Atopic Dermatitis Across Shades of Skin

Clinical features of atopic dermatitis in pediatric patients with skin of color and comparison with different phototypes

“…Nummular eczema had an overall low prevalence (13%), in line with other literature data, reporting a prevalence of 15%–17% in AD and the occurrence of eczematous lesions typically on extensor surfaces and on the trunk. 4 Nummular eczema, prurigo nodularis, and intense xerosis, were observed mainly in SOC patients (respectively 21%, 32%, and 40%) ( p < 0.001). As suggested by Muizzuddin et al., SOC is more likely to develop an intense level of xerosis, as a result of higher protein cohesion and lower ceramide levels in the upper layers of the stratum corneum.…”

“…Recently, the need to gain a deeper understanding of AD clinical features in the skin of color (SOC), is emerging, as AD features in SOC are too often underreported and pathologized, addressing clinical findings as "atypical." 4 In this study, we aimed to give AD a wider characterization among different shades of skin, by characterizing clinical signs of AD in SOC patients and by comparing these signs with those of non-SOC patients.…”

“…Recently, the need to gain a deeper understanding of AD clinical features in the skin of color (SOC), is emerging, as AD features in SOC are too often underreported and pathologized, addressing clinical findings as "atypical." 4 In this study, we aimed to give AD a wider characterization among different shades of skin, by characterizing clinical signs of AD in SOC patients and by comparing these signs with those of non-SOC patients.We conducted a retrospective study on all the consecutive AD patients attending the Dermatology Unit of the Pediatric Hospital IRCCS Giannina Gaslini in Genoa, from September to December 2023. All patients were visited for the first time.…”

“…However, AD may have very different clinical features, and wide clinical heterogeneity exists across different skin types. Recently, the need to gain a deeper understanding of AD clinical features in the skin of color (SOC), is emerging, as AD features in SOC are too often underreported and pathologized, addressing clinical findings as “atypical.” 4 …”

“…In line with the literature, the “typical” flexural eczema was more frequently observed in non‐SOC patients ( p = 0.006263). 4 This may be attributed to the difficulty of detecting erythema in SOC. Indeed, SOC skin inflammation appears as violaceous or darker brown, resulting in a lower color contrast with background skin compared to non‐SOC patients.…”