Atividade antioxidante e antimicrobiana de extratos de atemoia (Annona cherimola Mill. x A. squamosa L.)

Rabêlo, Suzana Vieira; Costa, Mateus Matiuzzi da; Libório, Rafael Cunha; Almeida, Jackson Roberto Guedes da Silva

doi:10.1590/s0100-29452014000500031

Cited by 26 publications

(23 citation statements)

References 19 publications

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“…This fact is justified by the more complex nature of the cell wall, due to the presence of a lipid barrier, which makes it difficult for many antimicrobial agents, including the plant extracts used in this work, to enter and act (GUIMARÃES et al, 2010). Due to the lack of this important barrier, gram-positive bacteria are more susceptible to the mechanisms of action displayed by the different JSP extracts (RABÊLO et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Jabuticaba skin extracts: phenolic compounds and antibacterial activity

Oliveira

Marques

Machado

et al. 2018

Braz. J. Food Technol.

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The phenolic compounds from various extracts of jabuticaba skin powder (JSP) were characterized in this study, and the antibacterial activity assessed. The phenolic compounds were extracted from the JSP using four methods: a) acetone extraction -1 g JSP: 10 mL 70% acetone, resting for 2 hours; b) aqueous extract -1 g JSP: 15 mL water, under agitation; c) ethanolic extract -1 g JSP: 15 mL acidified ethanol, under agitation; and d) methanolic extract -1 g JSP: 50 mL 50% methanol, under reflux. The antibacterial activity was evaluated by the agar diffusion assay, using Escherichia coli ATCC 11229, Salmonella choleraesuis ATCC 6539, Pseudomonas aeruginosa ATCC 15442, Staphylococcus aureus ATCC 6538 and Listeria monocytogenes ATCC 19117. The ethanolic and methanolic extracts showed the highest levels of phenolic compounds, especially of cyanidin chloride, catechin and epicatechin. The extracts did not inhibit the growth of Escherichia coli and Salmonella choleraesuis, but inhibited 30% of the growth of Pseudomonas aeruginosa with an extract concentration of 250 µg mL -1 . Against Staphylococcus aureus and Listeria monocytogenes the highest inhibitory effect observed was 41.8% for the ethanolic extract, followed by 36% inhibition by the methanolic extract, thus revealing the potential of these extracts as possible alternatives for use in the food and/or pharmaceutical industries. ResumoNeste estudo, caracterizaram-se os compostos fenólicos e avaliou-se a atividade antibacteriana de extratos obtidos da farinha da casca de jabuticaba (FCJ). Os compostos fenólicos da FCJ foram extraídos de quatro formas: a) extrato acetônico -1 g FCJ: 10 mL acetona 70%, duas horas em repouso; b) extrato aquoso -1 g FCJ: 15 mL água, sob agitação; c) extrato etanólico -1 g FCJ: 15 mL etanol acidificado, sob agitação; e d) extrato metanólico -1 g FCJ: 50 mL metanol 50%, sob refluxo. A atividade antibacteriana foi avaliada pela técnica de difusão cavidade em Ágar, utilizando-se os microrganismos Escherichia coli ATCC 11229, Salmonella cholerasuis ATCC 6539, Pseudomonas aeruginosa ATCC 15442, Staphylococcus aureus ATCC 6538 e Listeria monocytogenes ATCC 19117. Os extratos etanólico e metanólico apresentaram os teores mais elevados de compostos fenólicos, sobretudo o cloreto de cianidina, catequina e epicatequina. Os extratos não inibiram o crescimento de Escherichia coli e Salmonella choleraesuis, mas inibiu em 30% o crescimento de Pseudomonas aeruginosa na concentração do extrato de 250 µg mL -1 . A maior inibição de crescimento registrada foi de 41,8% pelo extrato etanólico, seguida pela inibição de 36% pelo extrato metanólico, contra as bactérias Staphylococcus aureus e Listeria monocytogenes, revelando assim a potencialidade destes extratos como possível alternativa para utilização na indústria de alimentos e/ou farmacêutica. Cite as: Jabuticaba skin extracts: phenolic compounds and antibacterial activity. Braz.

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Section: Resultsmentioning

confidence: 99%

Jabuticaba skin extracts: phenolic compounds and antibacterial activity

Oliveira

Marques

Machado

et al. 2018

Braz. J. Food Technol.

