Atherogenic dyslipidemia in patients with established coronary artery disease

Lahoz, Carlos; Mostaza, J.M.; Tranche, Salvador; Martín-Jadraque, Raquel; Mantilla, María Teresa; López-Rodríguez, Isidro; Monteiro, Beatriz P.; Sánchez-Zamorano, Miguel A.; Taboada, Manuel

doi:10.1016/j.numecd.2010.04.010

Cited by 21 publications

(8 citation statements)

References 20 publications

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“…Cigarette smoking came at the last (47.33%). Our results agreed with some other studies [17][18][19] . Saito et al, 20 found that the prevalence of hypertension was 45.8%, diabetes mellitus was 15.8% while cigarette smoking was 16.7% which differs regarding the prevalence from our study.…”

Section: Discussionsupporting

confidence: 94%

Pattern and Prevalence of Dyslipidemia among Patients with Acute Coronary Syndrome Admitted in a Tertiary Level Hospital

Parvin¹,

Baul²,

Hossain³

et al. 2019

Bangladesh Heart J

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Background: The leading cause of mortality in men and women worldwide is coronary artery disease (CAD). For hospitalization in our country, acute coronary syndrome (ACS) is a major reason. Dyslipidemia is found one of the most important modifiable risk factors for CAD. Aim: The aim of the study was to determine the pattern and prevalence of dyslipidemia among patients with ACS admitted in National Institute of Cardiovascular Diseases (NICVD), Dhaka. Subjects and methods: One thousand (1000) patients with ACS were included and classified according to clinical presentation, the findings on the admission electrocardiogram (ECG) and the results of serial cardiac troponin levels, into myocardial infarction(MI), either STelevation or non ST- elevation MI, and unstable angina(UA) subgroups. In the other group 500 healthy subjects were included as controls. All subjects were subjected determination lipid profile. ECG and Troponin- I were done for diagnosis and follow up of the patients. Results: In patients with ACS, high levels of TC (>200 mg/dl) were found in 60.67%,high levels of LDL (> 130 mg/dl) were found in 58%, high levels of TG (>150 mg/ dl) were found in 63.33%, however, low levels of HDL (< 40 mg/dl) were found in 66%. There was a statistically significant elevation in TC, LDL, TG serum levels in patients with ACS compared to control subjects (p<0.05) while the HDL was significantly low in ACS patient compared to control subjects (p <0.05). TC/HDL > 5 and TG/HDL> 4 were significantly higher in patients with ACS than controls. There was no significant difference between MI and UA patients regarding all lipid profile parameters. TC, LDL, TG were significantly higher in males than in females while HDL was significantly higher in females compared to males. Also TC/HDL and TG/HDL ratios were significantly higher in males compared to females. All lipid components were significantly more prevalent in males than in females except TG where there was no significant difference between males and females. Stepwise regression analysis of lipid parameters revealed that TC/HDL and TG/HDL ratios were independent risk factors for ACS. Conclusion: Dyslipidemia is one the major risk factors which is widely prevalent in patients with ACS and is more prevalent in males than in females. We recommend paying more attention to serum lipids and other modifiable risk factors for prevention of ACS and more studies about them as risk factors of atherosclerosis and its impact on other systems is advised. Bangladesh Heart Journal 2019; 34(1) : 31-36

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Section: Discussionsupporting

confidence: 94%

Pattern and Prevalence of Dyslipidemia among Patients with Acute Coronary Syndrome Admitted in a Tertiary Level Hospital

Parvin¹,

Baul²,

Hossain³

et al. 2019

Bangladesh Heart J

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“…Our results agreed with Sandhu et al, Lahoz et al, and Cooke et al, (2006). [13,14,15] And we found significant association between the hypertension, T2DM and disease distribution while there was no any association between smoking. Saito et al, [16] found that the prevalence of hypertension was 45.8%, diabetes mellitus was 15.8% while cigarette smoking was 16.7% which differs regarding the prevalence from our study.…”

Section: Discussionmentioning

confidence: 51%

Lipid Levels in Acute Coronary Syndromes Admitted in Medical Intensive Care Unit in a Tertiary Care Hospital

