Ataxia as a presenting manifestation of COVID -19: Report of a single case

Abstract

Even though various neurological presentations of COVID-19 have surfaced up, ataxia as a presenting feature has rarely been reported so far. We hereby describe a confirmed case of SARS-CoV-2 infection which not only presented with ataxia but also had delayed onset of typical respiratory features. This case represents an atypical manifestation of COVID-19.

SARS-CoV-2 Encephalitis Presenting as a Clinical Cerebellar Syndrome

“…Cerebellar ataxia in patients with COVID-19 is increasingly described, but SARS-CoV-2 has rarely been detected in CSF of previous cases tested, potentially reflecting sample collection timing or different pathogenic mechanisms. [3][4][5] Although initial examination suggested pancerebellar dysfunction, imaging abnormalities were confined to the brainstem. Several reports have similarly shown clinicalradiologic disconnect in patients with COVID-19 with cerebellar signs, with MRI showing no abnormalities, or abnormalities located exclusively outside the cerebellum.…”

Acute Post‐Infectious Cerebellar Ataxia Due to COVID‐19

“…Currently, there are four previous reports of isolated cerebellar ataxia manifesting in adults following COVID-19 infection. [5][6][7][8] In addition to these, Abdel-Mannan et al, described 27 children with COVID-19 associated with MIS-C. In this group, four had new-onset neurological symptoms, one of whom developed cerebellar ataxia.…”

“…APCA in children develops a few days to weeks following viral illness but may follow bacterial infections and vaccinations. Currently, there are four previous reports of isolated cerebellar ataxia manifesting in adults following COVID‐19 infection 5–8 . In addition to these, Abdel‐Mannan et al, described 27 children with COVID‐19 associated with MIS‐C.…”

A novel multi-omics-based identification of symptoms, comorbid conditions, and possible long-term complications in COVID-19

“…In this analysis too, the viral infection is ranked one. The common comorbid conditions such as autoimmune disease (Rank-2) [50], vascular disease (Rank-4) [71], kidney disease (Rank-5) [56, 57], neurodegenerative disease (Rank-6) [72], bone inflammation disease (Rank-7) [73], myocardial disorder (Rank-7) [74], mood disorder (Rank-7) [34], breast cancer (Rank-10) [75], liver disease (Rank-10) [58], gynaecologic cancers (Rank-11) [76], asthma (Rank-12) [77], liver cancer (Rank-13) [78], musculoskeletal abnormality (Rank-14) [63], hematologic cancer (Rank-15) [79], retinal degeneration (Rank-15) [80], sepsis / septicaemia / septic shock (Rank-15) [60, 81], diabetes (Rank-16) [82], other cardiovascular diseases (Rank-17) [71, 74], viral encephalitis (Rank-17) [83], other cognitive disorder (Rank-18) [24], immunodeficiency (Rank-19) [84], brain disease (Rank-19) [85], COPD (Rank-19) [86], gastric / colon cancer (Rank-20) [87], autism (Rank-21) [88, 89], anemia (Rank-21) [90], bone development and degenerative disease (Rank-20) [91], dyslipidaemia (Rank-22) [92, 93], and ataxia (Rank-23) [94] etc. are among the top 25 child disease categories at a cut off score of 4 ( Fig-2B ).…”

“…In this analysis too, the viral infection is ranked one. The common comorbid conditions such as autoimmune disease (Rank-2) [50], vascular disease (Rank-4) [71], kidney disease (Rank-5) [56,57] [92,93], and ataxia (Rank-23) [94] etc. are among the top 25 child disease categories at a cut off score of 4 (Fig-2B).…”