Atom engineering-regulated in situ transition of Cu(I)-Cu(II) for efficiently overcoming cancer drug resistance

Selenium-ruthenium complex blocks H1N1 influenza virus-induced cell damage by activating GPx1/TrxR1

“…Fluorescence content was measured using flow cytometry with at least 20 000 cells per independent sample. The cycle distribution of cell populations was analyzed as previously described 22 .…”

“…When the cell density reached 80%-90%, the cells in each group were treated with corresponding operations and cultured for 48 h. Lysis, denaturation, electrophoretic separation and western blotting of total intracellular proteins were performed as described in previous studies. The primary antibodies were incubated overnight, then the secondary antibody was incubated and the image were photographed by the Thermo Fisher Gel Imaging system 22 .…”

A multi-functional nano-platform based on LiGa4.99O8:Cr0.01/IrO2 with near infrared-persistent luminescence, “afterglow” photodynamic and photo-thermal functions

“…Over the past few years, nano-platforms based on transition metals have been thoroughly researched for the treatment of tumours. [13][14][15][16][17] Owing to their unique optical properties compared with conventional therapeutic treatments, transition metals are often used as photosensitizers for PDT and PTT. They play an important role in minimising adverse drug reactions and improving the effectiveness of cancer treatments.…”

Heteronuclear dual-metal atom catalysts for nanocatalytic tumor therapy

“…Thanks to the unique electronic structure that facilitates charge transfer and the unsaturated coordination environment of isolated single atoms, SACs not only possess extremely uniform microstructure and active site distribution, but also exhibit excellent catalytic activity and ideal selectivity [31][32][33][34][35][36]. The appeal advantage allows SACs to maximize the use of metal atoms and achieve satisfactory cancer treatment results at relatively low metal concentrations [37][38][39][40][41][42]. Importantly, the active sites are easy to accurately identify and characterize, which facilitates the further elucidating and understanding of the structure-performance relation and the catalytic mechanism, thus facilitating the oriented and rational design of more advanced SACs [43][44][45][46][47].…”