2020
DOI: 10.1093/ehjcr/ytaa133
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Atherosclerotic spontaneous coronary artery dissection (A-SCAD) in a patient with COVID-19: case report and possible mechanisms

Abstract: Background Spontaneous coronary artery dissection (SCAD) may be atherosclerotic (A-SCAD) or non-atherosclerotic (NA-SCAD) in origin. Contemporary usage of the term ‘SCAD’ is typically synonymous with NA-SCAD. COVID-19 could induce a vascular inflammation localized in the coronary adventitia and periadventitial fat and contribute to the development of an A-SCAD of a vulnerable plaque in a susceptible patient. Case summary In t… Show more

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Cited by 17 publications
(16 citation statements)
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“…Albiero et al [57] published a case report on a 70-year-old man, treated three years before by percutaneous coronary intervention (PCI) and affected by COVID-19, who presented with ACS and non-ST segment elevation myocardial infarction (NSTEMI). The coronary angiogram showed atherosclerotic spontaneous coronary artery dissection (A-SCAD) on the proximal left anterior descending (LAD) coronary artery and in-stent restenosis of a marginal branch (OM).…”
Section: Effects Of Sars-cov-2 On Cardiovascular Systemmentioning
confidence: 99%
“…Albiero et al [57] published a case report on a 70-year-old man, treated three years before by percutaneous coronary intervention (PCI) and affected by COVID-19, who presented with ACS and non-ST segment elevation myocardial infarction (NSTEMI). The coronary angiogram showed atherosclerotic spontaneous coronary artery dissection (A-SCAD) on the proximal left anterior descending (LAD) coronary artery and in-stent restenosis of a marginal branch (OM).…”
Section: Effects Of Sars-cov-2 On Cardiovascular Systemmentioning
confidence: 99%
“…Most patients also had symptoms related to SARS-CoV-2 infection such as fever, dyspnea, and cough, which are not characteristic of acute coronary events. Of note is the fact that most patients with SCAD (n = 9) experienced mild symptoms related to COVID-19 [ 26 , 29 , 30 , 32 , 33 , 34 , 35 , 36 , 37 ], five of them faced more severe manifestations [ 28 , 31 , 38 , 39 , 40 ], and only two demonstrated no symptoms [ 41 , 42 ].…”
Section: Resultsmentioning
confidence: 99%
“…Specifically, eight out of twelve patients were diagnosed with non-ST-segment-elevation myocardial infarction (NSTEMI) [ 28 , 31 , 32 , 34 , 35 , 36 , 39 , 42 ], while the other seven patients had ST-elevation myocardial infarction (STEMI) [ 26 , 29 , 33 , 37 , 38 , 40 , 41 ]. In the majority of patients (10 out of the 12 cases), the vessel involved was the left anterior descending coronary artery [ 28 , 31 , 33 , 34 , 35 , 37 , 38 , 40 , 41 , 42 ]; the right coronary artery was affected in two patients [ 29 , 32 ], the circumflex in four patients [ 30 , 36 , 38 , 40 ], and the ramus intermedius in one patient [ 31 ]. Among these, two patients had multivessel dissection [ 26 , 38 ].…”
Section: Resultsmentioning
confidence: 99%
“…Cervical artery dissections [4] , [12] and spontaneous coronary artery and aortic dissections [13] , [14] have been reported in patients diagnosed recently with COVID-19, which suggests that COVID-19 may be a trigger factor for CVD . Clinical features such as younger age and lack of any known stroke risk factors may suggest that the strokes detected in patients with a history of COVID-19 may be caused by attributable to SARS-CoV-2 [7] .…”
Section: Discussionmentioning
confidence: 99%