Atividade antibacteriana do extrato hidroalcoólico de Punica granatum Linn. sobre Staphylococcus spp. isolados de leite bovino

Moreira, Giovanna Melatti Bermal; Matsumoto, Leopoldo Sussumu; Silva, Regildo M.G.; Domingues, Paulo Francisco; Mello-Peixoto, Erika Cosendey Toledo de

doi:10.1590/s0100-736x2014000700003

Cited by 15 publications

(12 citation statements)

References 33 publications

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“…These data are not in agreement with those of a previous in vitro study by Periera et al . [11] which showed that a bacterial strain present in supragingival plaque, namely, Streptococcus sanguis , was sensitive to different concentrations of the pomegranate extract, which demonstrated an inhibitory action similar to that of chlorhexidine. It should be highlighted, however, that in vitro studies do not reproduce exactly the oral conditions.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a herbal extract gel in the treatment of gingivitis: A clinical study

Somu¹,

Ravindra²,

Ajith³

et al. 2012

J Ayurveda Integr Med

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Background:Chronic gingivitis is the most prevalent in all dentate animals. Regular methods for controlling it have been found to be ineffective, which have paved the way for the use of herbal products as an adjunctive to mechanical therapy as they are free to untoward effects and hence can be used for a long period of time.Objective:The antigingivitis effect of a gel containing pomegranate extract was evaluated using a 21-day trial in patients with chronic gingivitis.Materials and Methods:Forty patients participated in this randomized clinical study, carried out in four phases of 7 days each over 21 days. The patients were randomly assigned to four groups: First group was treated with mechanical debridement and an experimental gel and the second group with mechanical debridement and a control gel; the third group wasn’t subjected to mechanical debridement and only experimental gel was used. The fourth group was treated with control gel only. All the groups were subjected to various clinical and microbiological parameters to evaluate the antiplaque and antigingivitis effect of the pomegranate extract.Results:The group which used the pomegranate gel along with mechanical debridement showed significant improvement in all the clinical and microbiological parameters included in the study when compared with the other three groups.Conclusion:Hence it can be concluded that the pomegranate gel when used as an adjunct with mechanical debridement was efficient in treating gingivitis.

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Section: Discussionmentioning

confidence: 99%

Efficacy of a herbal extract gel in the treatment of gingivitis: A clinical study

Somu¹,

Ravindra²,

Ajith³

et al. 2012

J Ayurveda Integr Med

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“…Plant-derived flavonoids, such as those extracted from mulberry ( Morus alba ) leaves, have also shown health-promoting properties due to the alteration of the expression and activity of key enzymes in lipid and carbohydrate metabolism 22, 23 , induction of protective effects against hydroxyl and superoxide radical damage 24 , antimicrobial activity 25, 26 , antiparasitic activity 27 , and antioxidant activity 24, 28 , among others. Previous studies have shown that flavonoids isolated from the leaves of many different plants exhibit antimicrobial activity against Gram-negative and Gram-positive bacteria and fungi in in vitro antimicrobial assays 29–34 .…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary supplementation with two alternatives to antibiotics on intestinal microbiota of preweaned calves challenged with Escherichia coli K99

Yang

Diao

et al. 2017

Sci Rep

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The aim of this study was to investigate the effects of dietary supplementation with two alternatives to antibiotics (Candida tropicalis and mulberry leaf flavonoids) on intestinal microbiota of preweaned calves challenged with Escherichia coli K99. Sixty Holstein calves were randomly assigned to 5 treatments: fed a basal diet (N-CON); fed a basal diet and challenged with E.coli K99 (P-CON); fed a basal diet supplemented with C.tropicalis (CT), mulberry leaf flavonoids (MLF), and the combination of the two additives (CM), respectively, and challenged with E.coli K99. The MLF and CM groups had significantly higher average daily grain and feed efficiency, and significantly lower fecal scores compared with the P-CON group after E. coli K99 challenge. The supplementation groups increased the relative abundance, at the phylum level, of Bacteroidetes and Proteobacteria, whereas at the genus level, they increased the relative abundance of Prevotella, Lactobacillus, and Enterococcus. Quantitative PCR revealed that the CT, MLF, and CM groups had significantly lower copy numbers of E.coli K99 compared with the P-CON group. The CT, MLF, and CM treatments reduce days of diarrhea, improve intestinal health, and beneficially manipulate the intestinal microbiota in preweaned calves.

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“…Regarding the dosage of 250 μg mL -1 , only the MIC test was able to demonstrate antimicrobial activity (Table 1, 2). Santos et al (2014) also examined the inhibitory effects of pomegranate peel extract on S. aureus isolates from cases of bovine mastites, which has also been checked by us in preliminary studies (Moreira et al, 2014). However, for the conditions evaluated by the present study, antimicrobial activity for Gram-negative bacteria was not observed.…”

Section: Resultsmentioning

confidence: 75%

“…Its constituents are alkaloids (peletierin, isopeletierin, metilpeletierin), tannins, phenolic compounds (anthocyanins, quercetin, phenolic acid) and flavonoids (Duman et al, 2009;Moorthy et al, 2013;Silva et al, 2013). Antimicrobial properties have been demonstrated (Moorthy et al, 2013), on S. aureus (Silva et al, 2013;Moorthy et al, 2013;Santos et al, 2014;Moreira et al, 2014). Antibacterial properties are particularly important for the treatment of bovine mastites.…”

Section: Introductionmentioning

confidence: 99%

In vitro antibacterial activities of pomegranate extract against standard microorganisms of bovine mastitis

Moreira¹,

Matsumoto²,

Silva³

et al. 2015

J. Med. Plants Res.

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Bovine mastitis is characterized by inflammation of the mammary gland, usually due to bacterial infection, compromising quantity and quality of milk production. This study aimed to determine the antibacterial activity, in vitro, of the hydroalcoholic extract of the pomegranate peel at 10% against standard strains of bovine mastitis. The colonies were adjusted to the concentration of 10 7 mL -1 using UV-visible spectrophotometry, and the extracts were evaluated in quintuplicate in concentrations of 1000, 500, 250, 75, 50 and 25 μg mL -1 . The sensitivity of the strains was determined using the minimum inhibitory concentration and disk diffusion test. Additionally, antioxidant activity and total phenolic content was evaluated. The extract, at concentrations of 500 and 1000 μg mL . Perhaps the presence of other substances in the extract may have been responsible for the antioxidant activity detected. That way, the antioxidant and antibacterial activities of EHPG 10% may represent an important therapeutic potential, particularly for animal health in organic and agroecological production systems.

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Atividade antibacteriana do extrato hidroalcoólico de Punica granatum Linn. sobre Staphylococcus spp. isolados de leite bovino

Cited by 15 publications

References 33 publications

Efficacy of a herbal extract gel in the treatment of gingivitis: A clinical study

Efficacy of a herbal extract gel in the treatment of gingivitis: A clinical study

Effects of dietary supplementation with two alternatives to antibiotics on intestinal microbiota of preweaned calves challenged with Escherichia coli K99

In vitro antibacterial activities of pomegranate extract against standard microorganisms of bovine mastitis

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