Atividade Antimicrobiana De Extratos De Raízes De Byrsonima Crassifolia

Gellen, Luís Fernando Albarello; Silva, Edgard Henrique Costa

doi:10.18067/jbfs.v3i2.88

Cited by 11 publications

(3 citation statements)

References 6 publications

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“…Its fruits and leaves are used to treat gastrointestinal problems, such as ulcers and diarrhea. Its roots are used to heal wounds and infections of the mouth and throat such as gingivitis, tonsillitis, and pharyngitis (Gellen and Silva 2016). An alcoholic fermented drink from B. crassifolia was obtained with physicochemical characteristics in accordance with the Brazilian legislation for grape wines, except for NaCl chlorides, ashes, and total titratable acidity parameters (Bizinoto 2017).…”

Section: Other Species With Technological Potentialmentioning

confidence: 99%

Food Composition Data: Edible Plants in Cerrado

et al. 2021

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181negative correlation between the in vitro potential of many molecules and their ADME/T (absorption, distribution, metabolism, excretion/toxicity) profile is generally noted (Gleeson et al. 2011). Synthetic compounds present a significantly lower number of chiral centers and are both smaller and present greater flexibility, which results in weaker, less specific activity (Feher and Schmidt 2003). In contrast, plantderived natural products present a diversity of bioactive compounds with differing chemical scaffolds (Atanasov et al. 2015). Plant-derived products possess properties, such as binding affinities for specific proteins, that are evolutionary optimized (Appendino et al. 2010;Hunter 2008). Such characteristics make plant-derived products more advantageous for conducting ADME/T tests (Atanasov et al. 2015). Another advantage in drug discovery using medicinal plants is the known good correlation between ethnopharmacological information (well documented) and the medical use of the plant. Around 80% of identified compounds present some ethnomedicinal use, whether identical or related to current usage of the active plant elements (Fabricant and Farnsworth 2001). Further, technological advances in systems biology, bioinformatics, plant specialized metabolism, and synthetic biology present opportunities through which the medicinal properties of plants are discovered, utilized, and expanded toward developing new herb-inspired medicines (Li and Weng 2017). Accordingly, plant-derived natural products still represent a valuable source for drug discovery, this, motivated by global public health challenges, such as COVID-19, HIV/AIDS, malaria, hypertension, diabetes, and cancer (Thomford et al. 2018). About a quarter of all Food and Drug Administration (FDA)-and/or European Medical Agency (EMA)-approved drugs are plant-derived (Patridge et al. 2016;Thomford et al. 2018).In this context, Brazil possesses various biomes with a great portion of the world's biodiversity and approximately 20% of the plants and microorganisms on the planet (Calixto 2000). Among these biomes, the Cerrado is a neotropical savanna with rich flora (Klink and Machado 2005). Over 13,127 highly endemic plant species have been recorded within this biome (Myers et al. 2000;Overbeck et al. 2015;Silva and Bates 2002;Silveira et al. 2016). Yet, in regard to environmental conservation, only 41% of the original Cerrado still remains as native vegetation (Soares-Filho et al. 2014). This reduction is due to anthropogenic activities, such as monoculture, pasture expansions, mineral extraction, and the growth of urban areas (Faleiro et al. 2013). Considering only agricultural activity between 2002 and 2009, an estimated loss of 92,712 km 2 of natural Cerrado area has occurred (Overbeck et al. 2015). Preservation policies in Brazil need improvement, yet only 7% of the Cerrado is under legal protection (Soares-Filho et al. 2014).Both the bio-prospecting potential of the Cerrado for medicinal species and knowledge concerning traditional medicines are disappear...

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Section: Other Species With Technological Potentialmentioning

confidence: 99%

Food Composition Data: Edible Plants in Cerrado

et al. 2021

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“…A grande importância da utilização das plantas na medicina, está relacionada com os bioativos que a planta sintetiza durante seu processo de crescimento, defesa contra patógenos ou produtos mediante a stress do ambiente como clima e escassez de água (Santana, et al, 2012;Gellen & Silva, 2016).…”

Section: Introductionunclassified

Atividade antimicrobiana de fitoconstituintes obtidos do caule de Solanum lycocarpum St. Hill

Gellen

Ferreira

Barros

et al. 2023

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O objetivo deste projeto foi determinar a atividade antimicrobiana de extratos do caule da Solanum lycocarpum St. Hill. A extração ocorreu pelo método de arraste com polaridades que variam do solvente apolar ao mais polar. Após a realização de uma fitoquímica qualitativa os testes antimicrobianos realizados foram a Concentração inibitória mínima e máxima, curva cinética de crescimento bacteriano, teste de disco-difusão e concentração bactericida mínima. Cada teste se relaciona e juntos podem determinar a o potencial antimicrobiano, se os fitoconstituintes de cada extrato e polaridade são bactericidas ou bacteriostáticos e afim eventos de resistência bacteriana. Os ensaios demonstraram que a dose mínima de extrato para todas as cepas fora de acima de 20 mg e a máxima entre 160 – 180 mg. Ainda os ensaios apresentaram eventos de resistência para as cepas Gram negativas (E. coli e P. aeruginosa). Portanto os bioativos de Lobeira apresentam atividade antimicrobiana, sendo ela bactericida e bacteriostática.

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“…Dentre as diversas espécies botânicas com potencial terapêutico, encontra-se a Byrsonima crassifolia (L.) Kunth, popularmente conhecida como "muricizeiro", cujas folhas e cascas da árvore são usadas na medicina popular para tratar tosses, dermatoses fúngicas, diarreia e mordida de cobra (BEJAR EZRA et al, 1995;MARTÍNEZ-VÁZQUEZ M. et al, 1999), além de apresentar um potencial antimicrobiano eficientes com extratos das raízes na inibição bacteriana (GELLEN & SILVA, 2016).…”

Section: Introductionunclassified