AT2R −1332 G:A polymorphism and its interaction with AT1R 1166 A:C, ACE I/D and MMP-9 −1562 C:T polymorphisms: Risk factors for susceptibility to preeclampsia

Rahimi, Zohreh; Rahimi, Ziba; Aghaei, Amir; Vaisi‐Raygani, Asad

doi:10.1016/j.gene.2013.12.013

Cited by 43 publications

(42 citation statements)

References 26 publications

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“…Additionally, several studies have reported an association between MMP-9 genetic polymorphism and the development of pre-eclampsia; however, the results of these studies are inconclusive (Coolman et al, 2007;Fraser et al, 2008;Palei et al, 2010Palei et al, , 2012Luizon et al, 2012;Rahimi et al, 2013Rahimi et al, , 2014Rahimi et al, , 2015. Some studies suggested that the CC genotype or C allele of MMP-9 -1562 C/T is associated with increased risk of developing pre-eclampsia in Caucasian pregnant women (Coolman et al, 2007;Luizon et al, 2012;Rahimi et al, 2013Rahimi et al, , 2014Rahimi et al, , 2015.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies suggested that the CC genotype or C allele of MMP-9 -1562 C/T is associated with increased risk of developing pre-eclampsia in Caucasian pregnant women (Coolman et al, 2007;Luizon et al, 2012;Rahimi et al, 2013Rahimi et al, , 2014Rahimi et al, , 2015. However, Fraser et al (2008) suggested that MMP-9 -1562 C/T genetic polymorphism failed to present any significant association with pre-eclampsia.…”

Section: Discussionmentioning

confidence: 99%

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Investigation of the association between matrix metalloproteinase-9 genetic polymorphisms and development of pre-eclampsia in Chinese pregnant women

Sun

Zhang

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We carried out a case-control study to evaluate the role of MMP-9 -1562 C/T (rs3918242) genetic polymorphism in the risk of pre-eclampsia in Chinese pregnant women. Between March 2013 and January 2015, 107 pregnant women with pre-eclampsia were recruited from the Second Affiliated Hospital of Zhengzhou University. Genotyping of MMP-9 was carried out using polymerase chain reactionrestriction fragment length polymorphism assay. Unconditional logistic regression analyses revealed that women with the CT genotype (OR = 1.81, 95%CI = 1.04-3.11) exhibited significantly higher risk of preeclampsia than those with the wild-type CC genotype. Moreover, individuals carrying the T allele were at higher risk of pre-eclampsia than those carrying the C allele; the adjusted OR (95%CI) was 1.62 2 C. Sun et al. Genetics and Molecular Research 15 (3): gmr.15038355 (1.06-2.47). In conclusion, our study demonstrated that the MMP-9 -1562 C/T polymorphism plays an important role in the development of pre-eclampsia in Chinese women. Further studies with large sample sizes are greatly needed to confirm our findings.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Investigation of the association between matrix metalloproteinase-9 genetic polymorphisms and development of pre-eclampsia in Chinese pregnant women

Sun

Zhang

et al. 2016

Genet. Mol. Res.

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“…Several mechanisms are involved in the regulation of MMP activity, including transcription activation, and function inhibition by TIMPs (11). The MMPs polymorphism is associated with susceptibility to diseases such as multiple sclerosis, rheumatoid arthritis cancer and preeclampsia (12,13). There are no available reports about the influence of MMP-7 A-181 G polymorphism on the risk of RR-MS disease.…”

Section: Introductionmentioning

confidence: 99%

The Association Between Matrix Metalloproteinase-7 A-181G Polymorphism and the Risk of Relapsing-Remitting Multiple Sclerosis in Iranian Kurdish Patients from Kermanshah

