Asystolic cardiac arrest following liposomal amphotericin B infusion: anaphylaxis or compliment activation-related pseudoallergy?

Drewett, George; Copaescu, Ana; Holmes, Natasha E; Trubiano, Jason A

doi:10.1186/s13223-021-00582-x

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…Some of these adverse reactions are associated with an infusion-related reaction but the differential diagnosis of anaphylaxis needs to be considered, as reported in the literature [56][57][58] -Table 1. IgE-mediated reactions are rarely associated with amphotericin B [59]. Liposomal formulations of amphotericin B have been associated with complement activation-related pseudoallergy (CARPA) [60].…”

Section: Polyene Antimycotic Macrolidesmentioning

confidence: 99%

Antifungal hypersensitivity reactions and cross-reactivity patterns

Copaescu

Phillips

Trubiano

2021

Current Opinion in Infectious Diseases

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Purpose of reviewThe goal of this article is to provide an updated understanding and evidence-based approach where possible for antifungal hypersensitivity. This includes recognition of clinical phenotype, implications for cross-reactivity and diagnostic, and management strategy for immediate and delayed hypersensitivity reactions. Recent findingsAntifungal hypersensitivity reactions can be classified according to their latency (immediate or delayed) and clinical phenotype. The majority of the cases described in the literature are delayed T-cell mediated reactions of various severities but immediate reactions consistent with non-Immunoglobulin E (IgE)-mediated mast cell activation and IgE-mediated reactions have also been described. Ancillary information such as skin testing, drug challenge and ex vivo experimental approaches can aid causality assessments and inform antifungal class cross-reactivity, which help optimize antifungal prescribing and stewardship.

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