Patange¹,

Immadisetty²,

Vora³

et al. 2020

jemds

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BACKGROUND Coronary artery disease (CAD) is the leading cause of mortality in men and women. Acute coronary syndrome (ACS), is a major reason for hospitalisation in our country. Dyslipidemia has been identified as one of the most important modifiable risk factors for CAD. The aim of the study was to determine the prevalence and pattern of dyslipidaemia and its relation to other modifiable risk factors. METHODS 100 cases were studied in a Krishna Institutes of Medical Sciences, Karad, over a period of 12 months from 1 st August 2015 to 31 st July 2016. This is a prospective observational study. All adults >18 years of age admitted for acute coronary syndrome were eligible for this study. The ACS group was studied as STEMI, NSTEMI, and Unstable Angina. RESULTS Majority of patients (33) was in the age group 51-60 years followed by 29 patients in the age group 61-70 years. Out of 100 ACS patients, 62 were STEMI, 20 were NSTEMI, and 18 were unstable angina. The prevalence of ACS was higher in males than females. Hypertension is the most common risk factor of ACS (41%) followed by diabetes mellitus (33%). We found that high levels of TC (more than 200 mg/dl) were found in 31% patients [mean ± SD (167.79 mg/dl ± 45.28)]. High levels of LDL (more than 130 mg/dl) were found in 23% patients [mean ± SD (97.47 mg/dl ± 38.24)]. Low levels of HDL (less than 40 mg/dl) were found in 52% patients [mean ± SD (40.69 mg/dl ± 11.84)]. High levels of TG (more than 150 mg/dl) were found in 37 % patients [mean ± SD (145.28 mg/dl ± 65.78)]. CONCLUSIONS Dyslipidemia is one of the major risk factors which is widely prevalent in patients with ACS and is more prevalent in males than in females. We recommend paying more attention to serum lipids and other modifiable risk factors for prevention of ACS

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“…Atherogenic dyslipidemia (AD) was present in 35.77% patients which is lower than its prevalence (41.3%) observed in a study conducted at Pune and is higher than that in another study (13%). 16 Majority of these patients belonged to the age group of 51-60 years (43.2%) which is in contrast to the study conducted at Pune which concluded that AD had no association with age.…”

Section: Lipid Profile Patterns and Atp III Risk Assessmentcontrasting

confidence: 58%

Linking of different ethnicities, races and religions to lipid profile patterns and hypolipidaemic drug usage patterns in coronary artery disease patients

Bharadwaj¹,

Patel

Rana

et al. 2019

Int J Basic Clin Pharmacol

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Modifiable risk factors like hypercholesterolaemia, hypertension, smoking, obesity, diabetes mellitus and sedentary lifestyle provide opportunities for individuals and populations to reduce their likelihood of developing CAD. Lipid profile, a screening tool for lipid abnormalities, typically includes Low-density lipoprotein (LDL), High-density lipoprotein (HDL), triglycerides ABSTRACT Background: Coronary artery disease (CAD) is the consequence of atherosclerosis in which inadequate blood flow in the coronary arteries leads to myocardial necrosis. The impact of ethnic on CAD might be underestimated within Indian communities. There have never been any studies done associating them to lipid profile patterns in the Indian setup hence this study is the first of its kind to work towards attending the absence of data in this direction.The study aimed to evaluate the presence of ethnic differences in lipid profile patterns and hypolipidemic drug use in CAD patients. Methods: An 8-week cross-sectional prospective study was conducted in the cardiology OPD of a tertiary care hospital. Adult CAD patients prescribed with at least one hypolipidaemic drug, having their lipid profile values and willing to give informed consent were selected. The prescription pattern was noted, and the lipid profile values of the patients classified as per ATP III guidelines by NCEP. Atherogenic dyslipidaemia was considered when patients had triglyceride levels >150 mg/dl and HDL<40 mg/dl. The collected data was analyzed using SPSS. P value less than 0.05 was considered as statistically significant. Results: A total of 123 patients enrolled. Out of these, 115 were Hindus and among Hindus, most were Brahmins (34). The most prescribed hypolipidaemic drug was Rosuvastatin. Thirty six patients had high triglyceride levels out of which 35 were Hindus. Low HDL (<40 mg/dl) was present in 70 patients out of which 64 were Hindus. Atherogenic dyslipidaemia was seen in 44 patients. Majority of them belonged to the age group of 51-60 years (43.2%) and were Patels. Total cholesterol and LDL were high in 1 and 2 Jains respectively. Lipid values were higher in Tier-3 city patients. Conclusion: Hindu patients in this study showed a poorer lipid profile while among the castes, Jains and Patel's fared poorly. It was seen that atherogenic dyslipidemia is on a rise in the Indian population.

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Atherogenic dyslipidemia in patients with established coronary artery disease

Cited by 21 publications

References 20 publications

Pattern and Prevalence of Dyslipidemia among Patients with Acute Coronary Syndrome Admitted in a Tertiary Level Hospital

Pattern and Prevalence of Dyslipidemia among Patients with Acute Coronary Syndrome Admitted in a Tertiary Level Hospital

Lipid Levels in Acute Coronary Syndromes Admitted in Medical Intensive Care Unit in a Tertiary Care Hospital

Linking of different ethnicities, races and religions to lipid profile patterns and hypolipidaemic drug usage patterns in coronary artery disease patients

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