At-birth immunisation against hepatitis B using a novel pre-filled immunisation device stored outside the cold chain

Prevalence of chronic hepatitis B virus infection after implementation of a hepatitis B vaccination program among children in three provinces in Cambodia

“…In other countries with a high number of unattended home births, successful strategies, such as the use of simple injection devices (e.g. Uniject) and the use of the vaccine in a controlledtemperature chain have been implemented to reach these infants [23][24][25][26].…”

Coverage of and Influences on Timely Administration of Hepatitis B Vaccine Birth Dose in Remote Rural Areas of the People’s Republic of China

“…22,23 Birth dosing of infants delivered at home is apparently logistically and/or administratively difficult or otherwise unacceptable. 3 One solution to this problem has been addressed by several reports in recent years, including an overview of HepB vaccination in China 7 and one overview 24 and several field studies (in Indonesia, 25,26 Vietnam, 27 and Guangxi 28 ), of storage of vials of HepB at ambient temperature in local clinics or maternity units, with a view to increasing access to HepB 1 in areas lacking refrigeration. Each study indicated that storing HepB 1 outside the cold chain may improve timely HepB 1 in remote, rural areas where there is no cold chain, but an overview of Indonesia's experience cast doubt on uptake of this strategy 23 and it is not yet permitted by regulatory authorities in China or Vietnam.…”

Economic benefits of keeping vaccines at ambient temperature during mass vaccination: the case of meningitis A vaccine in Chad

“…Second, CTCs may allow the thermostability of a vaccine to be exploited fully and make it possible for vaccinators to extend their reach to areas and populations that are so remote that they could never be reached by a cold chain system -while avoiding the vaccine damage caused by inadvertent freezing. [18][19][20] If the requirement for a cold chain can be reduced, it may also be possible to use vaccination activities as a better delivery platform for other maternal and child health interventions. 21 Third, the use of a CTC for a relatively thermostable vaccine could free up valuable space in cold storage for other vaccines that have poorer thermostability.…”