Inhibitory Effects of Saururus chinensis (LOUR.) BAILL on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

Choi, Minho; Kim, Eui Chul; Lee, Hyung Suk; Kim, Sun Kwang; Choi, Hyun Myung; Park, Jung Hyuk; Han, Jae-Bok; An, Hyo Jin; Um, Jae Young; Kim, Hyung Min; Han, Ah‐Reum; Hong, Moo Chang; Bae, Hyunsu; Min, Byung-Il

doi:10.1248/bpb.31.51

Cited by 26 publications

(19 citation statements)

References 37 publications

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“…10) Studies have shown that S. chinensis has various activities, including anti-inflammatory, anti-oxidant, 11,12) antiangiogenic, 13) anti-asthmatic, 14) and anti-hypertensive 15) activities, as well as therapeutic activity against atopic dermatitis. 16) Among the bioactive compounds isolated from S. chinensis, manassantin A is a major phytochemical composition that has various biological activities, including anti-inflammatory, neuroleptic, and human acyl-CoA : cholesterol acyltransferase (ACA T) inhibitory activities. 17) Multiple reports have also described manassantin A as having various beneficial effects, including the abilities to reduce hyperpigmentation disorders, prevent atherosclerosis, and lower cholesterol.…”

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confidence: 99%

Protective Effects of Manassantin A against Ethanol-Induced Gastric Injury in Rats

Song

Seo

Kim

et al. 2016

Biological & Pharmaceutical Bulletin

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Manassantin A, a neolignan isolated from Saururus chinensis, is a major phytochemical compound that has various biological activities, including anti-inflammatory, neuroleptic, and human acyl-CoA : cholesterol acyltransferase (ACAT) inhibitory activities. In this study, we investigated the protective effects of manassantin A against ethanol-induced acute gastric injury in rats. Gastric injury was induced by intragastric administration of 5 mL/kg body weight of absolute ethanol to each rat. The positive control group and the manassantin A group were given oral doses of omeprazole (20 mg/kg) or manassantin A (15 mg/kg), respectively, 1 h prior to the administration of absolute ethanol. Our examinations revealed that manassantin A pretreatment reduced ethanol-induced hemorrhage, hyperemia, and epithelial cell loss in the gastric mucosa. Manassantin A pretreatment also attenuated the increased lipid peroxidation associated with ethanolinduced acute gastric lesions, increased the mucosal glutathione (GSH) content, and enhanced the activities of antioxidant enzymes. The levels of pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-1β were clearly decreased in the manassantin A-pretreated group. In addition, manassantin A pretreatment enhanced the levels of cyclooxygenase (COX)-1, COX-2, and prostaglandin E 2 (PGE 2 ) and reduced the inducible nitric oxide synthase (iNOS) overproduction and nuclear factor kappa B (NF-κB) phosphorylation. Collectively, these results indicate that manassantin A protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/ PGE 2 stimulation, inhibition of iNOS production and NF-κB activation, and improvements in the antioxidant and anti-inflammatory status.

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confidence: 99%

Protective Effects of Manassantin A against Ethanol-Induced Gastric Injury in Rats

Song

Seo

Kim

et al. 2016

Biological & Pharmaceutical Bulletin

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“…baill (SC), viscum album L. (VA), and houttuynia cordat are main active compounds in TMC. SC is the herb that used for treating various skin diseases including atopic dermatitis (Choi et al, 2008) and it has been reported that SC could possesses a number of biological effects, such as anti-allergic and antiinflammatory (Scalbert et al, 2000;Parr et al, 2000). VA has been reputed against hypertension, arthritis, and immune system stimulation (Orhan et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of Taemyeongcheong on allergic reactions

Ryu¹,

Yoou²,

Park³

2016

TANG [HUMANITAS MEDICINE]

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Taemyeongcheong (TMC) is Korean traditional extracted drink with various health ingredients. TMC has been used to treat hepatic damage, obesity, gastritis, and colitis. However, the role of TMC on allergic reaction has not been studied yet. In this study, we investigated the anti-allergic effects of TMC against a compound 48/80-induced systemic anaphylactic reaction and IgE-mediated passive cutaneous anaphylaxis (PCA). TMC significantly inhibited the compound 48/80-induced systemic anaphylactic reaction and IgE-mediated PCA reaction. Furthermore, TMC reduced the levels of interleukin (IL)-1β, IL-4, IL-13, and vascular endothelial growth factor in the serum of mice under PCA reaction. Taken together, these results suggest that TMC can play a useful role as an anti-allergic agent.

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“…Saururus is a perennial herbaceous plant used in Korean folk medicine for the treatment of various conditions such as edema, jaundice, gonorrhea and used has been employed as an antipyretic, diuretic, and anti-inflammatory agent (Choi et al, 2008). It has been shown to have anti-oxidant activity (Y. S. Lee et al, 2004) and has been used in the management of various skin diseases including AD in Eastern countries.…”

Section: Saururus Chinensis Baillmentioning

confidence: 99%

Natural Products and Dermatological Hypersensitivity Diseases

MacDonald¹,

Kulka²

2012

Allergic Diseases - Highlights in the Clinic, Mechanisms and Treatment

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Inhibitory Effects of Saururus chinensis (LOUR.) BAILL on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

Abstract: The present study was performed to examine whether the leaves of Saururus chinensis (LOUR. )

Cited by 26 publications

References 37 publications

Protective Effects of Manassantin A against Ethanol-Induced Gastric Injury in Rats

Protective Effects of Manassantin A against Ethanol-Induced Gastric Injury in Rats

Inhibitory effect of Taemyeongcheong on allergic reactions

Natural Products and Dermatological Hypersensitivity Diseases

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