A high-speed four-state continuous-variable quantum key distribution (CV-QKD) system, enabled by wavelength-division multiplexing, polarization multiplexing, and orbital angular momentum (OAM) multiplexing, is studied in the presence of atmospheric turbulence. The atmospheric turbulence channel is emulated by two spatial light modulators (SLMs) on which two randomly generated azimuthal phase patterns yielding Andrews' spectrum are recorded. The phase noise is mitigated by the phase noise cancellation (PNC) stage, and channel transmittance can be monitored directly by the D.C. level in our PNC stage. After the system calibration, a total SKR of >1.68 Gbit/s can be reached in the ideal system, featured with lossless channel and free of excess noise. In our experiment, based on commercial photodetectors, the minimum transmittances of 0.21 and 0.29 are required for OAM states of 2 (or −2) and 6 (or −6), respectively, to guarantee the secure transmission, while a total SKR of 120 Mbit/s can be obtained in case of mean transmittances.