Mohammadi¹,

Rahimi²,

Rahimi³

2015

Avicenna J Med Biochem

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Background: Multiple sclerosis (MS) is a common chronic genetic disease of the central nervous system. The relapsing-remitting-MS (RR-MS) is the most common form of this disease. Matrix metalloproteinase-7 (MMP-7) is an important member of the MMP family, which degrades many extracellular matrix components. The common polymorphism of MMP-7 A-181G is associated with some diseases. Objectives: The aim of the present study was to determine the influence of this polymorphism on the risk of RR-MS. Materials and Methods: Eighty RR-MS patients and 80 healthy individuals as controls from the Kermanshah province were studied for MMP-7 A-181G polymorphism by using the PCR-RFLP method. Data were analyzed using the SPSS statistical software package version 16.0. Results: In RR-MS patients the frequency of MMP-7 GG genotype was significantly (P = 0.028) higher compared to that of the controls. The presence of GG genotype increased the risk of RR-MS by 1.69 times [OR = 1.69 and 95% CI = 1.05-2.72, P = 0.03]. The frequency of MMP-7 G allele in RR-MS patients was significantly higher (51.2%, P = 0.043) than that of the controls (40%). The presence of this allele increased the risk of RR-MS by 1.58 folds (P = 0.044). Conclusions: Our findings indicate that the presence of G allele of MMP-7 A-181G polymorphism might increase the risk of RR-MS in our population.

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“…It led to the most significant discrepancy (DD vs II, homozygote model) and the relative risk was estimated at 1.81 (CI: 1.29-2.66; p = 0.003). ACE D allele was also associated with preeclampsia (in a recent study [126] ). Overall, the subject of a genetic basis for recurrent pregnancy loss has been strongly associated with thrombophilic disorders, with major scientific contributions.…”

Section: Thrombophilic Disordersmentioning

confidence: 88%

Genetic regulation of recurrent spontaneous abortion in humans

Vaiman¹

2015

Biomed J

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Recurrent pregnancy loss, defined as a pregnancy failure occurring before 24 weeks of gestation more than two or three times according to most definitions, is a fertility defect encountered in 1-5% of the patients. This defect is of course of multifactorial origin. Among the possible origins of recurrent pregnancy loss are uterine structural defaults, defective ploidy control of the embryo, defective immunological dialog between the embryo (or the fetus) and the uterus sometimes in relation with immunological disorders (such as autoimmune diseases), thrombophilia, and free radical metabolism imbalance. Numerous studies attempted to correlate variants of genes supposed to be intervening in the different facets of the early maternal-fetal or maternal-embryonic dialog, and eventually modify the outcome of fertilization, leading to success or failure of post-implantation development. The objective of the present review is to portray the major genes and gene polymorphisms studied for their putative association with recurrent pregnancy loss. Most of these genes have been studied as candidate genes for which strong biological arguments were put forward as to their putative involvement in recurrent pregnancy loss. They were mostly studied by genetic analysis, often in various populations of different ethnic origins, throughout the world. Some of these studies were available only in English as abstracts and were nevertheless used if the information was given with enough detail. With the space being too short to depict all the available literature, different major pathways releva nt to the scientific question are presented without any attempt to hide the fact that discordant views often aroused for a given gene. rather attempt to categorize the factors that were analyzed according to their biological functions and summarize their putative effects.

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AT2R −1332 G:A polymorphism and its interaction with AT1R 1166 A:C, ACE I/D and MMP-9 −1562 C:T polymorphisms: Risk factors for susceptibility to preeclampsia

Cited by 43 publications

References 26 publications

Investigation of the association between matrix metalloproteinase-9 genetic polymorphisms and development of pre-eclampsia in Chinese pregnant women

Investigation of the association between matrix metalloproteinase-9 genetic polymorphisms and development of pre-eclampsia in Chinese pregnant women

The Association Between Matrix Metalloproteinase-7 A-181G Polymorphism and the Risk of Relapsing-Remitting Multiple Sclerosis in Iranian Kurdish Patients from Kermanshah

Genetic regulation of recurrent spontaneous abortion in humans

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