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“…Gram‐negative micro‐organisms are more resistant to antimicrobial action in relation to gram‐positive ones, as their cell wall is protected by a layer rich in polysaccharides, which makes the action of antibacterial substances present in the extracts difficult . Due to the greater susceptibility of gram‐positive micro‐organisms, it is believed that the mechanism of antimicrobial action of extracts is probably a consequence of their interaction with the peptidoglycan present in the bacterial cell wall, and which characterizes a more fragile barrier than the cell wall of gram‐negative bacteria . However, as observed in this study, the EEJS was effective in inhibiting the growth of both gram‐positive and gram‐negative bacteria, showing a great bactericide potential.…”

Section: Discussionmentioning

confidence: 61%

Antibacterial activity and in vivo wound healing potential of phenolic extracts from jaboticaba skin

et al. 2018

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In this study, different phenolic extracts were obtained from the jaboticaba skin meal (JSM), whose phenolic compounds were characterized and their antibacterial activities were assessed. Moreover, the activity of lyophilized ethanolic extract of jaboticaba skin (EEJS) on wound healing was analyzed in rats. The JSM phenolic extracts were obtained in four ways: aqueous, methanolic, ethanolic, and acetone extracts. The phenolic compounds were characterized in these extracts by high-performance liquid chromatography, and their antibacterial activities were evaluated. The in vivo experiment was divided into four groups and received the following treatments: G1-silver sulfadiazine (positive control); G2-EEJS at 10%; G3-EEJS at 5%, and G4-EEJS at 2.5%. The aqueous extract did not inhibit the growing of any bacterium. The ethanolic, acetone, and methanolic extracts inhibited the growing of all bacteria tested at the concentrations of 1.25%, 2.50%, and 5.00%, respectively. The ethanolic extract was the one that showed the highest bacterial inhibition potential and the highest contents of phenolic compounds, especially of catechin, epicatechin gallate, and epicatechin. The G3 and G4 treatments presented faster wound healing compared to the G1 one, as it promoted a less intense inflammatory reaction and full closure of the wounds at an accelerated rate.

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“…In addition, other metabolites found in the leaves and branches of A. subincanum, such as phenolics, might also contribute to some extent to the antimicrobial, as well as antioxidant activities. In fact, some authors have extensively correlated the antioxidant and antibacterial activities to the phenolic content of samples (Allahghadri et al, 2010;Rabêlo, Costa, Libório, & Almeida, 2014;Silva et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Biological activities of extracts from Aspidosperma subincanum Mart. and in silico prediction for inhibition of acetylcholinesterase

Rocha

Campana

Scoaris

et al. 2018

Phytotherapy Research

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Species of Aspidosperma are traditionally used to treat malaria, leishmaniasis, microbial, and inflammatory diseases. Aspidosperma subincanum Mart. known as "guatambu" is used in Brazilian traditional medicine to treat diabetes, hypercholesterolemia, and digestive diseases. Its tonic properties have been employed by the indigenous populations to stimulate the circulatory and genitourinary tracts and to improve respiratory function as well as to relieve spasms and to reduce fever. The species is known to contain antitumoural and antimalarial indole alkaloids. In the present study, various less explored biological activities of extracts from leaves and branches of A. subincanum were investigated, that is, inhibition of acetylcholinesterase as well as antioxidant and antibacterial activity. Twenty-one known indole alkaloids from this species were targeted for predicting the inhibition of acetylcholinesterase, and their biological activities were collected from the literature. Through in silico the prediction, the indole alkaloids uleine and derivatives demonstrated a strong probability of being able to inhibit the acetylcholinesterase enzyme, as well as the olivacine derivatives 3,4-dihydroolivacine and N-methyl-tetrahydro-olivacine (guatambuine), and the subincanadines C and E. Indeed, the extracts of A. subincanum showed acetylcholinesterase inhibitory activity, antioxidant activity in the lipid peroxidation assay, and antimicrobial activity against Staphylococcus aureus ATCC 25923, and their pharmacological properties should be explored further.

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Atividade antioxidante e antimicrobiana de extratos de atemoia (Annona cherimola Mill. x A. squamosa L.)

Cited by 26 publications

References 19 publications

Jabuticaba skin extracts: phenolic compounds and antibacterial activity

Jabuticaba skin extracts: phenolic compounds and antibacterial activity

Antibacterial activity and in vivo wound healing potential of phenolic extracts from jaboticaba skin

Biological activities of extracts from Aspidosperma subincanum Mart. and in silico prediction for inhibition of acetylcholinesterase

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