2022
DOI: 10.1002/prot.26396
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Atomistic insight into the luminal allosteric regulation of vesicular glutamate transporter 2 by chloride and protons: An all‐atom molecular dynamics simulation study

Abstract: Vesicular glutamate transporters (VGLUTs) are essential components of synaptic transmission in the brain. Synaptic vesicles' luminal chloride and low pH regulate VGLUTs allosterically in a cooperative way. The luminal allosteric regulation of VGLUTs by chloride (Cl−) and proton (H+) is possible through the collective work of luminal Cl− and H+ binding site residues. However, precise atomistic details about the luminal Cl− binding to the luminal Cl− binding site and the role of allosteric activation by H+ in VG… Show more

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Cited by 3 publications
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