Atopic dermatitis

Weidinger, Stephan; Beck, Lisa A.; Bieber, Thomas; Kabashima, Kenji; Irvine, Alan D.

doi:10.1038/s41572-018-0001-z

Cited by 1,231 publications

(1,358 citation statements)

References 227 publications

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“…Though the prevalence of atopic dermatitis (AD) is highest in childhood, the chronic nature of the disease imposes a burden to the patient and society also in adulthood. Recent studies report a prevalence of 6–10%, in adults, which is higher than previously reported . Furthermore, a Danish study found persistent AD in 50% of an adult population diagnosed with AD in school age .…”

Section: Introductionmentioning

confidence: 71%

Atopic dermatitis is associated with increased use of social benefits: a register‐based cohort study

Slagor

Nørreslet

Ebbehøj

et al. 2019

Acad Dermatol Venereol

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Background The comprehensive consequences of atopic dermatitis (AD) include a negative influence on work life. However, data regarding use of social benefits in patients with AD are sparse. Objective To examine the association between AD and use of social benefits, with a specific focus on paid sick leave and disability pension. Methods The study cohort comprises citizens born in the period 1964–1999 with a diagnosis of AD registered in the Danish National Patient Registry (DNPR) and a 20‐fold match control group from the background population. Cross‐linkage of data from 1964 up to 2015 by four national registers (the DNPR; the Central Person Register; the Register of Medicinal Product Statistics; and the Danish Register for Evaluation of Marginalisation) enabled the comparison of AD patients and controls with respect to social benefits. Prescription of systemic medication served as a proxy for AD severity. Social benefits were analysed as a function of AD status using Cox regression. Results A total of 28 156 AD patients were registered in the DNPR, and the control group comprised 473 836 individuals not registered with AD in the DNPR. AD was found to be associated with increased risk of receiving social benefits, paid sick leave in particular, and most pronounced for younger patients with severe AD (OR = 1.37, 95% CI: 1.25–1.52). The use of disability pension was increased for all groups of AD patients compared to controls and most pronounced for older patients with severe AD [HR 1.67 (95% CI: 1.45–1.93)]. Conclusion Our data emphasize that AD significantly impacts work life negatively for the patients and is a financial burden for the society.

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Section: Introductionmentioning

confidence: 71%

Atopic dermatitis is associated with increased use of social benefits: a register‐based cohort study

Slagor

Nørreslet

Ebbehøj

et al. 2019

Acad Dermatol Venereol

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“…[1][2][3][4][5][6][7][8][9][10] The disease itself is not new, and descriptions can be found in ancient medical literature 11,12 with Emperor dermatologic descriptions in the 19th century, it became a clearcut entity in the 20th century, 11,12 especially when its prevalence started to increase in the last decades of the 20th century. [1][2][3][4][5][6][7][8][9][10] The disease itself is not new, and descriptions can be found in ancient medical literature 11,12 with Emperor dermatologic descriptions in the 19th century, it became a clearcut entity in the 20th century, 11,12 especially when its prevalence started to increase in the last decades of the 20th century.…”

Section: Introductionmentioning

confidence: 99%

Atopic eczema: burden of disease and individual suffering – results from a large EU study in adults

Ring

Zink

Arents

et al. 2019

Acad Dermatol Venereol

128

112

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Background Atopic eczema (AE, atopic dermatitis) is one of the most common non‐communicable inflammatory skin diseases affecting 1–5% of the adult population in Europe with marked impairment in quality of life. In spite of great progress in understanding the pathophysiology of disturbed skin barrier and immune deviation, AE still represents a problem in daily clinical practice. Furthermore, the true impact of AE on individual suffering is often not recognized. Objectives With a large European study, we wanted to provide insights into the actual suffering and individual burden of disease in adult patients with AE. Methods A total of 1189 adult patients (18–87 years, 56% female) with moderate to severe AE were recruited in nine European countries by dermatologists or allergists together with the help of patient organizations. A computer‐assisted telephone interview was performed by experienced interviewers between October 2017 and March 2018. The following instruments were used to assess severity or measure quality of life: Patient‐Oriented Eczema Measure (POEM), Dermatology Life Quality Index (DLQI), Hospital Anxiety and Depression Scale (HADS‐D) and a newly developed Atopic Eczema Score of Emotional Consequences (AESEC). Patients were also asked to self‐assess the severity of their disease. Results Despite current treatment, 45% of participants still had actual moderate to very severe AE in POEM. Due to their skin disease, 57% missed at least 1 day of work in the preceding year. DLQI showed moderate to extremely large impairment in 55%. According to HADS‐D, 10% scored on or above the threshold of eight points with signs of depressive symptoms. Assessed with AESEC, 57% were emotionally burdened with feelings such as ‘trying to hide the eczema’, ‘feeling guilty about eczema’, having ‘problems with intimacy’ and more. Of persons actually suffering from severe AE, 88% stated that their AE at least partly compromised their ability to face life. Conclusions This real‐life study shows that adults with a moderate to severe form of AE are suffering more than what would be deemed acceptable. There is a need for increased awareness of this problem among healthcare professionals, policymakers and the general public to support research in the development of new and more effective treatments and provide access to better and affordable health care for affected patients.

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“…Recent studies have demonstrated that dysbiosis of the skin microbiota and colonization by Staphylococcus aureus are common in AD . However, the exact mechanism of skin microbiota involvement in AD patients is not clear.…”

Section: Importance Of Exosomes In Chronic Inflammatory Skin Diseasesmentioning

confidence: 99%

Exosomes in chronic inflammatory skin diseases and skin tumors

Wang

Jin

2019

Experimental Dermatology

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Exosomes are membrane vesicles of endocytic origin that can mediate communication between cells and the transport of cellular components such as microRNAs, mRNAs, proteins and DNA. Recently, exosomes have been under investigation for their significant roles in both healthy physiology and disease states. Herein, we review the role of exosomes in chronic inflammatory skin diseases and skin tumors, especially focusing on systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous pemphigoid and melanoma. Moreover, we emphasize the involvement of changes in exosome cargo in the regulation of these diseases.

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Atopic dermatitis

Cited by 1,231 publications

References 227 publications

Atopic dermatitis is associated with increased use of social benefits: a register‐based cohort study

Atopic dermatitis is associated with increased use of social benefits: a register‐based cohort study

Atopic eczema: burden of disease and individual suffering – results from a large EU study in adults

Exosomes in chronic inflammatory skin diseases and skin tumors

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