Atlas of Heart Anatomy and Development

Filipoiu, Florin Mihail

doi:10.1007/978-1-4471-5382-5

Cited by 12 publications

(7 citation statements)

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“…Certainly the orientation of this alignment matches that of the developing papillary muscles, and it is striking how the trabeculae form a root‐like network at the base of these muscles. In the adult human heart, trabeculae are believed to transmit the pressures exerted by the mitral ring and tendinous chordae from the papillary muscles, towards the heart's apex and ventricular wall (Axel, ; Filipoiu, ), and the manner in which the bases of papillary muscles associate with trabeculae in the mouse embryo heart suggests a likely similar role.…”

Section: Discussionmentioning

confidence: 99%

Morphogenesis of myocardial trabeculae in the mouse embryo

et al. 2016

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Formation of trabeculae in the embryonic heart and the remodelling that occurs prior to birth is a conspicuous, but poorly understood, feature of vertebrate cardiogenesis. Mutations disrupting trabecular development in the mouse are frequently embryonic lethal, testifying to the importance of the trabeculae, and aberrant trabecular structure is associated with several human cardiac pathologies. Here, trabecular architecture in the developing mouse embryo has been analysed using high‐resolution episcopic microscopy (HREM) and three‐dimensional (3D) modelling. This study shows that at all stages from mid‐gestation to birth, the ventricular trabeculae comprise a complex meshwork of myocardial strands. Such an arrangement defies conventional methods of measurement, and an approach based upon fractal algorithms has been used to provide an objective measure of trabecular complexity. The extent of trabeculation as it changes along the length of left and right ventricles has been quantified, and the changes that occur from formation of the four‐chambered heart until shortly before birth have been mapped. This approach not only measures qualitative features evident from visual inspection of 3D models, but also detects subtle, consistent and regionally localised differences that distinguish each ventricle and its developmental stage. Finally, the combination of HREM imaging and fractal analysis has been applied to analyse changes in embryonic heart structure in a genetic mouse model in which trabeculation is deranged. It is shown that myocardial deletion of the Notch pathway component Mib1 (Mib1 flox/flox; cTnT‐cre) results in a complex array of abnormalities affecting trabeculae and other parts of the heart.

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Section: Discussionmentioning

confidence: 99%

Morphogenesis of myocardial trabeculae in the mouse embryo

et al. 2016

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“…Heart development is a highly complex multistep process. Most comprehensive descriptions of human heart development are qualitative in nature and are summarised in textbooks ( Filipoiu, 2014 ; Oostra et al, 2007 ; Sadler, 2006 ; Schoenwolf et al, 2009 ). These textbooks make use of the many detailed qualitative studies on the emergence and appearance of structures (e.g.…”

Section: Introductionmentioning

confidence: 99%

Quantified growth of the human embryonic heart

et al. 2021

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The size and growth patterns of the components of the human embryonic heart have remained largely undefined. To provide these data, 3D heart models were generated from immunohistochemically stained sections of 10 human embryonic hearts ranging from Carnegie stage 10 till 23. Fifty-eight key structures were annotated and volumetrically assessed. Sizes of the septal foramina and atrioventricular canal opening were also measured. The heart grows exponentially throughout embryonic development. There was consistently less left than right atrial myocardium, and less right than left ventricular myocardium. We observed a later onset of trabeculation in the left atrium compared to the right. Morphometry showed that the rightward expansion of the atrioventricular canal starts in week 5. The septal foramina are less than 0.1 mm2 and are, therefore, much smaller than post-natal septal defects. This chronological, graphical atlas of the growth patterns of cardiac components in the human embryo provides quantified references for normal heart development. Thereby, this atlas may support early detection of cardiac malformations in the foetus.

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“…2 Triangle of Brocq and Mouchet is an arteriovenous triangle formed by AIA and CA of left coronary artery and great cardiac vein (GCV). 3 Topographic region of the triangle is located between conus aretriosus and left auricle. 4 The left coronary artery after its short course bifurcates into AIA and CA forming the apex of the triangle.…”

Section: Introductionmentioning

confidence: 99%

Anatomical Study of Triangle of Brocq and Mouchet in Human Cadaveric Heart

Kharbuja

Dhungel

2020

Nep. Med. Coll. J.

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Right and left coronary arteries maintain the nutritional supply of heart. The left coronary artery (LCA) bifurcates into Anterior Interventricular Artery (AIA) and Circumflex Artery (CA). Triangle of Brocq and Mouchet is an arterio-venous triangle formed by AIA and CA of left coronary artery and great cardiac vein (GCV) that lies between conus aretriosus and left auricle. This study aims to determine frequency of Brocq and Mouchet triangle and its anatomical details. This study was conducted in thirty formalin fixed cadaveric hearts collectively available in the Department of Anatomy, Nepal Medical College from November 2019 till April 2020. The incidence of heart showing the triangle was 93.3% with the most common type being closed which is followed by inferiorly opened, superiorly opened, and completely opened. Most frequent content of the triangle was median artery followed by diagonal branches of AIA and CA. the mean area of the triangle was 218.84mm2(527.97 mm2-57.26 mm2). The branches of LCA varied from bifurcation to pentafurcation. Relationship of GCV with AIA and CA was found to be either superficial or deep. The anatomical knowledge of the Brocq and Mouchet triangle regarding arterio-venous relationship will be required for angiographic procedures. Also, the triangle is a potential epicardial access route to mitral valve annulus thus detailed anatomical knowledge of the triangle will help cardiologist to achieve successful cardiological procedures with minimal complications.

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Atlas of Heart Anatomy and Development

Cited by 12 publications

References 0 publications

Morphogenesis of myocardial trabeculae in the mouse embryo

Morphogenesis of myocardial trabeculae in the mouse embryo

Quantified growth of the human embryonic heart

Anatomical Study of Triangle of Brocq and Mouchet in Human Cadaveric Heart

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