Atenolol in essential hypertension during pregnancy

Butters, L; Kennedy, Sara; Rubin, Peter C.

doi:10.1016/0020-7292(91)90335-3

Cited by 19 publications

(25 citation statements)

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“…Ten of the trials were conducted in a predefined chronic hypertension cohort alone, and the remaining 5 reported outcomes for a subgroup of women with chronic hypertension . Six studies were head‐to‐head comparisons of 2 or more antihypertensive agents (435 women), 4 were placebo‐controlled studies of a single antihypertensive agent (219 women), and 5 were studies of a single antihypertensive agent compared to no treatment (714 women) …”

Section: Resultsmentioning

confidence: 99%

Impact of Antihypertensive Treatment on Maternal and Perinatal Outcomes in Pregnancy Complicated by Chronic Hypertension: A Systematic Review and Meta‐Analysis

Webster

Conti‐Ramsden

Seed

et al. 2017

JAHA

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BackgroundChronic hypertension complicates around 3% of all pregnancies. There is evidence that treating severe hypertension reduces maternal morbidity. This study aimed to systematically review randomized controlled trials of antihypertensive agents treating chronic hypertension in pregnancy to determine the effect of this intervention.Methods and ResultsMedline (via OVID), Embase (via OVID) and the Cochrane Trials Register were searched from their earliest entries until November 30, 2016. All randomized controlled trials evaluating antihypertensive treatments for chronic hypertension in pregnancy were included. Data were extracted and analyzed in Stata (version 14.1). Fifteen randomized controlled trials (1166 women) were identified for meta‐analysis. A clinically important reduction in the incidence of severe hypertension was seen with antihypertensive treatment versus no antihypertensive treatment/placebo (5 studies, 446 women; risk ratio 0.33, 95%CI 0.19‐0.56; I2 0.0%). There was no difference in the incidence of superimposed pre‐eclampsia (7 studies, 727 women; risk ratio 0.74, 95%CI 0.49‐1.11; I2 28.1%), stillbirth/neonatal death (4 studies, 667 women; risk ratio 0.37, 95%CI 0.11‐1.26; I2 0.0%), birth weight (7 studies, 802 women; weighted mean difference −60 g, 95%CI −200 to 80 g; I2 0.0%), or small for gestational age (4 studies, 369 women; risk ratio 1.01, 95%CI 0.53‐1.94; I2 0.0%) with antihypertensive treatment versus no treatment/placebo.ConclusionsAntihypertensive treatment reduces the risk of severe hypertension in pregnant women with chronic hypertension. A considerable paucity of data exists to guide choice of antihypertensive agent. Adequately powered head‐to‐head randomized controlled trials of commonly used antihypertensive agents are required to inform prescribing.

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Section: Resultsmentioning

confidence: 99%

Impact of Antihypertensive Treatment on Maternal and Perinatal Outcomes in Pregnancy Complicated by Chronic Hypertension: A Systematic Review and Meta‐Analysis

Webster

Conti‐Ramsden

Seed

et al. 2017

JAHA

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“…Although this drug has been shown to cross the placenta28, 78, it has been used successfully in pregnancy. The safety of beta‐blockers in pregnancy is more controversial, as a causative link with intrauterine growth retardation has been suggested79. However, short‐term use is accepted to control tachycardia after alpha‐blockade has been established.…”

Section: Discussionmentioning

confidence: 99%

Systematic review of phaeochromocytoma in pregnancy

Biggar

Lennard

2013

Journal of British Surgery

107

102

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“…11 In fact, the blunting of progression to more severe hypertension is the only consistent benefit seen in the clinical trials of drug treatment of chronic hypertension in pregnancy. A small, prospective, randomized, double-blind, placebo-controlled trial 12 and a retrospective study, 12 however, showed significantly reduced birth weights using atenolol. Other β-blockers such as metoprolol, labetalol, pindolol, and oxyprenalol 11,13,14 prevent progression of hypertension without fetal growth retardation.…”

Section: What Drugs Are Safe To Treat Chronic Hypertension In a Pregnmentioning

confidence: 99%

Managing Chronic Severe Hypertension in Pregnancy

Handler

2006

J of Clinical Hypertension

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Atenolol in essential hypertension during pregnancy

Cited by 19 publications

References 0 publications

Impact of Antihypertensive Treatment on Maternal and Perinatal Outcomes in Pregnancy Complicated by Chronic Hypertension: A Systematic Review and Meta‐Analysis

Impact of Antihypertensive Treatment on Maternal and Perinatal Outcomes in Pregnancy Complicated by Chronic Hypertension: A Systematic Review and Meta‐Analysis

Systematic review of phaeochromocytoma in pregnancy

Managing Chronic Severe Hypertension in Pregnancy

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