The launched MultiSpectral Instrument (MSI) equipped on Sentinel-2 satellites offers a powerful tool for observing the biogeochemical parameters of inland waters on a large scale. The proper use of atmospheric correction processors is essential for acquiring accurate satellite remote-sensing reflectance and downstream products. Therefore, we compared the performances of typical atmospheric correction processors, such as Sen2Cor, C2RCC-nets, C2RCC-C2X, Acolite, iCOR, Polymer, SeaDas/l2gen, and 6S processors, for MSI imagery over lake groups (N = 296) across China collected from 2016 to 2020. Linear fitting between corrected reflectance and in situ spectral measurements was used to assess performance; for the single lake, we additionally evaluated the performance of atmospheric correction processors in typical Chagan Lake in 2021. For largescale lake groups with different water quality backgrounds, the SeaDas/l2gen and C2RCC processors performed best for all band match-ups, and the C2RCC processor had the smallest errors. The SeaDas/l2gen processor works well for the signal bands (490, 560, 665, 704, and 740 nm), followed by the signal bands (560, 665, and 704 nm) of the C2RCC processor. For large-scale observations, this study revealed that Sentinel-2 satellite optical MSI imagery related to the C2RCC processor can be used to monitor aquatic systems with high-frequency investigations. For the signal band, the SeaDas/l2gen processor was used to select potential match-ups for the availability of MSI data related to the empirical models of processors. Our results may help satellite users select appropriate atmospheric correction processors for large-scale lake observations.