Atherosclerosis Specific Features in Chronic Kidney Disease (CKD)

Poznyak, Anastasia V.; Sadykhov, Nikolay K.; Kartuesov, Andrey G.; Borisov, Evgeny E.; Sukhorukov, Vasily N.; Orekhov, Alexander N.

doi:10.3390/biomedicines10092094

Cited by 19 publications

(14 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both calcification and fibrosis result in reduced vascular compliance and hemodynamic disturbance [61][62][63]. CVD risk factors such as inflammation, oxidative stress, endothelial dysfunction, uremic toxins, and disturbances in lipid and glucose metabolism play a significant role in the development of atherosclerosis and arteriosclerosis [59,63]. The correlations observed in our study after KT suggest that inflammation and lipid profile should be indeed regulated irrespective of the reduction in mt-cfDNA.…”

Section: Discussionmentioning

confidence: 67%

“…ESKF patients, as models of EVA [10,21], may have coexisting atherosclerosis and arteriosclerosis [59,60]. Both calcification and fibrosis result in reduced vascular compliance and hemodynamic disturbance [61][62][63]. CVD risk factors such as inflammation, oxidative stress, endothelial dysfunction, uremic toxins, and disturbances in lipid and glucose metabolism play a significant role in the development of atherosclerosis and arteriosclerosis [59,63].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Levels of Cell-Free DNA in Kidney Failure Patients before and after Renal Transplantation

Leotta,

Hernandez,

Tothova

et al. 2023

Cells

View full text Add to dashboard Cite

Circulating cell-free DNA (cfDNA) has diverse applications in oncological, prenatal, toxicological, cardiovascular, and autoimmune diseases, diagnostics, and organ transplantation. In particular, mitochondrial cfDNA (mt-cfDNA) is associated with inflammation and linked to early vascular ageing (EVA) in end-stage kidney failure (ESKF), which could be a noninvasive marker for graft rejection and organ damage. Plasma samples from 44 ESKF patients, of whom half (n = 22) underwent either conservative therapy (non-HD) or hemodialysis (HD) before kidney transplantation (KT). These samples were analyzed at baseline and two years after KT. cfDNA was extracted from plasma and quantified using the fluorometric method. qPCR was used to quantify and differentiate the fractions of mt-cfDNA and nuclear cfDNA (nc-cfDNA). mt-cfDNA levels in KT patients decreased significantly from baseline to two years post-KT (p < 0.0268), while levels of total cfDNA and nc-cfDNA did not differ. Depending on therapy modality (HD vs. non-HD) before KT, total cfDNA levels were higher in HD patients at both baseline (p = 0.0133) and two years post-KT (p = 0.0421), while nc-cfDNA levels were higher in HD only at baseline (p = 0.0079). Males showed a nonsignificant trend of higher cfDNA levels. Patients with assessed vascular fibrosis (p = 0.0068), either alone or in combination with calcification plus fibrosis, showed reduced mt-cfDNA post-KT (p = 0.0195). Changes in mt-cfDNA levels suggests the impact of KT on the inflammatory state of ESKF, as evidenced via its correlation with high sensitivity C-reactive protein after KT. Further studies are warranted to assess if cfDNA could serve as a noninvasive method for monitoring the response to organ transplantation and even for amelioration of EVA status per se.

show abstract

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Levels of Cell-Free DNA in Kidney Failure Patients before and after Renal Transplantation

Leotta,

Hernandez,

Tothova

et al. 2023

Cells

View full text Add to dashboard Cite

show abstract

“…Additional research noted a link between carotid artery distensibility coe cient or arterial wall stiffness, as assessed via B-mode ultrasound, and thoracic aorta 29 calci cation 29 . As elaborated upon, chronic kidney disease accelerates the atherosclerotic process through myriad mechanisms, encompassing oxidative stress, endothelial dysfunction, in ammation, toxic 30 e uents, and albuminuria 30 . These pathophysiological pathways contribute to systemic arterial calci cation, culminating in atherosclerosis across critical arterial systems, including coronary, carotid, intracranial, and peripheral 31 arteries 31 .…”

Section: Discussionmentioning

confidence: 99%

Geometric Changes and Clinical Risk Factors from Aortic Arch to Proximal Internal Carotid Artery between Normal Subjects and Moderate Right Carotid Plaques

