Atopic Dermatitis: an Update and Review of the Literature

Lipozenčić, Jasna; Wolf, Ronni

doi:10.1016/j.det.2007.06.009

Cited by 48 publications

(34 citation statements)

References 35 publications

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“…Atopy is understood to be an imbalance between the Th2 and Th1 type immune responses, with the cutaneous inflammatory response in eczema being at least partly mediated by Th2 cytokines [1,13,14]. Our data showed all patients affected by eczema present serum levels of IL-4, IL-5, IL-2, IL-10 higher than normal controls, confirming that Th2 cells play an important role in the pathogenesis of this form.…”

Section: Discussionsupporting

confidence: 73%

Cytokines Levels in Children Affected by Atopic and Nonatopic Eczema

Ricci¹,

Patrizi²,

Bellini³

et al. 2008

TODJ

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Abstract:Patients with atopic eczema present higher serum levels of total IgE and different pattern of cytokines, compared to nonatopic eczematous patients. This study aimed to evaluate serum levels of IL-2, IL-4, IL-5, IL-10, IFN , TNF in eczematous children in relation to atopic and nonatopic form. We enrolled 45 eczematous children and 12 controls. Total IgE and specific IgE against principal food and inhalant allergens were evaluated by UniCap1000 and levels of cytokines by Cytometric Bead Array System. The geometric means of levels of IL-4 were higher in eczematous patients than controls (P=0.036). Serum levels of IL-10 and IFN were higher in nonatopic eczematous children than in atopic eczematous patients and controls (P= 0.004, P= 0.003). Our data confirm that cytokines may play an important role in the pathogenesis of eczema: nonatopic eczema seems to be characterized by increased levels of IL-10 and IFN compared to atopic form.

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Section: Discussionsupporting

confidence: 73%

Cytokines Levels in Children Affected by Atopic and Nonatopic Eczema

Ricci¹,

Patrizi²,

Bellini³

et al. 2008

TODJ

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“…The water content of the SC is important for the appearance and physiological function of the skin. Reduced hydration in the SC has been found in many skin diseases, such as atopic dermatitis, eczema, and psoriasis [12,13], and is considered to induce itching and scratching [14]. Itchinduced scratching worsens skin conditions and newly provokes and sustains skin inflammation, which in turn leads to continued intense itching sensations.…”

Section: Introductionmentioning

confidence: 99%

Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear

Yeom

Kim

Lee

et al. 2012

Journal of Dermatological Science

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“…Atopic dermatitis is a chronic, inflammatory skin condition that affects 10% to 20% of children and 1% to 3% of adults in the US (Lipozencic and Wolf 2007). Symptoms include erythema, scaling and pruritus in affected areas, and often result in sleeplessness, psychological stress, poor self-esteem, anxiety, and poor school or work preformance.…”

Section: Introductionmentioning

confidence: 99%

New and emerging trends in the treatment of atopic dermatitis

Gelbard

Hebert

2009

PPA

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Atopic dermatitis is a chronic, inflammatory skin condition that affects 10% to 20% of children and 1% to 3% of adults in the US. Symptoms often result in sleeplessness, psychological stress, poor self-esteem, anxiety, and poor school or work performance. The cost of atopic dermatitis is estimated to be US$0.9 to 3.8 billion every year. Topical steroids are first-line treatment for atopic dermatitis, and recent advances in vehicle technologies have resulted in improved patient tolerability and compliance. Topical calcineurin inhibitors are also safe and effective topical treatments for atopic dermatitis, and provide an additional therapeutic option for patients with this disease. Systemic immunomodulators are used in the treatment of severe refractory disease. Cyclosporine, methotrexate, azathioprine, mycophenolate mofetil, and interferon gamma have been used in the management of severe atopic dermatitis. This review highlights the current and emerging trends in the treatment of atopic dermatitis.

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Atopic Dermatitis: an Update and Review of the Literature

Cited by 48 publications

References 35 publications

Cytokines Levels in Children Affected by Atopic and Nonatopic Eczema

Cytokines Levels in Children Affected by Atopic and Nonatopic Eczema

Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear

New and emerging trends in the treatment of atopic dermatitis

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