysis ( 10 ).…”

mentioning

confidence: 99%

Systematic Genomic and Clinical Analysis of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfections and Recurrences Involving the Same Strain

Rodríguez‐Grande¹,

Alcalá²,

Estévez³

et al. 2022

Emerg. Infect. Dis.

View full text Add to dashboard Cite

Estimates of the burden of severe acute respiratory syndrome coronavirus 2 reinfections are limited by the scarcity of population-level studies incorporating genomic support. We conducted a systematic study of reinfections in Madrid, Spain, supported by genomic viral analysis and host genetic analysis, to cleanse laboratory errors and to discriminate between reinfections and recurrences involving the same strain. Among the 41,195 cases diagnosed (March 2020–March 2021), 93 (0.23%) had 2 positive reverse transcription PCR tests (55–346 days apart). After eliminating cases with specimens not stored, of suboptimal sequence quality, or belonging to different persons, we obtained valid data from 22 cases. Of those, 4 (0.01%) cases were recurrences involving the same strain; case-patients were 39–93 years of age, and 3 were immunosuppressed. Eighteen (0.04%) cases were reinfections; patients were 19–84 years of age, and most had no relevant clinical history. The second episode was more severe in 8 cases.

show abstract

Asymptomatic reactivation of SARS-CoV-2 in a child with neuroblastoma characterised by whole genome sequencing

Cited by 9 publications

References 12 publications

Proper Assignation of Reactivation in a COVID-19 Recurrence Initially Interpreted as a Reinfection

Proper Assignation of Reactivation in a COVID-19 Recurrence Initially Interpreted as a Reinfection

Recurrent SARS-CoV-2 infections and their potential risk to public health – a systematic review

Systematic Genomic and Clinical Analysis of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfections and Recurrences Involving the Same Strain

Contact Info

Product

Resources

About