Atopic cataract: Changes in the lens epithelium and subcapsular cortex

Palmquist, B. M.; Philipson, Bo

doi:10.1007/bf02134255

Cited by 18 publications

(9 citation statements)

References 9 publications

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“…T h e focal epithelial degenerations has not previously been described in this or other types of cataract (Kobayashi & Suzuki 1975; Jensen & I a n -sen 1980; Fagerholm et al 1984). This seems to take place in an otherwise apparently healthy epithelium.…”

Section: Discussionmentioning

confidence: 57%

Cataract in retinitis pigmentosa An analysis of cataract surgery results and pathological lens changes

Philipson

1985

Acta Ophthalmologica

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The result of cataract surgery and lens pathoanatomical examination were presented in patients with retinitis pigmentosa (RP). A retrospective study of 24 cataract extractions in 15 RP patients was carried out, with special regard to visual outcome and surgical complications. The results were compared to an age matched randomly selected control group. In the retinitis pigmentosa group the post-operative visual acuity was generally good, and the surgical complications except for one case of central venous thrombosis were not more frequent than in the control group. Seven lenses from 5 patients with RP were analysed using transmission electron microscopy and quantitative microradiography. In the lenses with a progressive subcapsular edema, extensive extracellular vacuolization was found in the lens epithelium. Focal degeneration of epithelial cells was seen both in the more stationary posterior subcapsular cataracts and the progressive subcapsular cataracts. Different degrees of mitochondrial swelling was found in the epithelial cells of the stationary cataracts. The subcapsular lens fiber changes consisted of an extensive swelling of hydrated cells together with a significant reduction in their dry mass content. Migrating elongated nuclei-containing cells were found on the posterior capsule in both stationary and progressive cataracts.

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Section: Discussionmentioning

confidence: 57%

Cataract in retinitis pigmentosa An analysis of cataract surgery results and pathological lens changes

Philipson

1985

Acta Ophthalmologica

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“…Histological analysis of fibrous opacification has shown lens epithelial cell flattening and layering and ECM production [7] . The same histological findings are observed in the skin of atopic dermatitis patients and the airway mucosa of bronchial asthma patients.…”

Section: Discussionmentioning

confidence: 99%

“…Atopic cataract is occasionally complicated by fibrous opacification [6] . Histological analysis of fibrous opacification shows the production of extracellular matrix (ECM) and flattening and layering of lens epithelial cells [7] . Similarly, in bronchial asthma, fibrosis due to ECM production and cellular flattening and layering are seen in the basal membrane in the airway, and these changes are referred to as airway remodeling [8] .…”

Section: Introductionmentioning

confidence: 99%

Developmental Factors of Fibrous Opacification in the Atopic Cataract Lens Capsule

2010

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Aim: We investigated the developmental factors of fibrous opacification in the atopic cataract lens capsule. Method: We examined the expression of transforming growth factor (TGF)-β signals (phosphorylated Smad2/3 and Smad7) and plasminogen activator inhibitor (PAI)-1 in atopic cataract lenses by immunohistochemistry. The PAI-1 concentration in aqueous humor was also measured. Results: Lens epithelial cells of the atopic cataract lens capsule showed positive immunohistochemical staining for phosphorylated Smad2/3 and Smad7. Lens epithelial cells of the age-related cataract lens capsule were positive for phosphorylated Smad2/3, but negative for Smad7 by immunohistochemistry. All cells were negative for PAI-1. However, high concentrations of PAI-1 were detected in the aqueous humor of atopic cataract patients. Conclusion: We suggest that TGF-β and PAI-1 contribute to fibrous opacification in the atopic cataract lens capsule.

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“…Previously, it had been observed that Hrp60 is located in the mitochondrial membrane [65] and since a lens with atopic cataract had an increased amount of mitochondrias [66], it could be suggested that the increased energy produced by the mitochondria provoked an increased Hrp60 to protect the cells (Table 1). …”

Section: Heat Shock Proteins Involved In the Pathogenesis Of Oculamentioning

confidence: 99%

Heat Shock Proteins in the Human Eye

Urbak

Vorum

2010

International Journal of Proteomics

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Heat shock proteins (Hsps) are believed to primarily protect and maintain cell viability under stressful conditions such as those occurring during thermal and oxidative challenges chiefly by refolding and stabilizing proteins. Hsps are found throughout the various tissues of the eye where they are thought to confer protection from disease states such as cataract, glaucoma, and cancer. This minireview summarizes the placement, properties, and roles of Hsps in the eye and aims to provide a better comprehension of their function and involvement in ocular disease pathogenesis.

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Atopic cataract: Changes in the lens epithelium and subcapsular cortex

Cited by 18 publications

References 9 publications

Cataract in retinitis pigmentosa An analysis of cataract surgery results and pathological lens changes

Cataract in retinitis pigmentosa An analysis of cataract surgery results and pathological lens changes

Developmental Factors of Fibrous Opacification in the Atopic Cataract Lens Capsule

Heat Shock Proteins in the Human Eye

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