Atomoxetine Improved Attention in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder and Dyslexia in a 16 Week, Acute, Randomized, Double-Blind Trial

Wietecha, Linda; Williams, David Wynne; Shaywitz, Sally E.; Shaywitz, Bennett A.; Hooper, Stephen R.; Wigal, Sharon B.; Dunn, David W.; McBurnett, Keith

doi:10.1089/cap.2013.0054

Cited by 46 publications

(52 citation statements)

References 31 publications

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“…An evaluation of this intervention did show a reduction in SCT symptoms among children diagnosed with ADHD-I 77 . The only study evaluating the effects of medication on SCT symptoms found atomoxetine to reduce SCT symptoms in youth with ADHD 78 , which aligns with other studies showing atomoxetine to be effective for youth with ADHD who have co-occurring internalizing problems (though findings are stronger for comorbid anxiety than for comorbid depression) 79–81 . The sole study evaluating SCT as a predictor of treatment response did not find SCT to impact response to methylphenidate 44 , although it should be acknowledged that this study used a limited measure of SCT and did not use a randomized design.…”

Section: Discussionsupporting

confidence: 74%

The Internal, External, and Diagnostic Validity of Sluggish Cognitive Tempo: A Meta-Analysis and Critical Review

Becker

Leopold

Burns

et al. 2016

Journal of the American Academy of Child & Adolescent Psych

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285

519

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Objective To conduct the first meta-analysis evaluating the internal and external validity of the sluggish cognitive tempo (SCT) construct as related to or distinct from attention-deficit/hyperactivity disorder (ADHD) and as associated with functional impairment and neuropsychological functioning. Method Electronic databases were searched through September 2015 for studies examining the factor structure and/or correlates of SCT in children or adults. The search procedures identified 73 papers. The core SCT behaviors included across studies, as well as factor loadings and reliability estimates, were reviewed to evaluate internal validity. Pooled correlation effect sizes using random effects models were used to evaluate SCT in relation to external validity domains (i.e., demographics, other psychopathologies, functional impairment, and neuropsychological functioning). Results Strong support was found for the internal validity of the SCT construct. Specifically, across factor analytic studies including over 19,000 individuals, 13 SCT items loaded consistently on an SCT factor as opposed to an ADHD factor. Findings also support the reliability (i.e., internal consistency, test-retest reliability, inter-rater reliability) of SCT. In terms of external validity, there is some indication that SCT may increase with age (r = 0.11) and be associated with lower socioeconomic status (r = 0.10). Modest (potentially negligible) support was found for SCT symptoms being higher in males than females in children (r = 0.05) but not adults. SCT is more strongly associated with ADHD inattention (r = 0.63 in children, r = 0.72 in adults) than with ADHD hyperactivity-impulsivity (r = 0.32 in children, r = 0.46 in adults), and it likewise appears that SCT is more strongly associated with internalizing symptoms than with externalizing symptoms. SCT is associated with significant global, social, and academic impairment (rs = 0.38–0.44). Effects for neuropsychological functioning are mixed, although there is initial support for SCT being associated with processing speed, sustained attention, and metacognitive deficits. Conclusion This meta-analytic review provides strong support for the internal validity of SCT and preliminary support for the external validity of SCT. In terms of diagnostic validity, there is not currently enough evidence to describe SCT in diagnostic terms. Key directions for future research are discussed, including evaluating the conceptualization of SCT as a transdiagnostic construct and the need for longitudinal research.

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Section: Discussionsupporting

confidence: 74%

The Internal, External, and Diagnostic Validity of Sluggish Cognitive Tempo: A Meta-Analysis and Critical Review

Becker

Leopold

Burns

et al. 2016

Journal of the American Academy of Child & Adolescent Psych

Self Cite

285

519

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“…The pediatric population also included patients with comorbid conditions of tics, depression, anxiety, oppositional defiant disorder (ODD), reading disorder, autism spectrum disorder, and dyslexia Bangs et al 2007;Geller et al 2007;Bangs et al 2008a;de Jong et al 2009;Dell'agnello et al 2009;Dittmann et al 2011;Harfterkamp et al 2012;Wietecha et al 2013). The adult population included patients with comorbid social anxiety and alcohol use disorders (Wilens et al 2008;Adler et al 2009a).…”

Section: Methodsmentioning

confidence: 99%

“…Each clinical trial included in the analysis had institutional review board (IRB) approval (study level and site level) and was conducted in accordance with the Declaration of Helsinki. All adult patients and a parent or guardian for each minor patient provided written informed consent to participate (Michelson et al 2001(Michelson et al , 2002Spencer et al 2002;Michelson et al 2003;Kelsey et al 2004;Allen et al 2005;Weiss et al 2005;Bangs et al 2007;Gau et al 2007;Geller et al 2007;Adler et al 2008;Bangs et al 2008a;Newcorn et al 2008;Wilens et al 2008;Adler et al 2009a,b;Block et al 2009;de Jong et al 2009;Dell'agnello et al 2009;Montoya et al 2009;Svanborg et al 2009;Takahashi et al 2009;Martenyi et al 2010;Dittmann et al 2011;Young et al 2011;Harfterkamp et al 2012;Hirata et al 2012;Wehmeier et al 2012;Durell et al 2013;Wietecha et al 2013).…”

