2016
DOI: 10.1111/febs.13634
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Atherosclerosis and aortic aneurysm – is inflammation a common denominator?

Abstract: Cardiovascular diseases (CVD) are the major cause of death in developed countries. Various risk factors including host genetics and, more importantly, environmental factors such as lifestyle, diet and smoking influence CVD progression. Two common forms of CVD are atherosclerosis and abdominal aortic aneurysm (AAA). Emerging evidence suggests that inflammation plays a pivotal role in CVD. However, it remains unclear whether the same inflammatory pathways prove essential for atherosclerosis and AAA because, in s… Show more

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Cited by 112 publications
(100 citation statements)
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References 135 publications
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“…Aortic aneurysms occur secondary to pathologic remodeling of the aortic wall and are frequently associated with hypertension [2], atherosclerosis [3,4] in the abdominal aorta, and bicuspid aortopathy [5], or connective tissue disorders [6] in the ascending thoracic aorta. The pathogenesis of aneurysms differs based on the involved aortic segment.…”
Section: Introductionmentioning
confidence: 99%
“…Aortic aneurysms occur secondary to pathologic remodeling of the aortic wall and are frequently associated with hypertension [2], atherosclerosis [3,4] in the abdominal aorta, and bicuspid aortopathy [5], or connective tissue disorders [6] in the ascending thoracic aorta. The pathogenesis of aneurysms differs based on the involved aortic segment.…”
Section: Introductionmentioning
confidence: 99%
“…Several cytokines have been implicated in the regulation of immune cells in AAA site 3,29,49,50,51,52,53,54,55 ; however, the possible contribution of cytokine signaling in controlling of AAAdriven "stress induced" HSCs expansion and differentiation toward myeloid lineages has never been reported. Here, we for the first time establish IL-27R signaling as a critical regulator of Ang II-driven proliferation and differentiation of HSC, essential for Ang II-induced stress myelopoiesis in a non-infectious, chronic vascular injury model.…”
Section: Discussionmentioning
confidence: 99%
“…Inactivation of IL-27R exacerbates atherosclerosis 26,27,28 and leads to the development of abdominal aortic lesions which typically are rare in atherosclerotic mice. As atherosclerosis and AAA may share some underlying chronic inflammatory mechanisms 29 , we anticipated that IL-27R-deficiency would increase inflammation and promote AAA.…”
Section: Il-27r Signaling Promotes Ang Ii-induced Abdominal Aortic Anmentioning
confidence: 99%
“…Due to the fact that the same factors participate in the atherosclerotic plaque formation, it is difficult to state whether the above observations represent a true association with AAAs or if they simply reflect the higher incidence of atherosclerotic disease found in this group of patients. Both diseases affect arteries, share predisposing risk factors, and exhibit similar immune and inflammatory cell infiltrates [57]. Moreover, one of the hypotheses assumes that AAA develops as a pathological response to aortic atherosclerosis [24].…”
Section: Discussionmentioning
confidence: 99%