Ataxic vs painful form of paraneoplastic neuropathy

Abstract

Paraneoplastic neuropathy can be characterized into two groups by the presence of sensory ataxia or severe spontaneous pain and severe mechanical hyperalgesia. Preferential small myelinated and unmyelinated fiber loss correlated to the cases of severe pain.

Differential, size-dependent sensory neuron involvement in the painful and ataxic forms of primary Sjögren's syndrome-associated neuropathy

“…In paraneoplastic sensory neuropathy, CD8+ cytotoxic T cells are situated around the DRG and often indent the capsule of satellite cells to come in close attachment with DRG [42,43]. Therefore, CD8+ T cellmediated cytotoxicity plays an important role in the pathogenesis of paraneoplastic sensory neuropathy, although onconeural antibodies, especially anti-Hu antibodies, are frequently found in this form of neuropathy [45]. In this context, the mechanism of neuronal damage in both the painful and ataxic forms of pSS-associated neuropathy and paraneoplastic sensory neuropathy may share a similar process at the level of the ganglion.…”

Electrophysiological features of late-onset transthyretin Met30 familial amyloid polyneuropathy unrelated to endemic foci

“…Semithin sections were stained with toluidine blue for morphometric assessment with light microscopy. The density of myelinated fibers was assessed in toluidine blue-stained semithin sections using a computer-assisted image analyzer (Luzex FS; Nikon, Tokyo, Japan), and the densities of small and large myelinated fibers were calculated as described previously [25,27,32]. For electron microscopy, epoxy resin-embedded specimens were cut into ultrathin transverse sections and stained with uranyl acetate and lead citrate.…”

Demyelinating Neuropathy and Autoimmune Hemolytic Anemia in a Patient with Pancreatic Cancer

“…Among these conditions, paraneoplastic neurological syndromes exhibit a wide range of features that affect various areas of the nervous system (2). The representative forms of paraneoplastic neurological syndrome include encephalomyelitis, limbic encephalitis, subacute cerebellar degeneration and sensory neuronopathy (2)(3)(4). Although several types of paraneoplastic neurological syndromes may occur simultaneously or at different time points in a single patient (2,(4)(5)(6)(7), the combination of involvement of the nervous system and extraneural organs in a paraneoplastic setting has not been well documented.…”

“…Although sensory neuronopathy is the most common form of paraneoplastic neuropathy (2)(3)(4)8), features compatible with CIDP may arise as a form of paraneoplastic neurological syndrome (4). In contrast, AIHA is a well-known paraneoplastic phenomenon that occurs in patients with lymphoproliferative disorders, and there are a number of case reports of the association between AIHA and solid tumors (9).…”