Section: Methodsmentioning

confidence: 99%

“…The C-SSRS was utilized in one pediatric study (LYEB) conducted in the United States in patients with ADHD and comorbid dyslexia, and two adult trials (LYDZ and LYEE) conducted in the United States specifically in young adults or Asian adults with ADHD (Hirata et al 2012;Durell et al 2013;Wietecha et al 2013). The C-SSRS was designed to distinguish the domains of suicidal behavior and suicidal ideation by measuring the following four constructs: 1) Severity of ideation, 2) intensity of ideation, 3) behavior, and 4) lethality.…”

Section: Methodsmentioning

confidence: 99%

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Meta-Analysis of Suicide-Related Behavior or Ideation in Child, Adolescent, and Adult Patients Treated with Atomoxetine

Bangs

Wietecha²,

Wang³

et al. 2014

Journal of Child and Adolescent Psychopharmacology

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http://www.clinicaltrials.gov . The data reported are from an analysis of 23 pediatric and 9 adult clinical trials completed between 1998 and 2011. Ten pediatric (Studies HFBD, HFBK, LYAC, LYAS, LYAT, LYAW, LYAX, LYBG, LYBI, and LYBP) and two adult trials (Studies LYAA and LYAO) were conducted before the requirement to post trials at initiation (ongoing as of July 1, 2005) and, therefore, do not have a registration number. The registration numbers for the 13 pediatric trials meeting this requirement are: NCT00191698 (LYBX), NCT00486122 (LYCC), NCT00386581 (LYCZ), NCT00485459 (S010), NCT00191542 (LY15), NCT00191295 (LYBC), NCT00191906 (LYCK), NCT00192023 (LYCY), NCT00191945 (LYDM), NCT00546910 (LYDV), NCT00406354 (LYDW), NCT00380692 (S017), and NCT00607919 (LYEB). For the seven adult trials, the registration numbers are: NCT00190931 (LYBV), NCT00190957 (LYBY), NCT00190736 (LYCU), NCT00190775 (LYCW), NCT00190879 (LYDQ), NCT00510276 (LYDZ), and NCT00962104 (LYEE).

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“…Resultado semelhante foi encontrado na pesquisa realizada por Wietecha et al (2013), em que crianças com TDAH, com DD e com DD+TDAH tiveram seu desempenho em escalas de comportamento e em tarefa de memória operacional avaliadas antes e depois de serem submetidas a tratamento com atomoxetina, sendo verificada a melhora dos sintomas de TDAH nas crianças com DD+TDAH e com TDAH, mas não com as crianças só com DD, indicando que o medicamento atua de forma específica nas questões atencionais e comportamentais.…”

Section: Correlação Entre As Variáveis Pesquisadasunclassified

Caracterização de crianças com dislexia com e sem transtornos de déficit de atenção/hiperatividade

Alves¹

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AGRADECIMENTOSÀ Deus, pela vida abençoada que tenho. O Grande responsável por todas as conquistas até aqui.Aos meus amados pais Décio e Darci, meus pilares de sustentação, amores incondicionais da minha vida. Estejam certos de que a Educação proporcionada por vocês é o meu bem mais valioso.Aos meus queridos irmãos Stella, Décio Junior, Diego e amadas sobrinhas Giovanna, Maria Eduarda e Ana Laura. Vocês me completam e trazem mais alegria à minha vida.Ao meu orientador Prof. Dr. Erasmo Barbante Casella, pelo brilhantismo e profissionalismo em tudo o que faz. Agradeço por toda dedicação, orientação e conhecimento partilhado.À profa. Dra. Maria Silvia Cárnio, por sempre acreditar no meu potencial. Que eu possa seguir minha vida espelhando-me sempre em seus princípios de ética, profissionalismo e amor à Fonoaudiologia. Nenhuma palavra seria suficientemente boa para expressar meu carinho e minha eterna gratidão à você.À profa. Dra. Simone Aparecida Capellini, pela disponibilidade e valiosa contribuição em todos os momentos em que precisei.À minha querida cunhada Denise Laurindo Alves, minha irmã do coração, por todas as vezes que me socorreu não só com a impressora, com o computador, com o Excel, com a formatação, mas com a palavra de carinho, com o ombro amigo e pela certeza de que no final tudo daria certo.Ao fonoaudiólogo e amigo Aparecido José Couto Soares, pela parceria, pela compreensão nos momentos em que não pude contribuir tanto quanto eu gostaria de ter contribuído, por ter atendido tão prontamente cada solicitação de ajuda, por ouvir minhas queixas, por entender minhas angústias e me incentivar sempre.À minha sócia e amiga, psicóloga Júlia Mazon, que contribuiu imensamente sempre que necessário. Graças à você, pude me ausentar alguns períodos ciente que tudo estaria muito bem cuidado e administrado.

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Atomoxetine Improved Attention in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder and Dyslexia in a 16 Week, Acute, Randomized, Double-Blind Trial

Cited by 46 publications

References 31 publications

The Internal, External, and Diagnostic Validity of Sluggish Cognitive Tempo: A Meta-Analysis and Critical Review

The Internal, External, and Diagnostic Validity of Sluggish Cognitive Tempo: A Meta-Analysis and Critical Review

Meta-Analysis of Suicide-Related Behavior or Ideation in Child, Adolescent, and Adult Patients Treated with Atomoxetine

Caracterização de crianças com dislexia com e sem transtornos de déficit de atenção/hiperatividade

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