The elucidation of the nature of new phenomena requires a multi-pronged approach to understand the essential physics that underlies it. As an example, we study the simplified model containing a new scalar singlet accompanied by vector-like quarks, as motivated by the recent diphoton excess at the LHC. To be specific, we investigate three models with SU (2) L -doublet, vector-like quarks with Yukawa couplings to a new scalar singlet and which also couple off-diagonally to corresponding Standard Model fermions of the first or third generation through the usual Higgs boson. We demonstrate that three classes of searches can play important and complementary roles in constraining this model. In particular, we find that missing energy searches designed for superparticle production, supply superior sensitivity for vector-like quarks than the dedicated new quark searches themselves.
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