Atopic Dermatitis

Wolter, Sierra; Price, Harper

doi:10.1016/j.pcl.2013.11.002

Cited by 43 publications

(30 citation statements)

References 56 publications

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“…Роль Т-хелперов 2-го типа (Тh 2 ) и продуцируе-мых ими цитокинов -интерлейкинов (ИЛ-4, 5, 13) -изучена достаточно детально [14]. Однако в послед-ние 5 лет получены данные, позволяющие пересмо-треть концепцию Тh 2 -опосредованного генеза ал-лергического ответа.…”

Section: механизмы контроля целостности барьеров организма млекопитающихunclassified

The role of infection in the pathogenesis of allergodermatoses

Svirshchevskaya¹,

Matushevskaya²,

Chudakov³

et al. 2015

Klin. dermatol. venerol.

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В обзоре представлены данные зарубежных и отечественных клинических исследований по изучению роли инфекции в патогенезе аллергодерматозов и влиянию микробной флоры на течение атопического дерматита (АтД). Даны общие сведения по микрофлоре кожи: нормальная, условно-патогенная и патогенная. Показано, что микробная флора кожи у значительной части больных аллергодерматозами вызывает осложнения в течении основного заболевания. Представлены механизмы контроля целостности барьеров организма млекопитающих, в частности, отмечена роль эпидермального барьера при ассоциации АтД и инфекции. Выделены основные направления в лечении аллергодерматозов, основанные на международных и российских клинических рекомендациях по лечению АтД. Определено место топических антибактериальных и комбинированных препаратов в терапии осложненных форм аллергодерматозов. Ключевые слова: аллергодерматозы, атопический дерматит, стафилококк, лимфоидные клетки врожденного иммунитета 2-го типа, топическая терапия, комбинированная терапия, Акридерм.The review presents the data of foreign and national clinical studies on the role of infection in the pathogenesis of allergodermatoses and the influence of the microbial flora on the course of atopic dermatitis. General information on the normal, opportunistic and pathogenic microflora of the skin is provided. It is shown that the microbial flora of the skin causes complications of an underlying disease in a significant proportion of patients with allergodermatoses. The control mechanisms of the integrity of the body's barriers in mammals are presented. In particular, the role of the epidermal barrier impairment on the association of atopic dermatitis and infection is discussed. The main directions in the treatment of allergodermatoses are described based on Russian and International Clinical Guidelines for the treatment of atopic dermatisis. The significance of topical antibacterial and combined drugs in the treatment of complicated allergodermatoses is defined.

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Section: механизмы контроля целостности барьеров организма млекопитающихunclassified

The role of infection in the pathogenesis of allergodermatoses

Svirshchevskaya¹,

Matushevskaya²,

Chudakov³

et al. 2015

Klin. dermatol. venerol.

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“…диатрии [6][7][8][9][10]. Данные статистических отчетов не отражают истинной распространенности аллерги-ческих заболеваний, так как учитывают в основном тяжелые формы заболевания, требующие обраще-ния к врачу.…”

Section: Abstract: Atopic Dermatitis Children Prevalenceunclassified

A study of the prevalence of atopic dermatitis symptoms in school-aged children of Zhalal-Abad

Muratova¹

2015

Klin. dermatol. venerol.

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Среди аллергических заболеваний кожи у детей атопический дерматит (АтД) занимает одно из веду-щих мест. Распространенность этого заболевания, по данным эпидемиологических исследований [1][2][3][4][5], колеблется в широких пределах. АтД из-за своей высокой распространенности у детей, раннего нача-ла и быстрого формирования хронических форм представляет собой одну из актуальных проблем пе- Atopic dermatitis (AtD) is one of the topical challenges of pediatrics due to its high prevalence, an early onset, and fast development of chronic forms. The aim of the study was to obtain data on the prevalence of the AtD symptoms in children of the school age in the city of Zhalal-Abad. Material and methods. The study was conducted by questionnaire survey (ISAAC program) among 8 th -grade schoolchildren and among parents of the first-graders in 23 schools of Zhalal-Abad. 4235 schoolchildren of different ethnic groups aged 7-8 and 13-14 years were surveyed. Results and discussion. The trial results, which were verified and accepted by the ISAAC International Center (Oakland, New Zealand), revealed rather high incidence of the AtD symptoms in schoolchildren of Zhalal-Abad. The presence of this disease was detected in 5.25% of children. Among 4235 schoolchildren aged 7-8 and 13-14 years, AtD was found in 2.7 and 7.8% children, respectively. A comparison the obtained results for the AtD prevalence with that in other regions of the Kyrgyz Republic and the Russian Federation revealed that the AtD prevalence was actually the same as in Bishkek, but higher than in Cheboksary. AtD occurs 2.8 times more frequently in the 8 th -graders than in the first-graders. The gender differences in the prevalence of AtD in the group of children aged 7-8 years were statistically insignificant. Conclusions. The regional versions of the standardized questionnaire of the «International Study of Asthma and Allergies in Childhood» program in the Kyrgyz and Uzbek languages may be used for detecting the AtD symptoms in children at cohort and individual levels.

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“…A given concentration of a topical steroid is more potent in an ointment than in a cream. The classification of topical corticosteroids based on potency is shown in Table 3 [51,52].…”

Section: Topical Steroidsmentioning

confidence: 99%

Atopic Dermatitis: Insights on Pathogenesis, Evaluation and Management

S¹

2014

J Allergy Ther

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Background: Atopic Dermatitis (AD) is a highly pruritic chronic inflammatory skin disease that commonly presents during early childhood. Several studies indicate that the disease is very common in western world with lifetime prevalence in children of 10% to 20%. Data sources:We make recommendations regarding the evaluation and management of AD in children based on systematic literature searches using the best-available evidence from PubMed, Medline, Google Scholar, NICE, the American Academy of Dermatology and the World Allergy Organization.Results: AD has an immunologic basis. Both innate and adaptive immune responses are impaired in AD patients. Intense pruritus is a hallmark of the disease which leads to extensive scratching and further breakdown of the skin barrier. Treatment of AD may be topical or systemic. Topical corticosteroids and calcineurin inhibitors are used as topical anti-inflammatory agents. Patients should be carefully instructed in the use of topical glucocorticoids to avoid side effects. Conclusions:Treatment of atopic eczema should be based on a "stepped-care plan" where treatments are stepped up or down depending on the assessment of the state of the child's skin by the physician. Physicians who treat children with mild to moderate AD should tell children and their caregivers that AD is a lifelong illness.

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Atopic Dermatitis

Cited by 43 publications

References 56 publications

The role of infection in the pathogenesis of allergodermatoses

The role of infection in the pathogenesis of allergodermatoses

A study of the prevalence of atopic dermatitis symptoms in school-aged children of Zhalal-Abad

Atopic Dermatitis: Insights on Pathogenesis, Evaluation and Management

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