Atenolol and Sustained Release Nifedipine Alone and in Combination in Hypertension

Anderton, J. L.; Vallance, B D; Stanley, N. N.; Crowe, Peter F.; Mittra, B; Perks, W.H.

doi:10.2165/00003495-198800354-00006

Cited by 16 publications

(3 citation statements)

References 3 publications

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“…Short‐ and long‐term trials, conducted predominantly in Caucasian subjects, indicate that atenolol given once a day is effective in reducing mild‐to‐moderate arterial hypertension and relieving the symptoms of angina pectoris (9). In comparative studies, its antihypertensive efficacy has been similar to that of other agents including slow‐release calcium channel blockers (including dihydropyridines) (10), diuretics (11) and ACE inhibitors (12–14). Atenolol was chosen as an appropriate comparative agent for telmisartan and is representative of beta‐blocker antihypertensives due to its wide use and once‐daily dosing.…”

Section: Introductionmentioning

confidence: 95%

Clinical efficacy and safety of telmisartan 80 mg once daily vs. atenolol 50 mg once daily in patients with mild-to-moderate hypertension

Alcocer

Fernández-Bonetti

Campos

et al. 2004

International Journal of Clinical Practice

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The objective of this open-label, parallel-group comparative study was to assess the clinical efficacy and safety of once-daily treatment for 8 weeks with telmisartan 80 mg in comparison with atenolol 50 mg on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with mild-to-moderate hypertension (morning supine SBP 141-199 mmHg, DBP 95-114 mmHg). A total of 58 patients were enrolled. The comparability of the two treatment groups was statistically documented at the beginning of the study. Telmisartan was more effective than atenolol, with a decrease in SBP of 21.7 mmHg vs. 11.8 mmHg (p ¼ 0.03) and a non-significant decrease in DBP of 14.7 mmHg vs. 10.1 mmHg. The safety profiles of both drugs were very similar; both drugs were well tolerated. In conclusion, once-daily telmisartan 80 mg is more effective than once-daily atenolol 50 mg in lowering SBP with no negative chronotropism. Furthermore, telmisartan was as well tolerated as atenolol in the treatment of mild-to-moderate essential hypertension in adults.

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Section: Introductionmentioning

confidence: 95%

Clinical efficacy and safety of telmisartan 80 mg once daily vs. atenolol 50 mg once daily in patients with mild-to-moderate hypertension

Alcocer

Fernández-Bonetti

Campos

et al. 2004

International Journal of Clinical Practice

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“…Consequently, greater reductions in blood pressure can be achieved by concomitant use of nifedipine and atenolol than either drug alone. This beneficial pharmacodynamic interaction has also been reported to result in fewer vasodilator‐related side effects (flushing, headache) when lower dosages of the two drugs are used in combination 7,8 .…”

Section: Introductionmentioning

confidence: 91%

“…We decided to examine the tolerability and efficacy of a fixed combination of a beta 1 ‐selective adrenergic blocker and a dihydropyridine calcium antagonist administered as a single capsule once daily to a group of elderly patients greater than 65 years of age. This combination of atenolol 50 mg and nifedipine retard 20 mg (Nif‐Ten) has been shown to be efficacious and well tolerated in hypertensive patients 7,9,10 .…”

Section: Introductionmentioning

confidence: 99%

Hypertension in the elderly: a study of a combination of atenolol and nifedipine

Duckett

Cheadle

1990

Int J Clinical Practice

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SummaryThe antihypertensive effects and tolerability of a once‐daily, fixed combination of atenolol 50 mg and nifedipine retard 20 mg ('Nif‐Ten'®) were monitored in a 12‐month open study in 30 elderly hypertensive patients, whose blood pressure was inadequately controlled after four weeks treatment with atenolol 50 mg once daily.Sitting (and standing) blood pressure and heart rate one to four hours after dosing were recorded at entry (191/95 mmHg) and at the end of the run‐in period (186/93 mmHg). After one month's therapy with the fixed combination the mean sitting blood pressure fell to 169/89 mm Hg and was maintained at this level for the entire 12‐month period of observation.During the study four patients complained of side effects on fixed combination therapy with one patient withdrawn due to flushes and hot sweats. One other patient suffered flushes and hot sweats and two patients complained of mild dizziness. There were no demonstrable effects of fixed combination therapy upon the biochemical parameters measured.We conclude that the fixed combination of atenolol plus nifedipine retard was well tolerated over a 12‐month period in the group of elderly hypertensive patients studied. The combination appears to exert a greater antihypertensive effect than the beta‐blocker monotherapy with no evidence of tachyphylaxis, although these findings require confirmation in a controlled trial.

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Blood pressure lowering efficacy of beta-blockers as second-line therapy for primary hypertension

Chen

Heran

Perez

et al. 2010

Cochrane Database of Systematic Reviews

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Addition of a beta-blocker to diuretics or calcium-channel blockers reduces BP by 6/4mmHg at 1 times the starting dose and by 8/6 mmHg at 2 times the starting dose. When the blood pressure lowering effect of beta-blockers from this review was compared to that of thiazide diuretics from our previous review (Chen 2009), second-line beta-blockers reduce systolic BP to the same extent as second-line thiazide diuretics, but reduce diastolic BP to a greater degree. The different effect on diastolic BP means that beta-blockers have little or no effect on pulse pressure whereas thiazides cause a significant dose-related decrease in pulse pressure. This difference in the pattern of BP lowering with beta-blockers as compared to thiazides might be the explanation for the fact that beta-blockers appear to be less effective at reducing adverse cardiovascular outcomes than thiazide diuretics, particularly in older individuals.

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Atenolol and Sustained Release Nifedipine Alone and in Combination in Hypertension

Cited by 16 publications

References 3 publications

Clinical efficacy and safety of telmisartan 80 mg once daily vs. atenolol 50 mg once daily in patients with mild-to-moderate hypertension

Clinical efficacy and safety of telmisartan 80 mg once daily vs. atenolol 50 mg once daily in patients with mild-to-moderate hypertension

Hypertension in the elderly: a study of a combination of atenolol and nifedipine

Blood pressure lowering efficacy of beta-blockers as second-line therapy for primary hypertension

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