Lichen amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. We report the case of a 66-year-old woman who presented to clinic with intense pruritus of the shins for 40 years. This patient showed a complete response to the Janus kinase (JAK) inhibitor upadacitinib and we therefore suggest JAK inhibition as a targeted treatment strategy for LA.
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