Ngo,

Lee,

Kwak

2024

Preprint

View full text Add to dashboard Cite

Objective The anatomical features spanning from the aortic arch to the proximal carotid artery and the associated cardiovascular risks might significantly influence the development of right carotid plaque. Our research aimed to compare these anatomical and risk factors between individuals with no carotid plaque and those with moderate right-side carotid plaque within a Korean cohort. Methods We conducted a retrospective, cross-sectional analysis involving 413 participants, categorized into a normal group (n = 339) and a right moderate carotid plaque group (defined as > 50% stenosis based on NASCET criteria)(n = 74). We collected data on cardiovascular risk factors and conducted laboratory tests. A 3D model of the carotid artery was constructed using cranio-cervical computed tomography angiography (CTA) data through semi-automated software. Measurements taken on this 3D model included the common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA), and carotid artery bifurcation (CAB) in terms of maximal vascular diameter, sectional area, angles of carotid bifurcation and ICA, and carotid tortuosity. Results When compared with the normal group, individuals in the right moderate carotid plaque group exhibited smaller angles at the carotid bifurcation, larger CCA diameter and sectional area (p < 0.01), advanced age, and a higher incidence of hypertension, diabetes, and stroke history (p < 0.05), along with reduced glomerular filtration rate (GFR) (p < 0.001). Multivariate analysis revealed that the sectional area of the bifurcation, calcification of the aortic bulb, and GFR were independently associated with the presence of right moderate carotid plaque (p < 0.01). Conclusions Statistical analyses disclosed significant differences in both clinical risk factors and geometric changes in the region extending from the aortic arch to the proximal carotid artery among subjects with right moderate carotid plaque when compared to those without.

show abstract

“…In addition to common atherosclerotic risk factors such as age, hypertension, DM, dyslipidemia, and smoking, other CKD-related atherosclerotic risk factors, including endothelial dysfunction, oxidative stress, inflammation, abnormal lipid modifications, uremic toxins, mineral bone metabolism, and vascular calcification, have also been identified [ 34 ]. Therefore, CKD is characterized by an increased atherosclerotic burden from early stages, and CKD patients are more prone to coagulation disorders and cardiovascular problems than the general population [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of acute ischemic stroke in patients with Nephrotic syndrome

Huang,

Chang,

Chen

et al. 2023

Renal Failure

View full text Add to dashboard Cite

The incidence of ischemic stroke (IS) is higher in nephrotic syndrome (NS) patients compared to general population. However, there is limited information on the specific characteristics to stroke patients with NS. In this study, we aimed to examine the clinical manifestations of acute IS in a large group of NS patients, comparing to those without NS. We conducted a retrospective cohort study to compare the clinical presentations of acute IS in patients with and without NS. This study was a multi-institutional study and used data from Chang Gung Research Database of Taiwan from 1 January 2001, to 31 December 2017. A total of 233 IS patients with NS and 1358 IS patients without NS were enrolled. The median age of participants was 68 (range: 59–79) years. The risk of dependent functional status (modified Rankin Scale score≧3) after IS was higher in NS patients compared to those without NS (Odd ratio (OR) 4.02, 95% confidence interval (CI) 2.39 to 6.76, p < 0.001), particularly in stroke subtypes as small-artery occlusion (OR 8.02, 95% CI 3.94 to 16.32, p < 0.001), and stroke of undetermined etiology (OR 2.47, CI 1.06 to 5.76, p = 037). The risks of mortality or stroke recurrence within 30 days were similar between the two groups for all stroke subtypes. In conclusion, NS was associated with a higher risk of functional dependence following IS. Intensive treatment and rehabilitation should be considered for IS patients with NS.

show abstract

Atherosclerosis Specific Features in Chronic Kidney Disease (CKD)

Cited by 19 publications

References 93 publications

Levels of Cell-Free DNA in Kidney Failure Patients before and after Renal Transplantation

Levels of Cell-Free DNA in Kidney Failure Patients before and after Renal Transplantation

Geometric Changes and Clinical Risk Factors from Aortic Arch to Proximal Internal Carotid Artery between Normal Subjects and Moderate Right Carotid Plaques

Characteristics of acute ischemic stroke in patients with Nephrotic syndrome

Contact Info

Product

Resources

About