Atopic dermatitis

Abramovits, William

doi:10.1016/j.jaad.2005.04.034

Cited by 165 publications

(126 citation statements)

References 66 publications

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“…Indeed, recent findings point to pDC as important contributors to chronic immune-based disorders such as lupus erythematosus and psoriasis (40 -43). Similarly, macrophages are emerging as malleable immune regulatory cells, associated with chronic inflammatory conditions, including atopic dermatitis (44). Thus the cells recruited by active chemerin are capable of complex regulation of immune responses.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus-Derived Staphopain B, a Potent Cysteine Protease Activator of Plasma Chemerin

Kulig¹,

Zabel

Dubin

et al. 2007

The Journal of Immunology

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Chemerin is an attractant for cells that express the serpentine receptor CMKLR1, which include immature plasmacytoid dendritic cells (pDC) and macrophages. Chemerin circulates in the blood where it exhibits low biological activity, but upon proteolytic cleavage of its C terminus, it is converted to a potent chemoattractant. Enzymes that contribute to this conversion include host serine proteases of the coagulation, fibrinolytic, and inflammatory cascades, and it has been postulated that recruitment of pDC and macrophages by chemerin may serve to balance local tissue immune and inflammatory responses. In this work, we describe a potent, pathogen-derived proteolytic activity capable of chemerin activation. This activity is mediated by staphopain B (SspB), a cysteine protease secreted by Staphylococcus aureus. Chemerin activation is triggered by growth medium of clinical isolates of SspB-positive S. aureus, but not by that of a SspBnull mutant. C-terminal processing by SspB generates a chemerin isoform identical with the active endogenous attractant isolated from human ascites fluid. Interestingly, SspB is a potent trigger of chemerin even in the presence of plasma inhibitors. SspB may help direct the recruitment of specialized host cells, including immunoregulatory pDC and/or macrophages, contributing to the ability of S. aureus to elicit and maintain a chronic inflammatory state.

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Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus-Derived Staphopain B, a Potent Cysteine Protease Activator of Plasma Chemerin

Kulig¹,

Zabel

Dubin

et al. 2007

The Journal of Immunology

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“…To identify TSLP-inducing cytokines, we used a cytokine combination that mimics the atopic microenvironment. This included TNF-␣, together with the Th2 cytokines IL-4, IL-5, and IL-13 (15,16). In cultured primary normal human skin keratinocytes, we detected baseline levels of TSLP mRNA (Ref.…”

Section: Proinflammatory and Th2 Cytokines Synergize To Induce Tslp Pmentioning

confidence: 99%

Cutting Edge: Proinflammatory and Th2 Cytokines Synergize to Induce Thymic Stromal Lymphopoietin Production by Human Skin Keratinocytes

Bogiatzi

Fernandez

Bichet

et al. 2007

The Journal of Immunology

245

203

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Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that strongly activates dendritic cells (DC) and can initiate allergic inflammation. The factors inducing the production of human TSLP are not known. In this study, we show that proinflammatory (TNF-α or IL-1α) and Th2 (IL-4 or IL-13) cytokines synergized to induce the production of TSLP in human skin explants. TSLP production in situ was restricted to epidermal keratinocytes of the suprabasal layer. TSLP production could not be inhibited by factors regulating Th2 inflammation, such as IL-10, TGF-β, or IFN-γ. Cytokine-treated skin culture supernatants induced the maturation of blood CD11c+ DC in a TSLP-dependent manner. Our data provide the first evidence of TSLP induction and subsequent DC activation in human skin. Blocking TSLP-inducing cytokines could represent a novel strategy for the treatment of allergic diseases.

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“…8,9) But, the pathogens of AD are not completely understood, although several cell types (e.g., T lymphocytes, Langerhans cells, eosinophils, keratinocytes) and factors (e.g., cytokines and immunoglobulins, particularly IgE) have been implicated. 10) It has been accepted that topical steroid therapy is crucial for the management of the disease, but it cannot be used for long periods and side effects were frequently observed. Results from several studies indicate that AD patients may benefit from herbal therapy in Oriental medicine.…”

mentioning

confidence: 99%

Inhibitory Effects of Saururus chinensis (LOUR.) BAILL on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

Choi

Kim

Lee

et al. 2008

Biological & Pharmaceutical Bulletin

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Atopic dermatitis

Cited by 165 publications

References 66 publications

Staphylococcus aureus-Derived Staphopain B, a Potent Cysteine Protease Activator of Plasma Chemerin

Staphylococcus aureus-Derived Staphopain B, a Potent Cysteine Protease Activator of Plasma Chemerin

Cutting Edge: Proinflammatory and Th2 Cytokines Synergize to Induce Thymic Stromal Lymphopoietin Production by Human Skin Keratinocytes

Inhibitory Effects of Saururus chinensis (LOUR.) BAILL on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

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